Improved Microbial Detection and Identification in Pediatric Bone and Joint Infections

2021 ◽  
Vol 45 (2) ◽  
pp. 19-19
Keyword(s):  
Microbial Detection ◽  
Joint Infections ◽  
Bone And Joint Infections ◽  
Detection And Identification

scholarly journals Viral Bone Infection: A Neglected Disease?

2020 ◽  
Vol 8 (6) ◽  
pp. 797
Author(s):  
Lorenzo Drago ◽  
Carlo L. Romanò ◽  
Ilaria Morelli ◽  
Thami Benzakour
Keyword(s):  
Bone Diseases ◽  
Bone Infection ◽  
Viral Dna ◽  
Neglected Disease ◽  
Joint Infections ◽  
Bone And Joint Infections ◽  
Detection And Identification ◽  
Bone Structures

Bone structures reveal viral DNA/RNA, but little is known of the interaction and pathogenesis of viruses and bone diseases. Their detection and identification is often overlooked and not considered by many clinicians and researchers. In this Editorial, we suggest the role of viruses in some inflammatory bone conditions and their possible role as aetiological agents in bone and joint infections.

scholarly journals Does Vancomycin Resistance Increase Mortality? Clinical Outcomes and Predictive Factors for Mortality in Patients with Enterococcus faecium Infections

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 105
Author(s):  
Jatapat Hemapanpairoa ◽  
Dhitiwat Changpradub ◽  
Sudaluck Thunyaharn ◽  
Wichai Santimaleeworagun
Keyword(s):  
Risk Factors ◽  
Clinical Outcomes ◽  
Proportional Hazards Model ◽  
Significant Risk ◽  
Vancomycin Resistance ◽  
Cox Proportional Hazards Model ◽  
Factors Associated ◽  
Joint Infections ◽  
Bone And Joint Infections ◽  
The Impact

The prevalence of enterococcal infection, especially E. faecium, is increasing, and the issue of the impact of vancomycin resistance on clinical outcomes is controversial. This study aimed to investigate the clinical outcomes of infection caused by E. faecium and determine the risk factors associated with mortality. This retrospective study was performed at the Phramongkutklao Hospital during the period from 2014 to 2018. One hundred and forty-five patients with E. faecium infections were enrolled. The 30-day and 90-day mortality rates of patients infected with vancomycin resistant (VR)-E. faecium vs. vancomycin susceptible (VS)-E. faecium were 57.7% vs. 38.7% and 69.2% vs. 47.1%, respectively. The median length of hospitalization was significantly longer in patients with VR-E. faecium infection. In logistic regression analysis, VR-E. faecium, Sequential Organ Failure Assessment (SOFA) scores, and bone and joint infections were significant risk factors associated with both 30-day and 90-day mortality. Moreover, Cox proportional hazards model showed that VR-E. faecium infection (HR 1.91; 95%CI 1.09–3.37), SOFA scores of 6–9 points (HR 2.69; 95%CI 1.15–6.29), SOFA scores ≥ 10 points (HR 3.71; 95%CI 1.70–8.13), and bone and joint infections (HR 0.08; 95%CI 0.01–0.62) were significant risk factors for mortality. In conclusion, the present study confirmed the impact of VR-E. faecium infection on mortality and hospitalization duration. Thus, the appropriate antibiotic regimen for VR-E. faecium infection, especially for severely ill patients, is an effective strategy for improving treatment outcomes.

Bone and joint infections caused by Clostridium perfringens: a case series

2021 ◽  
Author(s):  
Margaux Visse ◽  
Véronique Vernet-Garnier ◽  
Odile Bajolet ◽  
Delphine Lebrun ◽  
Morgane Bonnet ◽  
...  
Keyword(s):  
Clostridium Perfringens ◽  
Case Series ◽  
Joint Infections ◽  
Bone And Joint Infections

scholarly journals Soft Tissue, Bone, and Joint Infections in People Who Inject Drugs

2020 ◽  
Vol 34 (3) ◽  
pp. 495-509 ◽  
Author(s):  
Carlos S. Saldana ◽  
Darshali A. Vyas ◽  
Alysse G. Wurcel
Keyword(s):  
Soft Tissue ◽  
People Who Inject Drugs ◽  
Joint Infections ◽  
Bone And Joint Infections

scholarly journals Bone and Joint Infections among Hematopoietic Stem Cell Transplant Recipients

2019 ◽  
Vol 4 (5) ◽  
pp. 209-215
Author(s):  
Cybele Lara Abad ◽  
Vania Phuoc ◽  
Prashant Kapoor ◽  
Pritish K. Tosh ◽  
Irene G. Sia ◽  
...  
Keyword(s):  
Stem Cell ◽  
Septic Arthritis ◽  
Hematopoietic Stem Cell ◽  
Joint Infection ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Joint Infections ◽  
Bone And Joint Infections ◽  
Prosthetic Joint ◽  
Increased Risk

Abstract. Background: Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk for infection. This study describes bone and joint infections (BJI) among HSCT recipients.Methods: We reviewed 5861 patients who underwent HSCT at Mayo Clinic, Rochester, MN from January 1, 2005 through January 1, 2015 for study inclusion. BJI was defined as native septic arthritis, prosthetic joint infection, osteomyelitis, and orthopedic implant infection. All adults with BJI after HSCT were included in the analysis.Results: Of 5861 patients, 33 (0.6%) developed BJI. Native joint septic arthritis was the most common BJI occurring in 15/33 (45.4%) patients. Patients were predominantly male (24/33, 72.7%), with median age of 58 (range 20-72) years. BJI was diagnosed a median of 39 (range 1-114) months after allogeneic (14/33, 42.4%) or autologous (19/33, 57.6%) HSCT. Organisms were recovered via tissue (24/27, 88.9%), synovial fluid (13/17, 76.5%), and/or blood cultures (16/25, 64%). Most underwent surgical debridement (23/33, 69.7%). Patients were followed a median of 78.3 months (range 74-119). Therapy was unsuccessful in 4/33 (12.1%), with death related to the underlying BJI in two (50%). Failure occurred a median of 3.4 (0.1-48.5) months from diagnosis. At last follow up, 7/33 (21.2%) patients were alive. Median overall survival was 13 months (0.07-70.6).Conclusion: BJI among HSCT recipients is infrequent. The most common infection is native joint septic arthritis. Pathogens appear similar to patients without HSCT. Treatment involving surgical-medical modalities is successful, with most patients surviving >1 year after BJI.

scholarly journals Epidemiology of complex bone and joint infections in France using a national registry: The CRIOAc network

2020 ◽  
Author(s):  
Adrien Lemaignen ◽  
Louis Bernard ◽  
Simon Marmor ◽  
Tristan Ferry ◽  
Leslie Grammatico-Guillon ◽  
...  
Keyword(s):  
National Registry ◽  
Joint Infections ◽  
Bone And Joint Infections

Systematic review and meta-analysis of antibiotic therapy for bone and joint infections

2001 ◽  
Vol 1 (3) ◽  
pp. 175-188 ◽  
Author(s):  
Dirk Stengel ◽  
Kai Bauwens ◽  
Jalid Sehouli ◽  
Axel Ekkernkamp ◽  
Franz Porzsolt
Keyword(s):  
Systematic Review ◽  
Antibiotic Therapy ◽  
Meta Analysis ◽  
Joint Infections ◽  
Bone And Joint Infections
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