scholarly journals The Dose‐Response Relationship between Pulmonary Function Injury and Cumulative Dose of Tobacco Dust Exposure among Tobacco Processing Workers

2009 ◽  
Vol 51 (2) ◽  
pp. 164-168 ◽  
Author(s):  
Yongxing Zhang ◽  
Juan Wang ◽  
Jiezhi Lou
Keyword(s):  
Pulmonary Function ◽  
Cumulative Dose ◽  
Dose Response ◽  
Dust Exposure ◽  
Response Relationship ◽  
Dose Response Relationship

THE CUMULATIVE DOSE-RESPONSE RELATIONSHIP OF PIPECURONIUM BROMIDE (ARDUAN®) IN INFANTS AND CHILDREN

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A778
Author(s):  
J. B. Sarner ◽  
B. W. Brandom ◽  
M. L. Dong ◽  
D. Pickle ◽  
M. Weinberger ◽  
...  
Keyword(s):  
Cumulative Dose ◽  
Dose Response ◽  
Infants And Children ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Relationship Of ◽  
In Infants And Children

scholarly journals Pulmonary Function in Jute Dust‐Exposed Workers: A Dose‐Response Relationship

1997 ◽  
Vol 39 (4) ◽  
pp. 313-318 ◽  
Author(s):  
Jie Chen ◽  
Jiezhi Lou ◽  
Xiaofang Guo ◽  
Chen Zhou
Keyword(s):  
Pulmonary Function ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Exposed Workers

Western red cedar dust exposure and lung function: a dose-response relationship.

1996 ◽  
Vol 154 (4) ◽  
pp. 968-973 ◽  
Author(s):  
H K Noertjojo ◽  
H Dimich-Ward ◽  
S Peelen ◽  
M Dittrick ◽  
S M Kennedy ◽  
...  
Keyword(s):  
Lung Function ◽  
Dose Response ◽  
Dust Exposure ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Red Cedar ◽  
Western Red Cedar

Retreatment of trigeminal neuralgia with Gamma Knife radiosurgery: is there an appropriate cumulative dose?

2009 ◽  
Vol 111 (2) ◽  
pp. 359-364 ◽  
Author(s):  
Tomas Dvorak ◽  
Arkadiy Finn ◽  
Lori Lyn Price ◽  
John E. Mignano ◽  
Markus M. Fitzek ◽  
...  
Keyword(s):  
Trigeminal Neuralgia ◽  
Gamma Knife ◽  
Trigeminal Nerve ◽  
Cumulative Dose ◽  
Dose Response ◽  
Pain Control ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Excellent Outcome ◽  
Number Of Patients

Object Trigeminal neuralgia (TN) is a disorder of the trigeminal nerve that results in intense episodic pain. Primary treatment with Gamma Knife surgery (GKS) is well established; however, a significant number of patients experience recurrence of TN over time. Repeat GKS can be performed, but the retreatment dose has not been well established. In this study, the authors present their institutional retreatment results and compare them with other series. Methods Between December 2003 and January 2006, 28 patients were treated at Tufts Medical Center with repeat GKS for recurrence of TN. All patients had been initially treated with GKS at this institution, and only those with significant pain improvement were offered retreatment. The maximum dose was prescribed using a single isocenter; the 4-mm collimator was used. The initial median GKS dose was 80 Gy, the median retreatment dose was 45 Gy, and the median cumulative dose was 125 Gy. The median time between GKS procedures was 18.1 months. Facial pain outcomes were defined using the Marseille scale. Excellent outcome was defined as no pain (with or without medications), and good outcome was defined as > 50% pain relief. Toxicity was categorized as none, mild, or bothersome. The median clinical follow-up after the second GKS was 19.7 months. Our clinical outcomes were compared with 8 previously reported retreatment series (including 1 abstract), both for rate of pain control and for rate of complications. Results Outcomes after the second GKS were excellent in 29% (8 patients), good in 32% (9), and poor in 39% (11). Four patients (14%) experienced no improvement after repeat GKS. Eight patients (29%) experienced new trigeminal nerve dysfunction, including numbness (11%), paresthesia (14%), dysesthesia (4%), taste alteration (11%), and bite weakness (4%). None of these were bothersome. No patient developed corneal numbness. Univariate analysis failed to reveal any significant predictors of pain control or complications. Seven published peer-reviewed retreatment series and the authors' data (total 215 patients) were analyzed. There was a cumulative dose-response relationship for both pain control (p = 0.04) and new trigeminal dysfunction (p = 0.08). Successful pain control was strongly correlated with development of new dysfunction (p = 0.02). A cumulative dose > 130 Gy was more likely to result in successful (> 50%) pain control, but was also more likely (> 20%) to result in development of new dysfunction. Conclusions Successful retreatment of patients in whom the initial GKS treatment fails is feasible. Patients who respond initially may be at a higher risk of retreatment-related complications. There appears to be a dose-response relationship for both pain control and development of new side effects. It is important to counsel and treat patients individually based on this dose-response relationship.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

Sign in / Sign up

Export Citation Format

Share Document