Caution in Oxygen Therapy to Prevent Retrolental Fibroplasia

PEDIATRICS ◽  
1956 ◽  
Vol 18 (3) ◽  
pp. 511-511
Author(s):  
V. EVERETT KINSEY
Keyword(s):  
Premature Infants ◽  
Oxygen Therapy ◽  
Clinical Symptoms ◽  
Retrolental Fibroplasia ◽  
The Past

The recommendation that oxygen be restricted in the care of premature infants to that amount indicated by clinical symptoms, and then that it be given only in concentrations below 40%, is being made by more and more medical and lay agencies. I am in full accord with this recommendation, and following it has unquestionably reduced the incidence of retrolental fibroplasia (RLF) to a significant and encouraging extent. Over the past few months, however, I have learned that a number of pediatricians have gained the impression that there is appreciably less risk of developing RLF if oxygen is administered at less than 40% concentration.

Oxygen Therapy and Survival Rate in Prematures

PEDIATRICS ◽  
1957 ◽  
Vol 19 (5) ◽  
pp. 967-967
Author(s):  
HARRY H. GORDON
Keyword(s):  
Survival Rate ◽  
Premature Infants ◽  
Oxygen Therapy ◽  
Cooperative Study ◽  
Retrolental Fibroplasia

To the Editor: The recent publication (Pediatrics, 18: 511, 1956) of a caution on the use of oxygen in the care of premature infants prompts this letter. Although the Cooperative Study of Retrolental Fibroplasia confirmed, beyond question of even the most skeptical, previously published reports of investigators from many countries that excessive use of oxygen caused retrolental fibroplasia, the conclusions reached concerning the relation of oxygen restriction to survival rate of the infants are not clear.

Retrolental Fibroplasia and Factors Influencing Oxygen Transport

PEDIATRICS ◽  
1977 ◽  
Vol 59 (6) ◽  
pp. 916-918
Author(s):  
David Lechner ◽  
Robert E. Kalina ◽  
W. Alan Hodson
Keyword(s):  
Birth Weight ◽  
Premature Infants ◽  
Oxygen Transport ◽  
Gestational Age ◽  
Oxygen Therapy ◽  
Blood Transfusions ◽  
Hospital Records ◽  
Retrolental Fibroplasia ◽  
Factors Influencing ◽  
Significant Difference

The hospital records of 58 premature infants in whom proliferative retrolental fibroplasia (RLF) developed were matched with the records of 58 infants without RLF for birth weight, gestational age, and duration of oxygen therapy. The two groups were compared for factors likely to influence tissue delivery of oxygen by blood. No significant difference was found in incidence of blood transfusions or exchange transfusions, use of phototherapy, or occurrence of acidosis.

Does Carbon Dioxide Play a Role in Retrolental Fibroplasia?

PEDIATRICS ◽  
1982 ◽  
Vol 70 (3) ◽  
pp. 500-501
Author(s):  
M. L. Wolbarsht ◽  
Gregory S. George ◽  
Jan Kylstra ◽  
M. B. Landers
Keyword(s):  
Carbon Dioxide ◽  
Clinical Research ◽  
Premature Infants ◽  
Oxygen Therapy ◽  
Supplemental Oxygen ◽  
Retrolental Fibroplasia ◽  
High Concentrations ◽  
Supplemental Oxygen Therapy

Gordon et al1 were the first to note the association of retrolental fibroplasia (RLF) with the administration of high concentrations of oxygen to premature infants. Since that time, clinical research has demonostrated that RLF can develop in a variety of circumstances. Typically, this retinopathy arises after the cessation of supplemental oxygen therapy to neonates. Currently, the most widely accepted paradigm proposes that the neovascularization of RLF is the immature vascular system's response to a retina that has become hypoxic after the withdrawal of supplemental oxygen.

THE POSSIBILITY OF TOTAL ELIMINATION OF RETROLENTAL FIBROPLASIA BY OXYGEN RESTRICTION

PEDIATRICS ◽  
1956 ◽  
Vol 17 (2) ◽  
pp. 247-249 ◽  
Author(s):  
Loren P. Guy ◽  
Jonathan T. Lanman ◽  
Joseph Dancis
Keyword(s):  
Premature Infant ◽  
Oxygen Therapy ◽  
Oxygen Limitation ◽  
Bellevue Hospital ◽  
Retrolental Fibroplasia ◽  
The Past ◽  
Total Elimination ◽  
Limited Oxygen

No cicatricial retrolental fibroplasia has occurred in any of the 148 infants who have received severely limited oxygen therapy in the Bellevue Hospital Premature Infant Nursery during the past 2½ years. We believe that retrolental fibroplasia can be either completely or almost completely eliminated by administering oxygen only at times of clinical need, and then for as brief periods as possible and at concentrations less than 40 per cent. Mortality rose slightly during the period of oxygen limitation; the rise was not statistically significant. The possibility of a relationship to oxygen limitation is discussed; the writers believe that such a relationship is not likely.

scholarly journals ROP REACTIVATED!

2020 ◽  
Vol Volume 1 (Fall) ◽  
pp. 1-4
Author(s):  
Anisha Rathod ◽  
Karobi Lahiri
Keyword(s):  
Visual Acuity ◽  
Clinical Symptoms ◽  
Tertiary Hospital ◽  
Retrolental Fibroplasia ◽  
The Past ◽  
Black Spots ◽  
History Of ◽  
Symptoms And Signs

Purpose:To report a case of ROP reactivation, later in life following natural regression in infancy.Methods:Prospective study focusing on ocular presentation and outcome of long term ROP follow-up at Tertiary Hospital, India. A 12-year-old female, seen by us first at 8 years of age, with a 6-monthly follow-up with known history of bilateral ROP came with complaints of black spots. The incident occurred after 4 years of follow-up in this patient at our center.On examination, patient had (OD) falciform fold at the macula and (OS) had regressed ROP. Left eye had developed new vascular buds (vessels) along avascular arcade. FFA was done and leaks with non-perfusion areas were noted. Patient didn’t receive any treatment in the past and was on 6 monthly follow-ups.Result:Based on the clinical symptoms and signs, reactivation of ROP was suspected and FFA examination revealed filing defects and leaks. After consent, laser therapy was given to stop the progression .Visual acuity and retina remained steady during the follow-up period. Bone densitometry done on patient showed low calcium levels.Conclusion: Patients with history of ROP treatment with or without active signs should be evaluated lifelong to detect and avert vision threatening complications.Keywords: ROP, Retinopathy of prematurity, retrolental fibroplasia

scholarly journals Application Effect of Acupoint Massage on Zusanli on Premature Infants with Feeding Intolerance and Their Clinical Symptoms

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yueqiu Gong ◽  
Li Zhu
Keyword(s):  
Premature Infants ◽  
Treatment Time ◽  
Clinical Symptoms ◽  
Abdominal Distension ◽  
General Information ◽  
Control Group ◽  
Feeding Intolerance ◽  
Functional Disturbance ◽  
The Past ◽  
Theoretical Support

FI is mainly caused by functional disturbance in premature infants, which greatly poses a threat to their growth and development, so a large number of studies on the clinical features of FI should be conducted to provide theoretical support for treatment. The purpose of the study was to investigate the therapeutic effect of acupoint massage on Zusanli on premature infants with feeding intolerance (FI) and their clinical symptoms. A total of 60 premature infants with FI admitted to our hospital over the past two years were selected as the FI group, and another 60 premature infants without FI were selected as the control group. The birthweight and gestational age of the premature infants in the FI group were significantly lower than those in the control group ( P < 0.001 ), whereas there were no significant differences in general information of the premature infants between the two groups ( P > 0.05 ). Vomiting, abdominal distension, and gastric retention are the main clinical symptoms of premature infants with FI, and acupoint massage on Zusanli combined with routine treatment can effectively improve digestive function, relieve clinical symptoms, and shorten treatment time of premature infants with FI, which is worthy of application and promotion in clinical practice.

RETROLENTAL FIBROPLASIA: THE PEDIATRICIAN'S DILEMMA

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 509-510
Author(s):  
A. Patz ◽  
V. Everett Kinsey
Keyword(s):  
Premature Infants ◽  
Oxygen Therapy ◽  
Hyaline Membrane Disease ◽  
The United States ◽  
Cooperative Study ◽  
Retrolental Fibroplasia ◽  
The World ◽  
Hyaline Membrane ◽  
Short Span ◽  
General Restriction

Retrolental fibroplasia (RLF), which was unknown prior to the early 1940's, was first identified in premature infants by Terry in 1942.1 Within the short span of approximately 10 years, RLF had become one of the major causes of blindness in children throughout the world. The incrimination of oxygen in the early 1950's was demonstrated conclusively in a cooperative study performed in the United States in 1953-54 and published in 1956.2 The results of this study led to the general restriction of oxygen therapy, and the incidence of RLF subsequently decreased dramatically. Avery and Oppenheimer3 in 1960 first reported that the mortality from hyaline membrane disease had increased in their nursery during the period of rigid curtailment of oxygen to prevent RLF.

DIAGNOSIS AND TREATMENT: OXYGEN THERAPY AND RETROLENTAL FIBROPLASIA

PEDIATRICS ◽  
1969 ◽  
Vol 43 (1) ◽  
pp. 88-89
Author(s):  
William A. Silverman
Keyword(s):  
Intensive Care ◽  
American Academy ◽  
Premature Infants ◽  
Clinical Data ◽  
Oxygen Therapy ◽  
Supplemental Oxygen ◽  
Premature Baby ◽  
Retrolental Fibroplasia ◽  
Oxygen Administration ◽  
American Academy Of Pediatrics

The conference succeeded in emphasizing the current importance of increased understanding of mutual problems by pediatricians and ophthalmologists. Premature infants with major illnesses can be treated adequately only in optimally manned and fully equipped intensive care units. Current support for these facilities is woefully inadequate. Ophthalmologists must examine every premature baby receiving supplemental oxygen, and the eyes of children born prematurely should be examined regularly for the first 2 years of life. Participants in the conference agreed that revised recommendations for oxygen administration are highly desirable but that currently available data are insufficient to justify a revision of the present cautious recommendations. A vital need exists for extensive research in these areas, along with the accumulation of considerably more clinical data. Subsequent meetings of this kind are clearly necessary, and it was suggested that the American Academy of Pediatrics should be invited to participate officially in the next meeting.

O TEMPORA, O MORES!1—Cicero

PEDIATRICS ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 42-42
Author(s):  
Keyword(s):  
Premature Infants ◽  
Oxygen Therapy ◽  
Surgical Intervention ◽  
Scleral Buckling ◽  
Double Blind ◽  
Retrolental Fibroplasia ◽  
Group A ◽  
Group B ◽  
Oxygen Group ◽  
Grade Iii

1954: "All premature infants were alternately placed in a group to be [gradually] weaned from oxygen (Group A) and a group to be suddenly withdrawn from oxygen (Group B).... If an infant was thought to be developing the disease [progressive RLF] the infant was placed back in oxygen at the same concentration from which he had been removed. Because our results with oxygen therapy had been uniformly successful, we did not feel it was fair to withhold treatment in order to obtain control cases."2 1981: "We undertook a double-blind clinical study to determine the efficacy of vitamin E in preventing the development of severe retrolental fibroplasia.... Any infant found to have Grade III was removed form the study and treated surgically."3 1981: "In this center, surgical intervention with cryotherapy and scleral buckling procedures have produced favorable responses in RLF cases."4

Scrub typhus (Orientia tsutsugamushi), A rapidly spreading epidemic in Chennai - A standalone lab experience

2016 ◽  
Vol 5 (09) ◽  
pp. 4896
Author(s):  
Sripriya C.S.* ◽  
Shanthi B. ◽  
Arockia Doss S. ◽  
Antonie Raj I. ◽  
Mohana Priya
Keyword(s):  
Scrub Typhus ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Orientia Tsutsugamushi ◽  
The Past ◽  
Igm Elisa ◽  
The Mean ◽  
Specific Symptoms ◽  
Symptoms And Signs

Scrub typhus (Orientia tsutsugamushi), is a strict intracellular bacterium which is reported to be a recent threat to parts of southern India. There is re-emergence of scrub typhus during the past few years in Chennai. Scrub typhus is an acute febrile illness which generally causes non-specific symptoms and signs. The clinical manifestations of this disease range from sub-clinical disease to organ failure to fatal disease. This study documents our laboratory experience in diagnosis of scrub typhus in patients with fever and suspected clinical symptoms of scrub typhus infection for a period of two years from April 2014 to April 2016 using immunochromatography and IgM ELISA methods. The study was conducted on 648 patients out of whom 188 patients were found to be positive for scrub typhus. Results also showed that pediatric (0 -12 years) and young adults (20 – 39 years) were more exposed to scrub typhus infection and female patients were more infected compared to male. The study also showed that the rate of infection was higher between September to February which also suggested that the infection rate is proportional to the climatic condition. Statistical analysis showed that the mean age of the patients in this study was 37.6, standard deviation was 18.97, CV % was 50.45. 

Sign in / Sign up

Export Citation Format

Share Document