scholarly journals The scientific validity of schedule of controlled substances

2018 ◽  
Vol 9 (4) ◽  
Author(s):  
Salerian Alen J
Keyword(s):  
Scientific Validity ◽  
Controlled Substances

Contemporary architectural production in the Alpine area through the lens of regionality

ARCHALP ◽  
2018 ◽  
pp. 11-13
Author(s):  
Antonio De Rossi ◽  
Roberto Dini ◽  
Stefano Girodo
Keyword(s):  
State Of The Art ◽  
Central Core ◽  
Scientific Committee ◽  
Wide Angle ◽  
Scientific Validity ◽  
Architectural Production ◽  
Alpine Regions ◽  
Alpine Area ◽  
Building Culture ◽  
Alpine Space

Given that this is the inaugural edition, we thought that the first issue of the international journal «ArchAlp» needed to be characterized by a wide angle view, taking shape as sort of veritable tour d’horizon of the alpine space. Thinking with the scientific committee of the journal, it seemed to us that a reflection on the characteristics of contemporary architectural production in the European Alpine area, starting from regionally-based analyses and interpretations, could be very important. A description of the state of the art, which in order to have scientific validity must be based on comparative interpretations, has the aim of restoring continuity and differences in the “building culture” among the various Alpine regions. From here the idea of building the central core around a series of local monographs.

Role of Phytochemicals in the Treatment of Breast Cancer: Natural Swords battling Cancer Cells

2021 ◽  
Vol 16 ◽  
Author(s):  
Rajni Sawanny ◽  
Sheersha Pramanik ◽  
Unnati Agarwal
Keyword(s):  
Breast Cancer ◽  
Molecular Mechanisms ◽  
Low Cost ◽  
Epigallocatechin Gallate ◽  
Cancer Therapeutics ◽  
Treatment Modalities ◽  
Breast Cancer Patients ◽  
Scientific Validity ◽  
Phytochemical Study ◽  
Treat Breast Cancer

: Breast cancer is the most common type of malignancy among ladies (around 30% of newly diagnosed patients every year). To date, various modern treatment modalities for breast cancer, such as radiotherapy, surgical method, hormonal therapy, and chemotherapeutic drug utilisation, are available. However, adverse drug reactions, therapeutic resistance, metastasis, or cancer reoccurrence chances remain the primary causes of mortality for breast cancer patients. To overcome all the potential drawbacks, we need to investigate novel techniques and strategies previously not considered and treat breast cancer effectively with safety and efficacy. For centuries, we utilise phytochemicals to treat various diseases because of their safety, low-cost & least or no side effects. Recently, naturally produced phytochemicals gain immense attention as potential breast cancer therapeutics because of their ideal characteristics; for instance, they operate via modulating molecular pathways associated with cancer growth and progression. The primary mechanism involves inhibition of cell proliferation, angiogenesis, migration, invasion, increasing anti-oxidant status, initiation of the arrest of the cell cycle, and apoptosis. Remedial viability gets effectively enhanced when phytochemicals work as adjuvants with chemotherapeutic drugs. This comprehensive review revolves around the latest chemopreventive, chemotherapeutic, and chemoprotective treatments with their molecular mechanisms to treat breast cancer by utilising phytochemicals such as vinca alkaloids, resveratrol, curcumin, paclitaxel, silibinin, quercetin, genistein and epigallocatechin gallate. The authors wish to extend the field of phytochemical study for its scientific validity and its druggability.

scholarly journals A biomimetic engineered bone platform for advanced testing of prosthetic implants

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Martina Sladkova-Faure ◽  
Michael Pujari-Palmer ◽  
Caroline Öhman-Mägi ◽  
Alejandro López ◽  
Hanbin Wang ◽  
...  
Keyword(s):  
Calcium Deposition ◽  
Animal Testing ◽  
Scientific Validity ◽  
Matrix Deposition ◽  
Prosthetic Implants ◽  
Gene Expression Matrix ◽  
Biomimetic Scaffolds ◽  
Resolution Imaging ◽  
Preclinical And Clinical Studies

AbstractExisting methods for testing prosthetic implants suffer from critical limitations, creating an urgent need for new strategies that facilitate research and development of implants with enhanced osseointegration potential. Herein, we describe a novel, biomimetic, human bone platform for advanced testing of implants in vitro, and demonstrate the scientific validity and predictive value of this approach using an assortment of complementary evaluation methods. We anchored titanium (Ti) and stainless steel (SS) implants into biomimetic scaffolds, seeded with human induced mesenchymal stem cells, to recapitulate the osseointegration process in vitro. We show distinct patterns of gene expression, matrix deposition, and mineralization in response to the two materials, with Ti implants ultimately resulting in stronger integration strength, as seen in other preclinical and clinical studies. Interestingly, RNAseq analysis reveals that the TGF-beta and the FGF2 pathways are overexpressed in response to Ti implants, while the Wnt, BMP, and IGF pathways are overexpressed in response to SS implants. High-resolution imaging shows significantly increased tissue mineralization and calcium deposition at the tissue-implant interface in response to Ti implants, contributing to a twofold increase in pullout strength compared to SS implants. Our technology creates unprecedented research opportunities towards the design of implants and biomaterials that can be personalized, and exhibit enhanced osseointegration potential, with reduced need for animal testing.

Research Ethics Committees’ Oversight of Biomedical Research in South Africa: A Thematic Analysis of Ethical Issues Raised During Ethics Review of Non-Expedited Protocols

2019 ◽  
Vol 14 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Blessing Silaigwana ◽  
Douglas Wassenaar
Keyword(s):  
South Africa ◽  
Research Ethics ◽  
South African ◽  
Biomedical Research ◽  
Ethical Issues ◽  
Ethics Committees ◽  
Financial Contracts ◽  
Scientific Validity ◽  
Participant Selection ◽  
Education And Awareness

In South Africa, biomedical research cannot commence until it has been reviewed and approved by a local research ethics committee (REC). There remains a dearth of empirical data on the nature and frequency of ethical issues raised by such committees. This study sought to identify ethical concerns typically raised by two South African RECs. Meeting minutes for 180 protocols reviewed between 2009 and 2014 were coded and analyzed using a preexisting framework. Results showed that the most frequent queries involved informed consent, respect for participants, and scientific validity. Interestingly, administrative issues (non-ethical) such as missing researchers’ CVs and financial contracts emerged more frequently than ethical questions such as favorable risk/benefit ratio and fair participant selection. Although not generalizable to all RECs, our data provide insights into two South African RECs’ review concerns. More education and awareness of the actual ethical issues typically raised by such committees might help improve review outcomes and relationships between researchers and RECs.

Philosophers and Physicians on the Scientific Validity of Latin Physiognomy, 1200-1500

2007 ◽  
Vol 12 (3) ◽  
pp. 285-312 ◽  
Author(s):  
Joseph Ziegler
Keyword(s):  
Early Modern ◽  
Middle Ages ◽  
Theoretical Basis ◽  
Scientific Validity ◽  
Body Of Knowledge ◽  
Rational Explanation ◽  
The Status ◽  
Jean Buridan ◽  
Natural Philosophers ◽  
Sound Theoretical Basis

AbstractThe article surveys and contextualizes the main arguments among philosophers and academic physicians surrounding the status of physiognomy as a valid science from the thirteenth to the early sixteenth centuries. It suggests that despite constant doubts, learned Latin physiognomy in the later Middle Ages was recognized by natural philosophers (William of Spain, Jean Buridan, William of Mirica) and academic physicians (Rolandus Scriptor, Michele Savonarola, Bartolomeo della Rocca [Cocles]) as a body of knowledge rooted in a sound theoretical basis. Physiognomy was characterized by stability and certainty. As a demonstrative science it was expected to provide rational explanation for every bodily sign. In this respect, learned physiognomy in the Middle Ages was dramatically different from its classical sources, from Islamic and possibly from early-modern physiognomy as well.

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