Adverse Pulmonary Responses to Aspirin and Acetaminophen in Chronic Childhood Asthma

PEDIATRICS ◽  
1983 ◽  
Vol 71 (3) ◽  
pp. 313-318
Author(s):  
Thomas J. Fischer ◽  
Timothy D. Guilfoile ◽  
Hemant H. Kesarwala ◽  
John G. Winant ◽  
Gregory L. Kearns ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Flow Rate ◽  
Past History ◽  
Forced Expiratory Volume ◽  
Base Line ◽  
Double Blind ◽  
Asthmatic Children ◽  
Significant Difference ◽  
History Of ◽  
Expiratory Flow

Because aspirin (ASA) is often reported to have an adverse effect on pulmonary function in children with chronic asthma, acetaminophen is commonly used as an ASA substitute in these children. To study acetaminophen effects on pulmonary functions, double-blind, oral challenges of ASA (600 mg), acetaminophen (600 mg), or lactose were administered on separate days to 25 chronic asthmatics, ten boys and 15 girls, ranging in age from 8 to 18 years (mean age ± 1 SD: 12.5 ± 2.8 years). No patient had a past history of adverse reactions to either drug. Forced expiratory volume in 1 second (FEV1), peak expiratory flow rate (PEFR), maximal mid-expiratory flow rate (FEF25-75), forced vital capacity (FVC), maximal voluntary ventilation (MVV), and flow volume curves were measured at base line and ½, 1, 2, 3, and 4 hours after ingestion of drug or placebo. Persistent decreases from base line FEV1 (> 20%) or FEF25-75 (> 30%) occurred in four ASA- and two acetaminophen-challenged patients. One ASA-sensitive patient was placebo intolerant; another reacted to acetaminophen. The acetaminophen responses were of less intensity than the ASA responses. Analysis of group mean pulmonary function responses to ASA, acetaminophen, and lactose showed no significant difference among the three agents at any time. Aspirin should be used cautiously in asthmatic children. Acetaminophen appears to be an adequate, although not completely, innocuous ASA substitute.

Wheezing in Infants with Cystic Fibrosis: Clinical Course, Pulmonary Function, and Survival Analysis

PEDIATRICS ◽  
1992 ◽  
Vol 90 (5) ◽  
pp. 703-706
Author(s):  
Joseph Reisman ◽  
Mary Corey ◽  
Gerard Canny ◽  
Henry Levison ◽  
Eitan Kerem ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Flow Rate ◽  
Forced Expiratory Volume ◽  
Common Finding ◽  
Study Cohort ◽  
Expiratory Phase ◽  
Significant Difference ◽  
Forced Expiratory Flow ◽  
Expiratory Flow

Wheezing is a common finding in infants with cystic fibrosis (CF). This study was undertaken to determine the prevalence of wheezing in infants with CF and to compare the clinical outcome of those who wheezed in infancy with that of those who did not. The study cohort included 229 CF patients born between 1965 and 1979 with CF diagnosed before 2 years of age. Fifty-seven (25%) had physician-documented wheezing during the first 2 years of life. Wheezing had resolved by the age of 2 years in 50% of the patients and by the age of 4 years in 75%. Although wheezing seemed to be linked to a family history of allergy and asthma, the frequency of the ΔF508 mutation was similar to that of the non-wheezers. There was no significant difference in survival at the age of 13 years between the two groups. At the age of 7 years, patients who had wheezed had significantly lower forced expiratory flow rate at mid-expiratory phase (85 ± 34% predicted) compared with those with no wheezing history (101 ± 34% predicted). At the age of 13 years, forced expiratory volume in 1 second values was lower in the wheezing group (69 ± 24% predicted vs 78 ± 21% predicted), as was forced expiratory flow rate at mid-expiratory phase (56 ± 33% predicted vs 69 ± 30% predicted). In conclusion, although wheezing in infants with CF seems to have diminished with age, pulmonary function abnormalities were more evident at 7 and 13 years of age in the group that wheezed than in the group that did not.

Effects of low concentrations of chlorine on pulmonary function in humans

1983 ◽  
Vol 54 (4) ◽  
pp. 1120-1124 ◽  
Author(s):  
H. H. Rotman ◽  
M. J. Fliegelman ◽  
T. Moore ◽  
R. G. Smith ◽  
D. M. Anglen ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Flow Rate ◽  
Vital Capacity ◽  
Nitrogen Concentration ◽  
Forced Expiratory Volume ◽  
Base Line ◽  
Percent Change ◽  
Low Concentrations ◽  
Sham Exposure ◽  
Expiratory Flow

Eight healthy unacclimated volunteers were exposed to chlorine gas in concentrations of 0.5 or 1 ppm, and several pulmonary function measurements were made. Comparisons were made by paired t test between the percent change from base-line values obtained at various times after chlorine exposure and the percent change from base line at analogous times after a sham exposure. With the sham vs. 0.5-ppm exposure, there were trivial changes observed. Total lung capacity (TLC) was lower before 0.5-ppm exposure than before sham exposure, and the percent decrease in carbon dioxide pulmonary diffusing capacity was smaller 24 h after 0.5-ppm exposure than 24 h after sham exposure. With the sham vs. 1-ppm exposure, there were many differences in percent change from base line that were significant at the P less than 0.05 level or better. These were in forced vital capacity (FVC), forced expiratory volume at 1 s (FEV1), peak expiratory flow rate (PEFR), forced expiratory flow rate at 50 and 25% vital capacity (FEF50 and FEF25, respectively), and airway resistance (Raw). There were, in addition, significant changes after only 4 h of exposure. These were in FEV1, PEFR, FEF50, FEF25, TLC, Raw, and the difference in nitrogen concentration. Most of the test results had returned to normal by the next day. We conclude that even though chlorine at low concentrations does not produce any serious subjective symptoms, it adversely affects pulmonary function transiently.

In-brace alterations of pulmonary functions in adolescents wearing a brace for idiopathic scoliosis

2019 ◽  
Vol 43 (4) ◽  
pp. 434-439 ◽  
Author(s):  
Gozde Yagci ◽  
Gokhan Demirkiran ◽  
Yavuz Yakut
Keyword(s):  
Idiopathic Scoliosis ◽  
Pulmonary Function ◽  
Peak Expiratory Flow ◽  
Forced Vital Capacity ◽  
Respiratory Muscle ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Pulmonary Functions ◽  
Significant Difference ◽  
Expiratory Flow

Background:Despite the common use of braces to prevent curve progression in idiopathic scoliosis, their functional effects on respiratory mechanics have not been widely studied.Objective:The objective was to determine the effects of bracing on pulmonary function in idiopathic scoliosis.Methods:A total of 27 adolescents with a mean age of 14.5 ± 1.5 years and idiopathic scoliosis were included in the study. Pulmonary function evaluation included vital capacity, forced expiratory volume, forced vital capacity, maximum ventilator volume, peak expiratory flow, and respiratory muscle strengths, measured with a spirometer, and patient-reported degree of dyspnea. The tests were performed once prior to bracing and at 1 month after bracing (while the patients wore the brace).Results:Compared with the unbraced condition, vital capacity, forced expiratory volume, forced vital capacity, maximum ventilator volume, and peak expiratory flow values decreased and dyspnea increased in the braced condition. Respiratory muscle strength was under the norm in both unbraced and braced conditions, while no significant difference was found for these parameters between the two conditions.Conclusion:The spinal brace for idiopathic scoliosis tended to reduce pulmonary functions and increase dyspnea symptoms (when wearing a brace) in this study. Special attention should be paid in-brace effects on pulmonary functions in idiopathic scoliosis.Clinical relevanceBracing seems to mimic restrictive pulmonary disease, although there is no actual disease when the brace is removed. This study suggests that bracing may result in a deterioration of pulmonary function when adolescents with idiopathic scoliosis are wearing a brace.

scholarly journals Faal Paru Dinamis

2019 ◽  
Vol 3 (3) ◽  
pp. 89
Author(s):  
Arief Bakhtiar ◽  
Renny Irviana Eka Tantri
Keyword(s):  
Pulmonary Function ◽  
Respiratory Distress ◽  
Flow Rate ◽  
Forced Vital Capacity ◽  
Lung Development ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Accuracy Level ◽  
Expiratory Flow ◽  
Central Airway

Pulmonary function is an examination to measure lung volume function using spirometry. Tests with spirometry to detect abnormalities associated with respiratory distress. Spirometry examination is not only to determine the diagnosis but also to assess the severity of obstruction, restriction, and the effects of treatment. Spirometry examination is a test to measure the volume of a person’s static and dynamic lungs with a spirometer tool. Dynamic lung spirometry consists of Forced vital capacity (FVC), Forced expiratory volume (FEVT), Forced expiratory flow200-1200 / FEF 200-1200, Forced expiratory flow25% -75% / FEF 25% -75%, Peak expiratory flow rate / PEFR, Maximum voluntary ventilation / MVV / MBC, FEV1 / FVC Ratio. Ventilation disorders consist of: restriction and obstruction disorders. Restriction is a disorder of lung development by any cause. In obstruction disorder, it shows a decrease in velocity of expiratory flow and normal vital capacity. FEV values, which are widely used are FEV1 / FVC, abnormal when <80%, FEV1 / FVC ratio <80%. This parameter is very important because the accuracy level for obstruction in the central airway is quite large. In obstructive disorder there is generally a decrease in pulmonary dynamic volume. Significant parameters are FEV 1 / FVC, PEFR, and FEF 25-75. The FEV1 / FVC ratio is important because the accuracy level for obstruction in the central airway is considerable, whereas FEF 25-75 indicates obstruction in the small airway.

scholarly journals Peak Expiratory Flow Rate in Pregnant Women

1970 ◽  
Vol 2 ◽  
pp. 20-23
Author(s):  
Dipok Kumar Sunyal ◽  
Md Ruhul Amin ◽  
Abeda Ahmed ◽  
Shameema Begum ◽  
M Begum ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Study Group ◽  
Medical College ◽  
Significant Difference ◽  
History Of ◽  
Expiratory Flow ◽  
Predicted Values

In the present study peak expiratory flow rate (PEFR) were estimated in pregnant women during different trimester to observe the alteration in air flow rate during pregnancy. This study was carried out in the department of Physiology of Dhaka Medical College from July 2004 to June 2005. For this purpose, total 100 women with age ranged from 25 years to 35 years without any recent history of respiratory diseases were selected and divided into 25 healthy non-pregnant women as control and 75 normal pregnant women as study group. Study group was further divided into 25 in first trimesters, 25 in second trimester and 25 in third trimesters of pregnancy. All the subjects belonged to lower socioeconomic class. The PEFR was estimated by using an automatic spirometer. The measured values and percentage of predicted values of PEFR were estimated during the 1st, 2nd, 3rd trimesters of pregnant women and non-pregnant women. Statistical analysis of data were done by un paired student's ‘t'test. The PEFR was significantly lower in both 2nd and 3rd trimester pregnant women than that of non-regnant women. Again the PEFR was significantly lower in 3rd trimester than that of 1st trimester of pregnant women. There were no statistically significant difference of PEFR between the non-pregnant and 1st trimester; between the 1st trimester and 2nd trimeste; and between the 2nd trimester and 3rd trimester of pregnant women. It may be concluded that PEFR were progressively decreased throughout the pregnancy, most likely due to mechanical effects of progressively increased size of uterus that progressively decreases lung volumes and capacities. Key Words: Expiratory Flow Rate, Pregnancy, Uterus DOI:10.3329/jbsp.v2i0.979 J Bangladesh Soc Physiol. 2007 Dec;(2): 20-23.

Do Deeper Levels of Cervical Biopsies Preceded by a Pap Smear Diagnosis of LSIL, ASCUS, or NILM/HPV+ Increase the Yield of Identifying Clinically Significant Lesions?

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S163-S164
Author(s):  
K G Manjee ◽  
W G Watkin
Keyword(s):  
Pap Smear ◽  
Past History ◽  
Prior History ◽  
Cervical Biopsy ◽  
P16 Immunohistochemistry ◽  
Hpv Status ◽  
Significant Difference ◽  
History Of ◽  
Clinically Significant ◽  
Almost All

Abstract Introduction/Objective Cervical biopsy is performed following an abnormal pap smear or positive HPV testing in an attempt to uncover clinically significant lesions [HSIL/invasive carcinoma (HSIL+)]. An excisional procedure is considered if biopsy confirms HSIL+. When preceded by pap smear of LSIL, ASCUS, NILM/HPV+ or persistent HPV, continued surveillance is recommended for biopsies showing no SIL or LSIL. In our laboratory, cervical biopsies are routinely sectioned at 3 levels. Deeper levels are often ordered when initial sections are non-diagnostic. p16 immunohistochemistry, with or without deeper levels, is often ordered to confirm HSIL, or to differentiate HSIL from mimics. In this study, we examine whether and in what clinical situations does obtaining additional levels uncover clinically significant lesions. Methods 430 cervical biopsies between January-May 2018, with recent cytology of LSIL, ASCUS or NILM/HPV+ were identified in the pathology database. HPV status (if known), final biopsy diagnosis and past history of LSIL/HSIL were recorded. For each biopsy, orders for additional levels and/or p16 immunohistochemistry were recorded resulting in 4 categories: C1-no additional levels or p16, C2-deeper only, C3-deeper+p16 and C4-p16 only. Final diagnoses were divided into HSIL+, LSIL and no SIL. Results There was no significant difference in prior history of LSIL/HSIL and HPV status between all categories. Biopsy results were as follows: HSIL+: 11/222 (5%) C1; 1/78 (1%) C2; 7/43 (16%) C3; 15/87 (17%) C4 LSIL: 91/222 (41%) C1; 7/78 (9%) C2; 16/43 (37%) C3; 35/87 (40%) C4 No SIL: 120/222 (54%) C1; 70/78 (90%) C2; 20/43 (46%) C3; 37/87 (42%) C4 The average number of additional levels in C2 and C3 was 3.8 and 1.8, respectively. Conclusion Deeper levels alone did not enhance the detection of HSIL+. Almost all LSIL/HSIL were detected when initial levels were diagnostic or suspicious and supported by p16 immunohistochemistry. 3 levels are adequate to detect clinically significant lesions.

Operant muscular relaxation and peak expiratory flow rate in asthmatic children

1978 ◽  
Vol 22 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Harry Kotses ◽  
Kathleen D. Glaus ◽  
Stanley K. Bricel ◽  
Jack E. Edwards ◽  
Paul L. Crawford
Keyword(s):  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Muscular Relaxation ◽  
Asthmatic Children ◽  
Expiratory Flow

Inhaled Terbutaline Administered via a Spacer Fully Prevents Exercise-Induced Asthma in Young Asthmatic Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

1989 ◽  
Vol 17 (6) ◽  
pp. 506-513 ◽  
Author(s):  
A.T. Dinh Xuan ◽  
C. Lebeau ◽  
R. Roche ◽  
A. Ferriere ◽  
M. Chaussain
Keyword(s):  
Room Temperature ◽  
Work Load ◽  
Cycle Ergometer ◽  
Forced Expiratory Volume ◽  
Controlled Study ◽  
Adrenergic Agonist ◽  
Double Blind ◽  
Asthmatic Children ◽  
Exercise Induced ◽  
Age Range

The effects of inhaled terbutaline, a β2-adrenergic agonist, administered via a 750-ml spacer device were studied in young asthmatic subjects with exercise-induced asthma. A double-blind, randomized, placebo-controlled study of the effects of inhaled 0.5 mg terbutaline and placebo was conducted in 10 asthmatic children (age range 6–16 years) with documented exercise-induced asthma. Forced expiratory volume in 1 s (FEV1) was measured at baseline, 15 min after inhaling terbutaline or placebo, and at intervals up to 60 min after exercising. Subjects exercised using a cycle ergometer for 5 min at a submaximal, constant work-load while breathing dry air at room temperature. Terbutaline induced bronchodilation at rest in all subject and fully prevented exercise-induced asthma in nine out of the 10 subjects; the exercise-induced fall in FEV1 was markedly reduced in the remaining subject. It is concluded that exercise-induced asthma can be inhibited by pretreatment with inhaled terbutaline, administered via a spacer, in a majority of young asthmatics.

Pulmonary function in men after oxygen breathing at 3.0 ATA for 3.5 h

1991 ◽  
Vol 71 (3) ◽  
pp. 878-885 ◽  
Author(s):  
J. M. Clark ◽  
R. M. Jackson ◽  
C. J. Lambertsen ◽  
R. Gelfand ◽  
W. D. Hiller ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Large Change ◽  
Forced Expiratory Volume ◽  
Diffusing Capacity ◽  
Mild Degree ◽  
Oxygen Breathing ◽  
Multiple Organs ◽  
Expiratory Flow

As a pulmonary component of Predictive Studies V, designed to determine O2 tolerance of multiple organs and systems in humans at 3.0–1.5 ATA, pulmonary function was evaluated at 1.0 ATA in 13 healthy men before and after O2 exposure at 3.0 ATA for 3.5 h. Measurements included flow-volume loops, spirometry, and airway resistance (Raw) (n = 12); CO diffusing capacity (n = 11); closing volumes (n = 6); and air vs. HeO2 forced vital capacity maneuvers (n = 5). Chest discomfort, cough, and dyspnea were experienced during exposure in mild degree by most subjects. Mean forced expiratory volume in 1 s (FEV1) and forced expiratory flow at 25–75% of vital capacity (FEF25–75) were significantly reduced postexposure by 5.9 and 11.8%, respectively, whereas forced vital capacity was not significantly changed. The average difference in maximum midexpiratory flow rates at 50% vital capacity on air and HeO2 was significantly reduced postexposure by 18%. Raw and CO diffusing capacity were not changed postexposure. The relatively large change in FEF25–75 compared with FEV1, the reduction in density dependence of flow, and the normal Raw postexposure are all consistent with flow limitation in peripheral airways as a major cause of the observed reduction in expiratory flow. Postexposure pulmonary function changes in one subject who convulsed at 3.0 h of exposure are compared with corresponding average changes in 12 subjects who did not convulse.

scholarly journals Does Ramadan Fasting Affect Spirometric Data of Healthy Adolescents?

2019 ◽  
Vol 13 ◽  
pp. 117955651986228
Author(s):  
Selma Ben Fraj ◽  
Amira Miladi ◽  
Fatma Guezguez ◽  
Mohamed Ben Rejeb ◽  
Jihène Bouguila ◽  
...  
Keyword(s):  
Experimental Study ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Healthy Male ◽  
Ramadan Fasting ◽  
Male Adolescents ◽  
Significant Difference ◽  
Quasi Experimental ◽  
Expiratory Flow ◽  
Healthy Males

Purpose: Several studies raised the effects of Ramadan fasting on healthy adults spirometric data, but none was performed in children. The aim of this study was to compare the spirometric data of a group of faster adolescents (n = 26) with an age-matched non-faster one (n = 10). Methods: This comparative quasi-experimental study, including 36 healthy males aged 12 to 15 years, was conducted during the summer 2015 (Ramadan: June 18 to July 16). Three sessions (Before-Ramadan [Before-R], Mid-Ramadan [Mid-R], After-Ramadan [After-R]) were selected for spirometry measurements. Spirometry was performed around 5.5 to 3.5 h before sunset and the spirometric data were expressed as percentages of local spirometric norms. Results: The two groups of fasters and non-fasters had similar ages and weights (13.35 ± 0.79 vs 12.96 ± 0.45 years, 46.8 ± 9.2 vs 41.7 ± 12.6 kg, respectively). There was no effect of Ramadan fasting on forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, peak expiratory flow, and maximal mid-expiratory flow. For example, during the Before-R, Mid-R, and After-R sessions, there was no significant difference between the fasters and non-fasters mean FVC (101 ± 11 vs 99 ± 14, 101 ± 12 vs 102 ± 14, 103 ± 11 vs 104 ± 13, respectively) or FEV1 (101 ± 13 vs 96 ± 16, 98 ± 11 vs 97 ± 16, 101 ± 10 vs 98 ± 16, respectively). Conclusions: Ramadan fasting had no interaction effect with the spirometric data of Tunisian healthy male adolescents.

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