scholarly journals One Step at a Time, Stem Cell Therapy for Traumatic Brain Injury Needs Two More Breakthroughs

2016 ◽  
Vol 1 (4) ◽  
Author(s):  
Gajavelli Shyam
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Brain Injury ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
One Step

scholarly journals The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges

BioMedica ◽  
2021 ◽  
Vol 37 (3) ◽  
pp. 1-19
Author(s):  
Cui Lianxu ◽  
Yasmeen Saeed ◽  
Li Haomin ◽  
Yang Jingli
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Brain Injury ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Basic Research ◽  
Treatment Modalities ◽  
Mesenchymal Stem Cell Therapy

<p>Traumatic brain injury (TBI) is a focal injury with limited reliable treatment options. Despite the large volume of basic research into TBI (particularly on the complex pathophysiology and on the application of various techniques), the treatment of TBI currently remains a challenge due to the low efficacy of available therapeutic options. Recent studies have shown that stem cells possess the ability to aid in recovery from the damaging effects of the craniocerebral injury. Herein, we attempted to present a generalized critique for the role of mesenchymal stem cell therapy in TBI, its underlying mechanisms, and the scope for improvements in TBI treatment identified through preclinical studies, clinical studies, and other research in the light of previously reported literature. Finally, we summarized some novel strategies to overcome the clinical challenges in TBI recovery. Collectively, the major objective of this review is to highlight the to-date available findings regarding role of stem cell therapy in TBI and pave the way for the development of safe and efficient regenerative treatment modalities for TBI by comprehensive understanding the specific mechanism.</p>

scholarly journals Điều trị chấn thương sọ não cấp tính bằng ghép tế bào gốc tự thân tại Bệnh viện Trung ương Huế

2020 ◽  
Author(s):  
Duy Thăng Nguyễn
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Brain Injury ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mononuclear Cells ◽  
Control Group ◽  
Acute Traumatic Brain Injury

TREATING ACUTE TRAUMATIC BRAIN INJURY BY USING AUTOLOGOUS BONE MARROW DERIVED STEM CELLS AT HUE CENTRAL HOSPITAL The number of acute traumatic injuries caused by accidents has been increasing in recent years, leading to death or serious complications in cognitive behavior or social function. Few pre-clinical studies around the world have shown the ablity of stem cells in neuroprotection. Therefore, we apply autologous stem cells transplants in two acute traumatic brain injury patients to evaluate the effectiveness of stem cell therapy. Method: Three male patients aged 23 and 49 years with a postresuscitation Glasgow Coma Scale of 6 and 8 were treated with autologous mononuclear cells delivered intravenously within 2-3 hours after bone marrow harvesting, mesenchymal stem cells were isolated and expanded in culture before the system administrating through vein after 7-10 days. To determine the safety of the procedure, systemic and cerebral hemodynamics were monitored during bone marrow harvest; infusion-related toxicity was determined by hepatic enzymes, and renal function. Result and conclusion: There were no significant changes in liver, kidney and hematological criteria. BI and Glasgow indexes increased significantly compared to the control group. There was no abnormal complication within 4-6 weeks after cell transplantation. Autologous stem cell therapy is safe and effective for patients with acute brain injury. Keywords: Stem cells; Mesenchymal stem cell; Bone marrow; Acute traumatic brain injury

scholarly journals Utilizing pharmacotherapy and mesenchymal stem cell therapy to reduce inflammation following traumatic brain injury

2016 ◽  
Vol 11 (9) ◽  
pp. 1379 ◽  
Author(s):  
CesarV Borlongan ◽  
Sherwin Mashkouri ◽  
MarciG Crowley ◽  
MichaelG Liska ◽  
Sydney Corey
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Brain Injury ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy
Sign in / Sign up

Export Citation Format

Share Document