Proposals for the ISS: «Netcells» Experiment Influence of microgravity on growth, structure, and functions of nervous, endocrine and transformed cells

2000 ◽  
Vol 6 (4) ◽  
pp. 102-103
Author(s):  
P.G. Kostyuk
Keyword(s):  
Transformed Cells ◽  
Growth Structure ◽  
Structure And Functions

scholarly journals STRUCTURE AND FUNCTIONS OF MAIN APOPTOSIS RECEPTORS AND LIGANDS

2015 ◽  
Vol 14 (2) ◽  
pp. 23-30 ◽  
Author(s):  
V. A. Misyurin
Keyword(s):  
Cell Membrane ◽  
Fas Ligand ◽  
Transformed Cells ◽  
Biological Functions ◽  
Map Kinase Cascade ◽  
Kinase Cascade ◽  
External Signals ◽  
Structure And Functions ◽  
Apoptotic Signal Transduction ◽  
Apoptotic Signal

Apoptosis can be triggered from external signals. Several homologous receptors transmit apoptotic signals from outside into the cell. For successful activation of apoptosis receptors should interact with their ligands. For example, FAS receptor must bind with FAS-ligand, TNFR1 with TNFα, TRAIL-R1 and TRAIL-R2 with TRAIL, DR3 - with TL1A, respectively. In majority of cases ligands should be anchoring in the cell membrane to perform their functions. FAS and TNFR1 receptors trigger apoptosis only when they are internalized into the cell’s cytoplasm. If FAS and TNFR1 are not internalized, then anti-apoptotic program won’t start. In contrast, TRAIL-R1, TRAIL-R2 and DR3 aren’t internalized during apoptotic signal transduction. Other receptors, TNFR2, TRAIL-R3 and TRAIL-R4 start an anti-apoptotic program. The apoptotic signal starts when DISC complex is formed on the inner side of the cell membrane. FADD, procaspase-8 and intracellular domain of receptor form together DISC complex. If the DISC complex wasn’t formed, signal is transmitted by the NFкB-way via MAP-kinase cascade. In such conditions anti-apoptotic program starts. A variety of receptors and ligands provides for multiple biological functions. For example, receptor-mediated apoptosis takes a part in elimination of infected or transformed cells, regulation of inflammation, modulation of ontogenesis, hematopoiesis and antibody production.

Cell surface alteration in Epstein-Barr virus-transformed cells from patients with extreme insulin resistance

Diabetes ◽  
1990 ◽  
Vol 39 (8) ◽  
pp. 924-927 ◽  
Author(s):  
D. L. Gorden ◽  
A. Robert ◽  
V. Y. Moncada ◽  
S. I. Taylor ◽  
J. Muhlhauser ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Surface ◽  
Epstein Barr Virus ◽  
Transformed Cells ◽  
Barr Virus ◽  
Surface Alteration ◽  
Extreme Insulin Resistance ◽  
Epstein Barr

Relationship Among Tau Antigens Isolated from Various Lines of Simian Virus 40-Transformed Cells

1980 ◽  
Vol 34 (3) ◽  
pp. 650-657 ◽  
Author(s):  
Daniel T. Simmons ◽  
Malcolm A. Martin ◽  
Peter T. Mora ◽  
Chungming Chang
Keyword(s):  
Simian Virus 40 ◽  
Simian Virus ◽  
Transformed Cells

Subgenomic mRNA in OK10 Defective Leukemia Virus-Transformed Cells

1982 ◽  
Vol 42 (1) ◽  
pp. 71-82 ◽  
Author(s):  
S. Saule ◽  
A. Sergeant ◽  
G. Torpier ◽  
M. B. Raes ◽  
S. Pfeifer ◽  
...  
Keyword(s):  
Leukemia Virus ◽  
Transformed Cells
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