scholarly journals Pharmacological Interventions Effective in Improving Exercise Capacity in Heart Failure

2018 ◽  
Vol 4 (1) ◽  
pp. 1 ◽  
Author(s):  
Cristiana Vitale ◽  
Ilaria Spoletini ◽  
Giuseppe MC Rosano
Keyword(s):  
Heart Failure ◽  
Exercise Capacity ◽  
Pharmacological Interventions

Exercise Capacity in Chronic Heart Failure

2012 ◽  
Vol 9 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Gina G Mentzer ◽  
Alex J Auseon
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Exercise Training ◽  
Exercise Capacity ◽  
Positive Impact ◽  
Pharmacologic Therapy ◽  
The Past ◽  
Diagnosis And Prognosis ◽  
Future Therapy

Heart failure (HF) affects more than 5 million people and has an increasing incidence and cost burden. Patients note symptoms of dyspnea and fatigue that result in a decreased quality of life, which has not drastically improved over the past decades despite advances in therapies. The assessment of exercise capacity can provide information regarding patient diagnosis and prognosis, while doubling as a potential future therapy. clinically, there is acceptance that exercise is safe in hf and can have a positive impact on morbidity and quality of life, although evidence for improvement in mortality is still lacking. specific prescriptions for exercise training have not been developed because many variables and confounding factors have prevented research trials from demonstrating an ideal regimen. Physicians are becoming more aware of the indices and goals for hf patients in exercise testing and therapy to provide comprehensive cardiac care. it is further postulated that a combination of exercise training and pharmacologic therapy may eventually provide the most benefits to those suffering from hf.

scholarly journals Regional muscle-adipose distribution is different in patients with heart failure with preserved or reduced ejection fraction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H Ishikawa ◽  
Y Izumiya ◽  
A Shibata ◽  
T Yoshida ◽  
H Hayashi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Body Mass Index ◽  
Adipose Tissue ◽  
Ejection Fraction ◽  
Exercise Capacity ◽  
Exercise Tolerance ◽  
The Other ◽  
Reduced Ejection Fraction ◽  
Significant Difference ◽  
Regional Muscle

Abstract Background Epicardial adipose tissue (EAT) has been recognized to contribute inflammatory activity and atherosclerosis. On the other hand, it has been reported that the volume of EAT is lower in non-ischemic heart failure (HF) patients than healthy individuals. However, the difference in regional muscle-adipose distribution including EAT between HF with preserved ejection fraction (HFpEF) and HF reduced ejection fraction (HFrEF) has not been investigated. In addition, we investigated whether distribution of body composition contributed to exercise capacity. Methods The study included 105 non-ischemic HF patients diagnosed by cardiac catheterization between September 2017 and November 2019. Epicardial, abdominal and thigh muscle and adipose tissue volume were measured by computed tomography (CT), and exercise tolerance was evaluated by symptom-limited cardiopulmonary exercise test. Results Patients were divided into 2 groups according to the left ventricular ejection fraction, ≥40% as HFpEF (n=28) or <40% as HFrEF (n=77). There was no significant difference comorbidity, including hypertension, dyslipidemia, chronic kidney disease, and body mass index. Plasma B-type natriuretic peptide level was significantly higher in HFrEF than HFpEF group (146.2 vs 393.2 pg/ml, p<0.01), whereas, high-sensitive troponin T level was not different between two groups. Although there was no significant difference in BMI between two groups, the volume of EAT was significantly higher in HFpEF than HFrEF group (81.8 vs 136.4 ml, p=0.01). On the other hand, HFpEF had more thigh adipose tissue compared with HFrEF group (54.6 vs 42.1 ml, p=0.03). There were negative correlations between EAT volume and parameters of exercise capacity such as anaerobic threshold (r=−0.42, p<0.01) and peak VO2 (r=−0.32, p<0.01). Muscle volume itself does not corelate with these parameters. Conclusion In patient with nonischemic HF, the pattern of regional adipose distribution may have important role in pathologically. HFpEF and HFrEF has different pattern despite similar body mass index. These differences may be related to impaired exercise tolerance in these 2 different types of HF. Correlation between EAT and AT, peak VO2 Funding Acknowledgement Type of funding source: None

Increased Dead Space Ventilation Mediates Reduced Exercise Capacity in Systolic Heart Failure

2016 ◽  
Vol 193 (11) ◽  
pp. 1292-1300 ◽  
Author(s):  
Kirk Kee ◽  
Christopher Stuart-Andrews ◽  
Matthew J. Ellis ◽  
Jeremy P. Wrobel ◽  
Kris Nilsen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Capacity ◽  
Dead Space ◽  
Systolic Heart Failure ◽  
Dead Space Ventilation

scholarly journals Limited contractile reserve contributes to poor peak exercise capacity in iron-deficient heart failure

2017 ◽  
Vol 20 (4) ◽  
pp. 806-808 ◽  
Author(s):  
Pieter Martens ◽  
Frederik H. Verbrugge ◽  
Petra Nijst ◽  
Matthias Dupont ◽  
Wilfried Mullens
Keyword(s):  
Heart Failure ◽  
Exercise Capacity ◽  
Peak Exercise ◽  
Contractile Reserve ◽  
Iron Deficient
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