scholarly journals Antioxidant Potential of Glycyrrhiza glabra L. roots: In-Vitro Evidences

2020 ◽  
Vol 8 (1) ◽  
pp. 9-13
Author(s):  
Varinder Singh ◽  
Amit Kumar
Keyword(s):  
Nitric Oxide ◽  
Glycyrrhiza Glabra ◽  
Inhibitory Effects ◽  
High Antioxidant Activity ◽  
Glycyrrhiza Glabra L ◽  
Strong Candidate ◽  
Dpph Scavenging ◽  
Antioxidant Effects ◽  
Reducing Potential

Background: The study was aimed to determine the mechanism of antioxidant effects of Glycyrrhiza glabra L. (GG) roots using in-vitro assays.Methods: The various extracts of GG roots were prepared and evaluated for DPPH scavenging, reducing effects and nitric oxide inhibiting activities. Prepared extracts were screened for the presence of various phytochemicals and quantified on the basis of phytochemical present therein.Results: The results showed that all the prepared extracts contained phenolic compounds. Also, extract showed appreciable antioxidant effects in all three assays employed. However, among prepared extracts, ethylacetate extract was found to have strong free radical inhibition, ferric reducing potential and nitric oxide inhibitory effects. The reason for high antioxidant activity in ethylacetate extract could be attributed to the significant amount phenol compounds present in it. Conclusion: Evidently, GG’s capacity to scavenge free radicals, reducing potential and inhibit nitric oxide contributes to its antioxidant effects and thus, could be a strong candidate for developing antioxidant based drug therapy.

Formulation and Evaluation of Polyherbal Cream Containing Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L and Azadirachta indica A. Juss. Extracts to Topical Use

2020 ◽  
Vol 25 (2) ◽  
pp. 61-71
Author(s):  
Rajendra Gyawali ◽  
Rupesh Kumar Gupta ◽  
Sahana Shrestha ◽  
Rajendra Joshi ◽  
Prem Narayan Paudel
Keyword(s):  
Azadirachta Indica ◽  
Antioxidant Properties ◽  
Flow Property ◽  
Antioxidant Property ◽  
Glycyrrhiza Glabra ◽  
Cinnamomum Zeylanicum ◽  
Cream Formulation ◽  
Glycyrrhiza Glabra L ◽  
Lipid Peroxidase ◽  
Dpph Scavenging

Alcoholic extracts of medicinal plants Cinnamomum zeylanicum Blume, Glycyrrhiza glabra L, and Azadirachta indica A. Juss were subjected to the evaluation of antioxidant properties and combined for the cream formulation. The antioxidant property was determined by using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay and inhibition of lipid peroxidase assays. The cream formulation was designed using Minitab software and a central composite design was used to study the effect of dependent variables, steric acid and cetyl alcohol on the response variables such as, viscosity, pH, and spreadability. The phytochemical screening of extracts showed the presence of tannin, phenol, flavonoids, saponins, and alkaloids. Antioxidant properties of the extracts and their relative composition were found variable. Composition F3 (C. zeylanicum Blume: G. glabra L: A. indica A. Juss; 01: 02: 01) possessed the highest antioxidant capacity compared to other ratios. The cream prepared from this composition was found stable for pH, viscosity as well as antioxidant activity under normal condition (25) and accelerated condition (40 ). The cream with DPPH scavenging activity of 93.86 % at 15 µg/mL (IC50 8.58±0.30) and lipid peroxidase assay 90.93 % at 200 µg/mL (IC50 72.30±0.60) with pH 5.50 was found with a non-Newtonian positive thixotropic flow property. Parameters like pH, viscosity, and spreadability of the cream were within the acceptance range, and found stable and permeable

Evaluating the in vitro antituberculosis, antibacterial and antioxidant potential of fungal endophytes isolated from Glycyrrhiza glabra L.

2016 ◽  
Vol 5 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Aiyatullah Shah ◽  
Muzafar Ahmad Rather ◽  
Aabid Manzoor Shah ◽  
Saleem Mushtaq ◽  
Aehtesham Hussain ◽  
...  
Keyword(s):  
Fungal Endophytes ◽  
Glycyrrhiza Glabra ◽  
Antioxidant Potential ◽  
Glycyrrhiza Glabra L

scholarly journals МИКРОРАЗМНОЖАВАНЕ IN VITRO НА GLYCYRRHIZA GLABRA L. (СЛАДЪК КОРЕИ) ДИРЕКТНО ПЪПКООБРАЗУВАНЕ ОТ НОДАЛНИ СТЪБЛЕНИ СЕГМЕНТИ

1992 ◽  
Vol 6 (1) ◽  
pp. 13-15
Author(s):  
Пенка Робева-Давидова ◽  
Веселка Гюлева ◽  
Атанас Атанасов ◽  
П. Робева-Давидова ◽  
В. Гюлева ◽  
...  
Keyword(s):  
Glycyrrhiza Glabra ◽  
Glycyrrhiza Glabra L

scholarly journals The Porphyromonas gingivalis inhibitory effects, antioxidant effects and the safety of a Sri Lankan traditional betel quid - an in vitro study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Madhavi Priyanka Paranagama ◽  
Nadisha Sewwandi Piyarathne ◽  
Tharanga Lakmali Nandasena ◽  
Sumedha Jayatilake ◽  
Ayanthi Navaratne ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
In Vitro Study ◽  
Vitro Study ◽  
Betel Quid ◽  
Sri Lankan ◽  
Inhibitory Effects ◽  
Antioxidant Effects

scholarly journals Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model

Data in Brief ◽  
2021 ◽  
pp. 107535
Author(s):  
Gayathree Karthikkeyan ◽  
Ashwini Prabhu ◽  
Ravishankar Pervaje ◽  
Sameera Krishna Pervaje ◽  
Prashant Kumar Modi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Glycyrrhiza Glabra ◽  
Glycyrrhiza Glabra L ◽  
Dose Dependent

scholarly journals Effects of silver nitrate (AgNO3) on growth and anatomical structure of vegetative organs of liquorice (Glycyrrhiza glabra L.) under in vitro condition

Plant Omics ◽  
2018 ◽  
pp. 153-160
Author(s):  
Farnaz Tahoori ◽  
Ahamd Majd ◽  
Taher Nejadsattari ◽  
Hamideh Ofoghi ◽  
Alireza Iranbakhsh
Keyword(s):  
In Vitro Culture ◽  
Silver Nitrate ◽  
Leaf Area ◽  
Cell Walls ◽  
Anatomical Structure ◽  
Glycyrrhiza Glabra ◽  
Vegetative Organs ◽  
Significant Difference ◽  
Glycyrrhiza Glabra L

Liquorice (Glycyrrhiza glabra L.) has been used worldwide as a medicine for a long time. In this research, the effect of silver nitrate (AgNO3) as a growth regulator and anti-ethylene in in vitro culture was investigated on growth and anatomical structure of vegetative organs (root, hypocotyl, shoot, leaf) as well as the number of stomata and trichomes in the leaves of liquorice under in vitro culture condition. The seeds were cultured in MS culture media containing different concentrations of AgNO3 (0, 2, 4, 8, and 10 mg L-1). Investigations on 20-day seedlings after three replications showed a significant increase in length and growth of roots, hypocotyls and shoots, and decreased number of stomata and trichomes in the samples treated with AgNO3 (P≤0.05). The effects of AgNO3 on anatomical structures of the organs included the increased cell division in root and shoot tips, reduced vascular tissues and sclerenchyma-fiber (with lignified cell walls), increased thickness of Casparian strip and cell walls of endodermis, reduced thickness of epidermis and increased intercellular spaces in mesophyll. The leaf area was measured in the 4-month plantlets, showing a significant increase in the samples treated with AgNO3. Furthermore, there was significant difference in increased leaf area applying 10 mg L-1 treatment and other concentrations as well as between the concentrations of 2 and 8 mg L-1. It seems that these results are due to the inhibitory effects of AgNO3 on the production and function of ethylene and the plant strategy to increase the tolerance against silver metal.

scholarly journals In vitro anti-Candida activity of Glycyrrhiza glabra L.

2016 ◽  
Vol 83 ◽  
pp. 81-85 ◽  
Author(s):  
Natália Martins ◽  
Isabel C.F.R. Ferreira ◽  
Mariana Henriques ◽  
Sónia Silva
Keyword(s):  
Glycyrrhiza Glabra ◽  
Glycyrrhiza Glabra L

scholarly journals Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Shih-Sheng Chang ◽  
Viola S. Y. Lee ◽  
Yu-Lun Tseng ◽  
Kuan-Cheng Chang ◽  
Kuen-Bao Chen ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Platelet Activation ◽  
Causes Of Death ◽  
Red Wine ◽  
Mechanistic Explanation ◽  
Major Constituent ◽  
Inhibitory Effects ◽  
Leukocyte Aggregation ◽  
Antioxidant Effects

Platelet activation and its interaction with leukocytes play an important role in atherothrombosis. Cardiovascular diseases resulted from atherothrombosis remain the major causes of death worldwide. Gallic acid, a major constituent of red wine and tea, has been believed to have properties of cardiovascular protection, which is likely to be related to its antioxidant effects. Nonetheless, there were few and inconsistent data regarding the effects of gallic acid on platelet function. Therefore, we designed thisin vitrostudy to determine whether gallic acid could inhibit platelet activation and the possible mechanisms. From our results, gallic acid could concentration-dependently inhibit platelet aggregation, P-selectin expression, and platelet-leukocyte aggregation. Gallic acid prevented the elevation of intracellular calcium and attenuated phosphorylation of PKCα/p38 MAPK and Akt/GSK3βon platelets stimulated by the stimulants ADP or U46619. This is the first mechanistic explanation for the inhibitory effects on platelets from gallic acid.

scholarly journals PRELIMINARY PHYTOCHEMICAL SCREENING AND IN-VITRO FREE RADICAL SCAVENGING ACTIVITY OF ROOT EXTRACTS OF GLYCYRRHIZA GLABRA L

2016 ◽  
Vol 9 (6) ◽  
pp. 85
Author(s):  
Archana Sakthi
Keyword(s):  
Nitric Oxide ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Glycyrrhiza Glabra ◽  
Peroxide Radical ◽  
Scavenging Activity ◽  
Root Extracts ◽  
Nitric Oxide Radical ◽  
Glycyrrhiza Glabra L

ABSTRACT:     Obesity is an international health problem caused by various environmental and genetic factors. Herbal supplements have proved to be active against obesity. Glycyrrhiza glabra belongs to the family of Fabaceae. Glycyrrhiza glabra was used traditionally to treat various diseases. Hence the current study was planned to investigate the phytochemicals and antioxidants present in Glycyrrhiza glabra. Materials and Methods: The preliminary qualitative, quantitative phytochemicals and antioxidants were investigated from the root extracts of Glycyrrhiza glabra. Results: The preliminary qualitative analysis of various extracts of Glycyrrhiza glabra showed the presence of Phenols, Flavonoids, Tannins, Saponins and Quinones. Quantitative analysis of Glycyrrhiza glabra showed elevated amounts of phenols, flavonoids and tannins in ethanolic extracts. The Aqueous, ethanol, hydro alcoholic extracts of Glycyrrhiza glabra showed 211±2.64, 281.66±1.57, 263±14.2 mg of phenols, 152.66±3.05, 187.33±1.52, 183.33±3.05 mg of flavonoids, 21.33±0.57, 41±3.46, 34.3±1.15 mg of Tannins, 42.33±2.05, 63.33±1.52, 36.33±1.57 mg of terpenoids. The antioxidant properties of the ethanolic extract of Glycyrrhiza glabra were evaluated with the 2,2-diphenyl-1-picryl hydrazyl (DPPH), Nitric Oxide radical (NO), Superoxide radical (SO), Hydrogen peroxide radical (H2O2), Hydroxyl radical (HO) Scavenging activity. The IC50 value of Glycyrrhiza glabra is 120 µg/ml for DPPH, 208 µg/ml for (NO), 196 µg/ml for (SO), 148 µg/ml for (H2O2), and 252 µg/ml for (OH). Invitro method suggests that Glycyrrhiza glabra is more powerful against nitric oxide and hydroxyl radicals. Conclusion: This preliminary study shows that Glycyrrhiza glabra is a promising herb with many phytochemicals and antioxidants it can be further investigated for its antiobesity potential.Key words: Glycyrrhiza glabra L., phytochemicals, antioxidant and obesity.

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