Clinical and Diagnostic Aspects of Takotsubo Cardiomyopathy

2011 ◽  
Vol 3 (1) ◽  
pp. 60
Author(s):  
Yoshihiro J Akashi ◽  
Giuseppe Barbaro ◽  
Fumihiko Miyake ◽  
◽  
◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Takotsubo Cardiomyopathy ◽  
Elderly Women ◽  
Apical Ballooning ◽  
Left Ventricular ◽  
Anterior Myocardial Infarction ◽  
Diagnostic Aspects ◽  
The World ◽  
Ventricular Rupture

In recent years, the number of documented cases of takotsubo cardiomyopathy, which occurs mainly in elderly women, has been increasing all over the world. Takotsubo cardiomyopathy presents quite similar symptoms to acute anterior myocardial infarction, but with normal coronary arteries and left ventricular apical ballooning. Takotsubo cardiomyopathy has been recognised as a source of acute heart failure, lethal ventricular arrhythmia and ventricular rupture. The onset mechanism of this syndrome is still a matter of debate. In this article, we summarise previous studies and future issues regarding takotsubo cardiomyopathy.

scholarly journals Clinical Study of The Early Application of Lvabradine For Acute Anterior Myocardial Infarction Patients After PCI With Early Heart Failure To Observe Cardiac Function And Prognosis

2021 ◽  
Author(s):  
Jun-Qing Gao ◽  
Xu wang ◽  
Ling-Yan Li ◽  
Hua Zhang ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Heart Function ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Anterior Myocardial Infarction ◽  
Standard Drug ◽  
End Diastolic Volume ◽  
Percutaneous Coronary

Abstract BackgroundThe incidence of acute myocardial infarction is increasing each year. Percutaneous coronary intervention has become highly preferred for patients with acute myocardial infarction because it not traumatic and improves heart function. However, the mortality and disability rates are still high. For the first time, we used ivabradine in patients with acute anterior myocardial infarction. We expect that this new method will enhance heart function and clinical prognosis because of heart rate control, decreases in heart preload and improvements in left ventricular end-diastolic volume.Method and analysisThis is a prospective, randomized, controlled, open-label, multicenter and optimally designed clinical trial. A total of 500 patients with acute anterior myocardial infarction after Percutaneous coronary intervention（PCI）with early heart failure will be enrolled. Eligible subjects will be randomized at a 1:1 ratio to take the standard drug treatment or receive the standard drug treatment plus ivabradine. The primary outcome measure is left ventricular end-diastolic volume. Left ventricular ejection fraction, adverse cardiac events, and the Canadian angina pectoris score will be evaluated as secondary endpoints. Blood biochemical testing will be used as the safety endpoints. Ethics and dissemination The clinical research will be carried out in strict accordance with the relevant Chinese laws and regulations, the Declaration of Helsinki, and the ethical and scientific principles stipulated by the Chinese GCP. All participants will provide informed consent. The personal information of patients will be kept confidential. Findings from the trial will be disseminated through peer-reviewed journals and scientific conferences.ClinicalTrials.govID:ChiCTR2000032731,Registered8May,2020 http://www.chictr.org.cn/showproj.aspx?proj=53275 Trial Statusversion number: Protocol version 1.0., approved9 May，2020Trial ongoingStudy execute time: From 1 September 2020 to 31 Octomber 2022Recruiting time: From 8 May 2020 to 31 December 2022

scholarly journals Takotsubo Cardiomyopathy in Two Patients without Any Cardiac Symptom on Maintenance Hemodialysis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Jun Muratsu ◽  
Atsuyuki Morishima ◽  
Hiroyasu Ueda ◽  
Hisatoyo Hiraoka ◽  
Katsuhiko Sakaguchi
Keyword(s):  
Myocardial Infarction ◽  
Chest Pain ◽  
Takotsubo Cardiomyopathy ◽  
Clinical Symptoms ◽  
Apical Ballooning ◽  
Left Ventricular ◽  
Maintenance Hemodialysis ◽  
Cardiac Symptom ◽  
Electrocardiographic Changes ◽  
Artery Disease

Takotsubo cardiomyopathy is a disorder characterized by left ventricular apical ballooning and electrocardiographic changes in the absence of coronary artery disease. While reversible in many cases, the mechanism of this disorder remains unclear. The most frequent clinical symptoms of takotsubo cardiomyopathy on admission are chest pain and dyspnea, resembling acute myocardial infarction. Here, we describe two cases of takotsubo cardiomyopathy without chest pain or dyspnea in patients on maintenance hemodialysis. The asymptomatic nature of these two cases may be due to the patients being on hemodialysis. Periodic electrocardiograms (ECG) may be helpful in screening this population for asymptomatic takotsubo cardiomyopathy and in evaluating its incidence.

scholarly journals Myocardial Infarction or Takotsubo Cardiomyopathy? A Case Report of a Rare Clinical Dilemma in the Setting of Atrial Myxoma

2021 ◽  
Author(s):  
Balasubramaniyan Amirtha Ganesh ◽  
Sasinthar Rangasamy ◽  
Arumugam Aashish ◽  
Selvaraj Karthikeyan
Keyword(s):  
Myocardial Infarction ◽  
Takotsubo Cardiomyopathy ◽  
Acute Chest Pain ◽  
Apical Ballooning ◽  
Left Ventricular ◽  
Atrial Myxoma ◽  
Lv Function ◽  
St Segment Elevation ◽  
Coronary Embolization ◽  
Clinical Dilemma

Abstract Background Acute myocardial infarction (AMI) secondary to coronary embolization is one of the rare complications of atrial myxoma. Takotsubo cardiomyopathy (TCM), a close mimic of AMI, is extremely rare in the setting of atrial myxoma. We report a patient with atrial myxoma presenting with features leading to a clinical dilemma between these two entities. Case summary  A 60-year-old woman presented with acute chest pain with ST segment elevation. Echocardiogram revealed left ventricular (LV) apical ballooning which is typical of TCM, coexisting with a fragile left atrial mass. Emergency coronary angiogram showed a hazy lesion in the circumflex ostium and an intermediate lesion in ramus without any obstruction. Surgical excision of the tumor was done due to features of recurrent coronary embolism. The histopathology examination confirmed it as a myxoma. Regional wall motion abnormalities reversed within a month and LV function normalized. Cardiac magnetic resonance (CMR) imaging at follow-up suggested myocardial infarction. Discussion TCM can occur very rarely in the setting of atrial myxoma. In a patient with atrial myxoma presenting with features of TCM, differentiating it from coronary embolization is important.

scholarly journals ‘Acute micro-coronary syndrome’: detailed coronary physiology in a patient with Takotsubo cardiomyopathy

2019 ◽  
Vol 12 (8) ◽  
pp. e229618
Author(s):  
Andrew J Morrow ◽  
Sabrina Nordin ◽  
Patrick O’Boyle ◽  
Colin Berry
Keyword(s):  
Myocardial Infarction ◽  
Takotsubo Cardiomyopathy ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Apical Ballooning ◽  
Left Ventricular ◽  
Fractional Flow ◽  
Coronary Physiology ◽  
Coronary Syndrome ◽  
Flow Reserve

Takotsubo cardiomyopathy (TC), otherwise known as stress cardiomyopathy, is characterised by acute, transient left ventricular systolic dysfunction with apical ballooning in the absence of obstructive epicardial coronary stenosis. The presentation of TC mimics that of acute myocardial infarction. More recently there has been a shift towards thinking of TC as a ‘microvascular acute coronary syndrome’. Our case is of an 82-year-old woman who presented with TC mimicking acute anterior ST elevation myocardial infarction in the context of sepsis. Slow flow noted in the left anterior descending artery prompted us to perform coronary physiology. Her fractional flow reserve was 0.91, with an index of myocardial resistance of 117 and a coronary flow reserve of 1.6. In combination these results are indicative of microvascular coronary dysfunction in the absence of significant epicardial stenosis.

scholarly journals Inferior ST-Elevation Myocardial Infarction Associated with Takotsubo Cardiomyopathy

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Oliver Koeth ◽  
Uwe Zeymer ◽  
Rudolf Schiele ◽  
Ralf Zahn
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Takotsubo Cardiomyopathy ◽  
Clinical Symptoms ◽  
Significant Coronary Artery Disease ◽  
Apical Ballooning ◽  
Left Ventricular ◽  
St Elevation Myocardial Infarction ◽  
St Elevation ◽  
Artery Disease

Takotsubo cardiomyopathy (TCM) is usually characterized by transient left ventricular apical ballooning. Due to the clinical symptoms which include chest pain, electrocardiographic changes, and elevated myocardial markers, Takotsubo cardiomyopathy is frequently mimicking ST-elevation myocardial infarction in the absence of a significant coronary artery disease. Otherwise an acute occlusion of the left anterior descending coronary artery can produce a typical Takotsubo contraction pattern. ST-elevation myocardial infarction (STEMI) is frequently associated with emotional stress, but to date no cases of STEMI triggering TCM have been reported. We describe a case of a female patient with inferior ST-elevation myocardial infarction complicated by TCM.

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