scholarly journals Stability of a mathematical model of tumour-induced angiogenesis

2016 ◽  
Vol 21 (3) ◽  
pp. 325-344
Author(s):  
Dan Li ◽  
Wanbiao Ma ◽  
Songbai Guo

A model consisting of three differential equations to simulate the interactions between cancer cells, the angiogenic factors and endothelial progenitor cells in tumor growth is developed. Firstly, the global existence, nonnegativity and boundedness of the solutions are discussed. Secondly, by analyzing the corresponding characteristic equations, the local stability of three boundary equilibria and the angiogenesis equilibrium of the model is discussed, respectively. We further consider global asymptotic stability of the boundary equilibria and the angiogenesis equilibrium by using the well-known Liapunov–LaSalle invariance principal. Finally, some numerical simulations are given to support the theoretical results.

Author(s):  
Rachida Mezhoud ◽  
Khaled Saoudi ◽  
Abderrahmane Zaraï ◽  
Salem Abdelmalek

AbstractFractional calculus has been shown to improve the dynamics of differential system models and provide a better understanding of their dynamics. This paper considers the time–fractional version of the Degn–Harrison reaction–diffusion model. Sufficient conditions are established for the local and global asymptotic stability of the model by means of invariant rectangles, the fundamental stability theory of fractional systems, the linearization method, and the direct Lyapunov method. Numerical simulation results are used to illustrate the theoretical results.


Author(s):  
Jiandong Zhao ◽  
Tonghua Zhang ◽  
Zhixia Han

AbstractTo study the effect of environmental noise on the spread of the disease, a stochastic Susceptible, Infective, Removed and Susceptible (SIRS) model with two viruses is introduced in this paper. Sufficient conditions for global existence of positive solution and stochastically asymptotic stability of disease-free equilibrium in the model are given. Then, it is shown that the positive solution is stochastically ultimately bounded and the moment average in time of the positive solution is bounded. Our results mean that the environmental noise suppresses the growth rate of the individuals and drives the disease to extinction under certain conditions. Finally, numerical simulations are given to illustrate our main results.


Author(s):  
Sudhakar Yadav ◽  
Vivek Kumar

This study develops a mathematical model for describing the dynamics of the banana-nematodes and its pest detection method to help banana farmers. Two criteria: the mathematical model and the type of nematodes pest control system are discussed. The sensitivity analysis, local stability, global stability, and the dynamic behavior of the mathematical model are performed. Further, we also develop and discuss the optimal control mathematical model. This mathematical model represents various modes of management, including the initial release of infected predators as well as the destroying of nematodes. The theoretical results are shown and verified by numerical simulations.


2014 ◽  
Vol 24 (10) ◽  
pp. 1450133 ◽  
Author(s):  
Haijun Wang ◽  
Xianyi Li

After a 3D Lorenz-like system has been revisited, more rich hidden dynamics that was not found previously is clearly revealed. Some more precise mathematical work, such as for the complete distribution and the local stability and bifurcation of its equilibrium points, the existence of singularly degenerate heteroclinic cycles as well as homoclinic and heteroclinic orbits, and the dynamics at infinity, is carried out in this paper. In particular, another possible new mechanism behind the creation of chaotic attractors is presented. Based on this mechanism, some different structure types of chaotic attractors are numerically found in the case of small b > 0. All theoretical results obtained are further illustrated by numerical simulations. What we formulate in this paper is to not only show those dynamical properties hiding in this system, but also (more mainly) present a kind of way and means — both "locally" and "globally" and both "finitely" and "infinitely" — to comprehensively explore a given system.


2020 ◽  
Vol 12 (11) ◽  
pp. 168781402097552
Author(s):  
Amr MS Mahdy ◽  
Yasser Abd Elaziz Amer ◽  
Mohamed S Mohamed ◽  
Eslam Sobhy

A Caputo–Fabrizio (CF) form a fractional-system mathematical model for the fractional financial models of awareness is suggested. The fundamental attributes of the model are explored. The existence and uniqueness of the suggest fractional financial models of awareness solutions are given through the fixed point hypothesis. The non-number request subordinate gives progressively adaptable and more profound data about the multifaceted nature of the elements of the proposed partial budgetary models of mindfulness model than the whole number request models set up previously. In order to confirm the theoretical results and numerical simulations studies with Caputo derivative are offered.


2014 ◽  
Vol 07 (04) ◽  
pp. 1450045 ◽  
Author(s):  
Qinglai Dong ◽  
Wanbiao Ma

In this paper, we consider a simple chemostat model with inhibitory exponential substrate uptake and a time delay. A detailed qualitative analysis about existence and boundedness of its solutions and the local asymptotic stability of its equilibria are carried out. Using Lyapunov–LaSalle invariance principle, we show that the washout equilibrium is global asymptotic stability for any time delay. Using the fluctuation lemma, the sufficient condition of the global asymptotic stability of the positive equilibrium [Formula: see text] is obtained. Numerical simulations are also performed to illustrate the results.


Author(s):  
Mohsen Jafari ◽  
Hossein Kheiri ◽  
Azizeh Jabbari

In this paper, we consider a tuberculosis model with incomplete treatment and extend the model to a Caputo fractional-order and two-patch version with exogenous re-infection among the treated individuals, in which only susceptible individuals can travel freely between the patches. The model has multiple equilibria. We determine conditions that lead to the appearance of a backward bifurcation. The results show that the TB model can have exogenous reinfection among the treated individuals and, at the same time, does not exhibit backward bifurcation. Also, conditions that lead to the global asymptotic stability of the disease-free equilibrium are obtained. In case without reinfection, the model has four equilibria. In this case, the global asymptotic stability of the equilibria is established using the Lyapunov function theory together with the LaSalle invariance principle for fractional differential equations (FDEs). Numerical simulations confirm the validity of the theoretical results.


2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Isa Abdullahi Baba ◽  
Bashir Abdullahi Baba ◽  
Parvaneh Esmaili

In this paper, we developed a model that suggests the use of robots in identifying COVID-19-positive patients and which studied the effectiveness of the government policy of prohibiting migration of individuals into their countries especially from those countries that were known to have COVID-19 epidemic. Two compartmental models consisting of two equations each were constructed. The models studied the use of robots for the identification of COVID-19-positive patients. The effect of migration ban strategy was also studied. Four biologically meaningful equilibrium points were found. Their local stability analysis was also carried out. Numerical simulations were carried out, and the most effective strategy to curtail the spread of the disease was shown.


2011 ◽  
Vol 16 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Abdelilah Kaddar ◽  
Abdelhadi Abta ◽  
Hamad Talibi Alaoui

In epidemiological research literatures, a latent or incubation period can be medelled by incorporating it as a delay effect (delayed SIR models), or by introducing an exposed class (SEIR models). In this paper we propose a comparison of a delayed SIR model and its corresponding SEIR model in terms of local stability. Also some numerical simulations are given to illustrate the theoretical results.


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