scholarly journals The Impact of Quantitative Parameters of Folliculogenesis in Controlled Ovarian Stimulation on IVF

2017 ◽  
Vol 3 (3) ◽  
Author(s):  
Tatiana Bocharova
Keyword(s):  
Ovarian Stimulation ◽  
Controlled Ovarian Stimulation ◽  
Quantitative Parameters ◽  
The Impact

The impact of quantitative parameters of folliculogenesis in controlled ovarian stimulation on IVF

2017 ◽  
Vol 23 (3) ◽  
pp. 55
Author(s):  
К. V. Krasnopol’skaya ◽  
T. A. Nazarenko ◽  
V. M. Zdanovskiy ◽  
O. A. Ankina ◽  
T. V. Bocharova
Keyword(s):  
Ovarian Stimulation ◽  
Controlled Ovarian Stimulation ◽  
Quantitative Parameters ◽  
The Impact

scholarly journals The Impact of Endometriosis on Controlled Ovarian Stimulation Outcome

2021 ◽  
Author(s):  
Dragoș Albu ◽  
Alice Albu
Keyword(s):  
In Vitro Fertilization ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Predictive Value ◽  
Reproductive Age ◽  
Important Predictor ◽  
Controlled Ovarian Stimulation ◽  
Vitro Fertilization ◽  
The Impact

Endometriosis, a frequent condition in reproductive age women, is also associated with infertility by mechanisms incompletely clarified. The effectiveness of endometriosis treatment for infertility is debated, being possible that in vitro fertilization (IVF) offers a better alternative. The response to controlled ovarian stimulation (COS) is an important predictor of live birth, but it might be affected in endometriosis possibly through a decrease of ovarian reserve. Moreover, the predictive value of anti-mullerian hormone (AMH) for the response to COS could be altered by factors disrupting the AMH production in endometriosis. Therefore, we aim to review the literature regarding the response to COS and the AMH production and their predictive value for COS response in patients with endometriosis.

scholarly journals The Impact of Controlled Ovarian Stimulation Hormones on the Metabolic State and Endocannabinoid System of Human Cumulus Cells

2020 ◽  
Vol 21 (19) ◽  
pp. 7124
Author(s):  
Valentina Notarstefano ◽  
Giorgia Gioacchini ◽  
Elisabetta Giorgini ◽  
Nina Montik ◽  
Andrea Ciavattini ◽  
...  
Keyword(s):  
Ovarian Stimulation ◽  
Endocannabinoid System ◽  
Cumulus Cells ◽  
Controlled Ovarian Stimulation ◽  
Human Menopausal Gonadotropin ◽  
Infrared Microspectroscopy ◽  
Expression Of Genes ◽  
Fourier Transform Infrared Microspectroscopy ◽  
System Metabolism ◽  
The Impact

Different Follicle Stimulating Hormone (FSH) formulation and Luteinizing Hormone (LH) are used in Assisted Reproductive Technology (ART) to induce follicles development and oocytes maturation, but it is still under debate which protocol is to be preferred. In the present study, the different effects on cumulus cells (CCs) of three controlled ovarian stimulation (COS) protocols, based on urinary FSH, recombinant FSH, or human Menopausal Gonadotropin (hMG) administration, were assessed. CCs were obtained from 42 normal-responders women undergoing COS, randomly divided into three groups according to the used gonadotropin formulation. Differences were found in the expression of genes belonging to the endocannabinoid system (the receptors CNR1, CNR2 and TRPV1, and the enzymes involved in the metabolisms of anandamide, NAPE-PLD and FAAH, and 2-acylglycerol, DAGL and MAGL); consistently, changes in lipid (PPARα, and FASN) and carbohydrate (GLUT1 and GLUT9) metabolisms, in CCs’ macromolecules composition (highlighted by Fourier Transform Infrared Microspectroscopy, FTIRM), and in the number of retrieved oocytes were found. For the first time, statistically significant evidence on the differences related to each COS protocol on the endocannabinoid system, metabolism and macromolecular composition of CCs was found, representing a proof of concept to be further confirmed in a larger cohort of patients.

scholarly journals Influence of controlled ovarian stimulation protocols on ovarian hyperstimulation syndrome patterns during in vitro fertilization programs

2019 ◽  
Vol 16 (4) ◽  
pp. 443-453
Author(s):  
S. V. Zhukovskaya ◽  
L. F. Mozhejko
Keyword(s):  
Embryo Transfer ◽  
Ovarian Stimulation ◽  
Ovarian Hyperstimulation Syndrome ◽  
Controlled Ovarian Stimulation ◽  
Ovarian Hyperstimulation ◽  
Gnrh Agonists ◽  
Early Form ◽  
The Impact ◽  
Group 1

Different protocols of controlled ovarian stimulation have a significant influence on ovarian hyperstimulation syndrome (OHSS) patterns in women who undergo in vitro fertilization programs (IVF).The objective of this research was to evaluate the impact of different ovarian stimulation protocols on various clinical and laboratory parameters of OHSS, such as embryologic characteristics, hormonal changes, hemostasis, and IVF outcomes. The study was made on the basis of the MPUE “Center of Reproductive Medicine” (Minsk, Belarus) and included,in total, 718 women who underwent IVF for infertility treatment. 103 patients developed OHSS and were divided into two groups based on hormonal stimulation protocols: Group 1 included 60 women who were stimulated with gonadotrophin releasing hormone (GnRH) agonists protocol; Group 2 consisted of 43 women who were prescribed GnRH antagonists during ovarian stimulation.In Group 1 (ovarian stimulation protocol with GnRH agonists), we established significantly higher serum concentrations of estradiol and progesterone during IVF and more marked hemostatic shift towards hypercoagulation: statistically significant elevation of fibrinogen and D-dimes simultaneously with decrease in the primary anticoagulants (antithrombin III and protein С) functional activity. Also, Group 1 had a significantly higher incidence of the early form of OHSS and embryo transfer cancellation caused by a high risk of severe OHSS.OHSS that has developed after the GnRH agonists protocol of controlled ovarian stimulation is associated with higher risks of complications and lower chances of successful pregnancy, which is explained by hyperestrogenic state, elevated progesterone levels, marked hypercoagulation, and higher incidence of early OHSS, which leads to the necessity of embryo transfer cancellation.

P–688 Assessment of ovarian vascularity by three-dimensional vaginal power Doppler on day two of menstrual cycle to predict the number of mature eggs collected

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
C Fakih ◽  
G Raad ◽  
R Azaki ◽  
R Yazbeck ◽  
R Zahwe ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Stimulation ◽  
Power Doppler ◽  
Ovarian Response ◽  
Controlled Ovarian Stimulation ◽  
Flow Index ◽  
Ovarian Volume ◽  
3 Dimensional ◽  
The Impact ◽  
Cycle Cancellation

Abstract Study question Could ovarian vascularity indices, measured by 3-dimensional (3D) vaginal power Doppler, predict the number of mature oocytes collected after controlled ovarian stimulation? Summary answer Ovarian vascularity index (VI) may be an indicator of poor (<three mature eggs collected) and high (>ten mature eggs collected) ovarian responses to gonadotropins. What is known already Poor and/or hyper ovarian responses to gonadotropins may be related to cycle cancellation during controlled ovarian stimulation (COS). In this context, gonadotropin dose is often individualized using patient features that predict ovarian response (such as age, antral follicular count (AFC) and anti-Müllerian hormone (AMH)). In parallel, ovarian vascularity color doppler is a valuable evaluation method to predict the ovarian hyperstimulation syndrome and the growth/maturity of Graafian follicles. The aim of the present study is to estimate the utility of 3-dimensional vaginal power Doppler and ovarian vascular flow indices in the prediction of the number of mature occytes collected after COS. Study design, size, duration A prospective study was conducted on 200 couples undergoing intracytoplasmic sperm injection cycle at Al Hadi Laboratory and Medical center, Beirut, Lebanon. It was performed between January 2020 and July 2020. Couples were categorized into poor responders group (3 or less metaphase II (MII) eggs collected) (n = 43), high responders group (10 or more MII eggs collected) group (n = 66), and normal responders group (more than 3 and less than 10 MII eggs collected) (n = 66). Participants/materials, setting, methods On the second day of the menstrual cycle, ovarian volume and vascularity parameters (vascularity index (VI), flow index (FI), and vascularity flow index (VFI)) were measured using the 3D power Doppler and the Virtual Organ Computer-Aided Analysis. On the same day, the antral follicle count was evaluated and a blood sample for AMH testing was collected. Women included in the study have undergone COS using GnRH antagonist protocol. Main results and the role of chance Receiver operator characteristics (ROC) curve model was used to predict the number of mature eggs collected. 7 parameters were used to predict poor and high ovarian responses (Age, AMH, AFC, ovarian volume, VI, FI and VFI). Ovarian VI significantly predicted poor ovarian response to gonadotropins (p = 0.033 and area under the curve (AUC)=0.668). Subsequently, the cut off value was 0.0025 with 84% sensitivity and 83.3% specificity. In parallel, ovarian VI significantly predicted high ovarian response to gonadotropins (p = 0.036 and AUC (0.778)) with a cut off value 0.0375 and with 77.8% sensitivity and 78.3% specificity. Furthermore, VFI significantly predicted high ovarian response to gonadotropins (p = 0.045; AUC=0.677). Limitations, reasons for caution It will be necessary to perform a prospective analysis on a broad sample size to validate these findings. In addition, it will be interesting to assess the impact of ovarian vascularity on pregnancy outcomes. Wider implications of the findings: Assessing ovarian vascularity prior to ovarian stimulation can help reduce the rate of cycle cancellation. In addition, more studies are welcomed in the field to unravel the mechanisms behind altered ovarian vascularity and to test the possibility of restoring normal ovarian physiology. Trial registration number Not applicable

Ovulation influences bone metabolism in women undergoing controlled ovarian stimulation

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
V Seifert-Klauss ◽  
AC Ritzinger ◽  
B Lesoine ◽  
M Kiechle ◽  
M Schmidmayr ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Ovarian Stimulation ◽  
Controlled Ovarian Stimulation
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