scholarly journals FULLERENE C[sub]60[/sub] INHIBITED FREE RADICAL AND DESTRUCTIVE PROCESSES IN CONNECTIVE TISSUE DURING ADJUVANT ARTHRITIS IN RATS

2015 ◽  
Vol 61 (2) ◽  
pp. 80-86 ◽  
Author(s):  
T. V. Mamontova T. V. Mamontova ◽  
◽  
L. E. Vesnina L. E. Vesnina ◽  
M. V. Mikityuk M. V. Mikityuk ◽  
N. A. Bobrova N. A. Bobrova ◽  
...  
Keyword(s):  
Free Radical ◽  
Connective Tissue ◽  
Adjuvant Arthritis ◽  
Destructive Processes

Fullerene C60 Inhibited Free-Radical and Destructive Processes in the Connective Tissue under Adjuvant Arthritis in Rats

2016 ◽  
Vol 7 (2) ◽  
pp. 119-126
Author(s):  
Tatyana V. Mamontova ◽  
Ludmila E. Vesnina ◽  
Marina V. Mikityuk ◽  
Nellya A. Bobrova ◽  
Larisa A. Kutsenko ◽  
...  
Keyword(s):  
Free Radical ◽  
Connective Tissue ◽  
Adjuvant Arthritis ◽  
Fullerene C60 ◽  
Destructive Processes

Glucomannan reduces neutrophil free radical production in vitro and in rats with adjuvant arthritis

2009 ◽  
Vol 59 (6) ◽  
pp. 399-403 ◽  
Author(s):  
Katarína Drábiková ◽  
Tomáš Perečko ◽  
Radomír Nosáľ ◽  
Katarína Bauerová ◽  
Silvester Poništ ◽  
...  
Keyword(s):  
Free Radical ◽  
Adjuvant Arthritis ◽  
Free Radical Production ◽  
Radical Production

Influence of adjuvant arthritis on connective-tissue metabolism

1976 ◽  
Vol 6 (5) ◽  
pp. 651-656 ◽  
Author(s):  
B. Exer ◽  
P. Krupp ◽  
R. Menassé ◽  
L. Riesterer
Keyword(s):  
Connective Tissue ◽  
Adjuvant Arthritis ◽  
Tissue Metabolism ◽  
Connective Tissue Metabolism

scholarly journals THE ROLE OF DISORGANIZATION OF CONNECTIVE TISSUE AND BASEMENT MEMBRANE OF RENAL TUBULAR EPITHELIUM IN THE PATHOGENESIS OF UROLITHIASIS

2020 ◽  
Vol 28 (2) ◽  
pp. 78-81
Author(s):  
Vadim A. Zubarev ◽  
Juliya M. Zabrodskaya ◽  
Anatoly I. Arkhangel'sky ◽  
Marlen E. Topuzov ◽  
Iliya V. Dovzhansky
Keyword(s):  
Connective Tissue ◽  
Basement Membrane ◽  
Stone Formation ◽  
Renal Tissue ◽  
The State ◽  
Renal Tubules ◽  
Renal Tubular Epithelium ◽  
Destructive Processes ◽  
Different Levels

According to a number of researchers, pathological changes in the structures of the renal papilla play a key role in the pathogenesis of urolithiasis. According to the results of existing studies, destructive processes in collagen are characterized by a change in the length, thickness of the fibers and their orientation in space. Collagen disorganization has enzymatic and non-enzymatic mechanisms. The aim of the study was to study the frequency and features of localization of Randall's plaques and morphological study of the state of connective tissue and the basement membrane of the epithelium of the renal tubules of different levels in urolithiasis. Microscopically studied preparations of 29 biopsies of renal tissue obtained from patients with fibro-uretero-pyeloscopy (11), percutaneous nephrolitholapaxy (18) and preparations obtained at 20 autopsies in cases without visible renal pathology. Histological preparations were stained with hematoxylin and eosin to determine the state of connective tissue fibers using Van Gieson, Mallory, Schiff-reagent, alcian blue, and Kos for calcifications. The results of the study show that the morphological signs of mucoid swelling of the connective tissue and basement membrane of the epithelium of the renal tubules of different levels in combination with the formation of microcalcifications require further study of the possible role of disorganization of the connective tissue of the renal stroma in the initiation of stone formation in the kidneys.

Enhanced intraarticular free radical reactions in adjuvant arthritis rats

2006 ◽  
Vol 40 (5) ◽  
pp. 455-460 ◽  
Author(s):  
Ken-Ichi Yamada ◽  
Toshitaka Nakamura ◽  
Hideo Utsumi
Keyword(s):  
Free Radical ◽  
Adjuvant Arthritis ◽  
Radical Reactions ◽  
Free Radical Reactions

scholarly journals Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Audrey Dooley ◽  
K. Richard Bruckdorfer ◽  
David J. Abraham
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Systemic Sclerosis ◽  
Free Radical ◽  
Animal Models ◽  
Connective Tissue ◽  
Vascular Dysfunction ◽  
Oxidant Stress ◽  
Unknown Aetiology ◽  
Protective System

Systemic sclerosis (scleroderma: SSc) is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ultimately internal organ failure, and death. One of the most important and early modulators of disease activity is thought to be oxidative stress. Evidence suggests that the free radical nitric oxide (NO), a key mediator of oxidative stress, can profoundly influence the early microvasculopathy, and possibly the ensuing fibrogenic response. Animal models and human studies have also identified dietary antioxidants, such as epigallocatechin-3-gallate (EGCG), to function as a protective system against oxidative stress and fibrosis. Hence, targeting EGCG may prove a possible candidate for therapeutic treatment aimed at reducing both oxidant stress and the fibrotic effects associated with SSc.

scholarly journals Metabolic profile and content of the connective tissues’ biopolymers in the blood serum of service boars at the different regime of reproductive loading

2019 ◽  
Vol 21 (93) ◽  
pp. 21-26
Author(s):  
O. P. Timoshenko ◽  
G. V. Vikulina ◽  
D. V. Kibkalo ◽  
I. G. Moraru
Keyword(s):  
Physical Activity ◽  
Connective Tissue ◽  
Blood Serum ◽  
Muscle Tissue ◽  
Creatine Phosphokinase ◽  
Biochemical Tests ◽  
Group I ◽  
Inflammatory Processes ◽  
Total Creatine ◽  
Destructive Processes

It is necessary to carry out not only the evaluation of sexual activity of breeder boars and the quality of their sperm, but carefully investigate the metabolic status by laboratory methods during the medical examination. It helps to determine the optimal parameters for the implementation of the reproductive potential of the breeder boars. Biochemical methods of research can establish imbalance in metabolism, the nature and localization of cytolytic processes by the degree of enzymes activity in serum. However, in order to detect inflammatory or destructive changes in the connective tissue structures, in particular the musculoskeletal system, the most informative indexes will be biopolymers of the connective tissue – glycoproteins and proteoglycans. The results of a complex examination of clinically healthy breeder boars with different regime of their production use, which includes an extended set of biochemical tests with the determination of glycoprotein, chondroitin sulfate, total glycosaminoglycans and their fractions, are presented in this paper. It was found that the level of such parameters as the total protein and its fractions, urea, aspartate and alanine aminotransferase activity, and the MB fraction of creatine phosphokinase did not have any significant differences. For breeder boars that were used in reproductive events irregularly (group I), there was an indicative higher level of creatinine and glycosaminoglycans. In animals with regular use as the herd (group II), the level of creatinine and fractions of glycosaminoglycans (GAG) was lower, but there was an increasing in cholesterol, β-lipoproteins, and activity of total creatine phosphokinase. The probable difference in these indicators can be explained by the difference in the intensity of the energy metabolism processes in muscle tissue. Indeed, during long-term hard work of skeletal muscles, not only glycogen stores are used, but also the use of lipids is of great importance. In addition, the raising of cholesterol and β-lipoproteins may be due to their active involvement in the synthesis of steroid hormones. Increasing the activity of total creatine phosphokinase in blood serum of animals with the intensive use in technology probably is the evidence of severe physical activity and the development of destructive processes in muscle tissue (hyperenzymemia is detected in early stages of myopathy). The absence of the most inflammatory processes was evidenced by the unchanged level of serum glycoproteins, which are known as the acute phase tests. Differences in the parameters of the state of connective tissue were determined at the levels of general GAG, their I and III fractions (chondroitin-6-sulfate and heparan sulfate, respectively). In the first group of boars, there was a higher level of I fraction of GAG, that indicated a significant load on the joints' cartilages and the gradual development of destructive processes in them. About the III fraction of GAG, an increasing of their blood content could indicate the reaction of the vascular flow, changes in ventilation of the lungs, the course of anti-inflammatory processes in animals with the appearance of intense physical activity.

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