scholarly journals Morphine in the Setting of Acute Heart Failure: Do the Risks Outweigh the Benefits?

2020 ◽  
Vol 6 ◽  
Author(s):  
Oren Caspi ◽  
Doron Aronson
Keyword(s):  
Heart Failure ◽  
Adverse Event ◽  
Acute Heart Failure ◽  
Observational Studies ◽  
Retrospective Studies ◽  
Acute Pulmonary Oedema ◽  
Physiological Effects ◽  
Future Perspectives ◽  
Safety And Efficacy ◽  
Clinical Benefits

The use of opioids in acute pulmonary oedema is considered standard therapy by many physicians. The immediate relieving effect of morphine on the key symptomatic discomfort associated with acute heart failure, dyspnoea, facilitated the categorisation of morphine as a beneficial treatment in this setting. During the last decade, several retrospective studies raised concerns regarding the safety and efficacy of morphine in the setting of acute heart failure. In this article, the physiological effects of morphine on the cardiovascular and respiratory systems are summarised, as well as the potential clinical benefits and risks associated with morphine therapy. Finally, the reported clinical outcomes and adverse event profiles from recent observational studies are discussed, as well as future perspectives and potential alternatives to morphine in the setting of acute heart failure.

In-hospital management of acute heart failure: Practical recommendations and future perspectives

2015 ◽  
Vol 201 ◽  
pp. 231-236 ◽  
Author(s):  
Dimitrios Farmakis ◽  
John Parissis ◽  
Apostolos Karavidas ◽  
Charalambos Karvounis ◽  
Filippos Triposkiadis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Hospital Management ◽  
Future Perspectives ◽  
Practical Recommendations

Clinical benefits of empagliflozin in very old patients with type 2 diabetes hospitalized for acute heart failure

2021 ◽  
Author(s):  
Luis M. Pérez‐Belmonte ◽  
Jaime Sanz‐Cánovas ◽  
Mercedes Millán‐Gómez ◽  
Julio Osuna‐Sánchez ◽  
Almudena López‐Sampalo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 2 Diabetes ◽  
Acute Heart Failure ◽  
Old Patients ◽  
Very Old ◽  
Clinical Benefits ◽  
Very Old Patients

scholarly journals Safety and efficacy of off-label use of ivabradine in patients with acute heart failure

2019 ◽  
Vol 31 (4) ◽  
pp. 179-187 ◽  
Author(s):  
Khaled M. Said Othman ◽  
Mohamed Ahmed Radwan Mostafa ◽  
Ahmed Elsayed Yosef ◽  
Adham Ahmed Abdeltawab
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Off Label Use ◽  
Safety And Efficacy ◽  
Off Label ◽  
Label Use

scholarly journals Nitrates for the Management of Acute Heart Failure Syndromes, A Systematic Review

2016 ◽  
Vol 22 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Mohamed Farag ◽  
Ahmad Shoaib ◽  
Diana A. Gorog
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Beneficial Effect ◽  
Acute Heart Failure ◽  
Heart Failure Therapy ◽  
Safety And Efficacy ◽  
Alternative Interventions ◽  
Acute Heart Failure Syndromes ◽  
Modern Era ◽  
Robust Evidence

Intravenous nitrates are widely used in the management of acute heart failure syndrome (AHFS) yet with lack of robust evidence to support their use. We therefore sought to analyze all randomized studies that evaluated the effects of nitrates on clinical outcomes in patients with AHFS. In total, 15 relevant trials comparing nitrates and alternative interventions in 1824 patients were identified. All but 3 were conducted before 1998. No trials demonstrated a beneficial effect on mortality, apart from 1 trial reporting a reduction in mortality, which was related to the time of treatment. Retrospective review suggests that there is a lack of data to draw any firm conclusions concerning the use of nitrates in patients with AHFS. More studies are needed to evaluate the safety and efficacy of these agents in the modern era of guideline-directed use of heart failure therapy.

scholarly journals Ultrafiltration in Acute Heart Failure

2019 ◽  
Vol 5 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Maria Rosa Costanzo
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Serum Creatinine ◽  
Acute Heart Failure ◽  
Fluid Overload ◽  
Vital Signs ◽  
Venous Access ◽  
Safety And Efficacy ◽  
Fluid Removal ◽  
Poor Outcomes

Congestion is the predominant cause of more than 1 million annual heart failure hospitalisations and recurrent fluid overload predicts poor outcomes. Unresolved congestion trumps serum creatinine increases in predicting adverse heart failure outcomes. No pharmacological approach for acute heart failure has reduced these deleterious consequences. Simplified ultrafiltration devices permit fluid removal in lower acuity hospital settings, but results regarding safety and efficacy have been variable. However, adjustment of ultrafiltration rates to patients’ vital signs and renal function has been associated with more effective decongestion and fewer heart failure events. Many aspects of ultrafiltration, including patient selection, fluid removal rates, venous access, prevention of therapy- related complications and costs, require further investigation.

620 Modifications of left atrial reservoir function early after acute heart failure

1999 ◽  
Vol 1 ◽  
pp. S103-S103
Author(s):  
M ALIMENTO ◽  
P BARBIER ◽  
A GRIMALDI ◽  
G BERNA ◽  
M GUAZZI
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Left Atrial ◽  
Reservoir Function
Sign in / Sign up

Export Citation Format

Share Document