scholarly journals Response of Cortical and Cancellous Bones to Mild Calcium Deficiency in Young Growing Female Rats: A Bone Histomorphometry Study

2004 ◽  
Vol 53 (4) ◽  
pp. 347-354 ◽  
Author(s):  
Jun IWAMOTO ◽  
Tsuyoshi TAKEDA ◽  
Yoshihiro SATO ◽  
James K. YEH
Keyword(s):  
Bone Histomorphometry ◽  
Calcium Deficiency ◽  
Female Rats

Differential effects of gonadal function on bone histomorphometry in male and female rats

2009 ◽  
Vol 4 (4) ◽  
pp. 557-563 ◽  
Author(s):  
Russell T. Turner ◽  
Kathleen S. Hannon ◽  
Laurence M. Demers ◽  
James Buchanan ◽  
Norman H. Bell
Keyword(s):  
Bone Histomorphometry ◽  
Female Rats ◽  
Gonadal Function ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

scholarly journals The Effects ofCosmos caudatuson Structural Bone Histomorphometry in Ovariectomized Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Norazlina Mohamed ◽  
Sharon Gwee Sian Khee ◽  
Ahmad Nazrun Shuid ◽  
Norliza Muhammad ◽  
Farihah Suhaimi ◽  
...  
Keyword(s):  
Bone Histomorphometry ◽  
Therapeutic Agent ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Antioxidant Compounds ◽  
Protective Agent ◽  
Cosmos Caudatus ◽  
Bone Damage ◽  
Trabecular Separation ◽  
Trabecular Number

Osteoporosis is considered a serious debilitating disease.Cosmos caudatus(ulam raja), a plant containing antioxidant compounds and minerals, may be used to treat and prevent osteoporosis. This study determines the effectiveness ofC. caudatusas bone protective agent in postmenopausal osteoporosis rat model. Thirty-two female rats, aged 3 months old, were divided into 4 groups. Group one was sham operated (sham) while group two was ovariectomized. These two groups were given ionized water by forced feeding. Groups three and four were ovariectomized and given calcium 1% ad libitum and force-fed withC. caudatusat the dose of 500 mg/kg, respectively. Treatments were given six days per week for a period of eight weeks. Body weight was monitored every week and structural bone histomorphometry analyses of the femur bones were performed. Ovariectomy decreased trabecular bone volume (BV/TV), decreased trabecular number (Tb.N), and increased trabecular separation (Tb.Sp). Both calcium 1% and 500 mg/kgC. caudatusreversed the above structural bone histomorphometric parameters to normal level.C. caudatusshows better effect compared to calcium 1% on trabecular number (Tb.N) and trabecular separation (Tb.Sp). Therefore,Cosmos caudatus500 mg/kg has the potential to act as the therapeutic agent to restore bone damage in postmenopausal women.

Effect of Oophorectomy and Calcium Deprivation on Bone Mass in the Rat

1978 ◽  
Vol 54 (4) ◽  
pp. 439-446 ◽  
Author(s):  
A. Hodgkinson ◽  
Jean E. Aaron ◽  
A. Horsman ◽  
M. S. F. McLachlan ◽  
B. E. C. Nordin
Keyword(s):  
Bone Mass ◽  
Trabecular Bone ◽  
Dry Weight ◽  
Calcium Deficiency ◽  
Normal Diet ◽  
Female Rats ◽  
Cross Sectional ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium

1. The effects of a low calcium diet and of oophorectomy, separately and together, on cortical and trabecular bone mass, have been examined in mature female rats. 2. Calcium deprivation caused a significant decrease of weight, cortical cross-sectional area and ratio of cortical to total area in the femur, it significantly reduced the volume of trabecular bone and increased the percentage of osteoid surface in the tail vertebrae, and in addition increased the urinary excretion of phosphate and, initially, of hydroxyproline. 3. Oophorectomy caused similar though smaller changes in trabecular bone and urine, whereas the effects of oophorectomy on cortical bone were greater on a low calcium intake than on a normal intake. 4. The ash weight of the femora, expressed as a percentage of the total dry weight, was unaffected by calcium deprivation or oophorectomy alone but was significantly reduced when the two occurred together. 5. The percentage of resorption surfaces in the vertebrae tended to increase on the low calcium diet and after oophorectomy on the normal diet but decreased after oophorectomy on a low calcium diet. 6. It is concluded that oophorectomy and calcium deficiency each reduce bone mass in the adult rat but the greatest effect is seen when they are combined.

Mechanical loading attenuates bone loss due to immobilization and calcium deficiency

1999 ◽  
Vol 87 (1) ◽  
pp. 189-195 ◽  
Author(s):  
Cynthia L. Inman ◽  
Gordon L. Warren ◽  
Harry A. Hogan ◽  
Susan A. Bloomfield
Keyword(s):  
Bone Mineral Density ◽  
Mechanical Loading ◽  
Bone Mineral ◽  
Ultimate Load ◽  
Calcium Deficiency ◽  
Female Rats ◽  
Tibial Shaft ◽  
Mineral Density ◽  
Cross Sectional ◽  
High Bone

Our purpose was to determine the effects of a mechanical loading intervention on mass, geometry, and strength of rat cortical bone during a period of disuse concurrent with calcium deficiency (CD). Adult female rats were assigned to unilateral hindlimb immobilization, immobilized-loaded, or control (standard chow, 1.85% calcium) treatments. Both immobilized groups were fed a CD rat chow (0.01% calcium) to induce high bone turnover. Three times weekly, immobilized-loaded rats were subjected to 36 cycles of 4-point bending of the immobilized lower leg. After 6 wk, the immobilized rats exhibited decreased tibial shaft bone mineral density (−12%), ultimate load (−19%), and stiffness (−20%; tested in 3-point bending to failure) vs. control rats. Loading prevented this decline in bone density and attenuated decreases in ultimate load and stiffness. Elastic modulus was unaffected by disuse or loading. Bone cross-sectional area in the immobilized-loaded rats was equivalent to that of control animals, even though endocortical resorption continued unabated. On the medial periosteum, percent mineralizing surface doubled vs. that in immobilized rats. This loading regimen stimulated periosteal mineralization and maintained bone mineral density, thereby attenuating the loss in bone strength incurred with disuse and concurrent calcium deficiency.

Skeletal sensitivity to dietary calcium deficiency is increased in the female compared with the male rat

2001 ◽  
Vol 79 (5) ◽  
pp. 379-385 ◽  
Author(s):  
W Geng ◽  
G L Wright
Keyword(s):  
Bone Resorption ◽  
Bone Mass ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Female Rats ◽  
Male Rats ◽  
Male Rat ◽  
Calcium Diet ◽  
Dietary Calcium Deficiency ◽  
Body Bone

We investigated potential sex differences in bone resorption and the conservation of whole body bone mass in 24-week-old Sprague-Dawley rats maintained on a 1.0% calcium diet and then fed diets containing 0.02, 0.5, 1.0, or 1.75% calcium for 31 days. Lowering dietary calcium from 1.00% to 0.02% doubled whole skeleton bone resorption (urinary 3H-tetracycline loss). Female rats were more sensitive to calcium stress, exhibiting the maximal resorptive response when fed the 0.5% calcium diet, whereas the 0.02% calcium diet was required to elicit this response in males. Despite the evidence of increased bone resorption, whole skeleton mass was unchanged in females and was significantly increased in males, indicating that switching to even the 0.02% calcium diet did not result in an overt loss of total body bone mass. Compared with controls, the skeleton mass of females (97 ± 1.4%) maintained on the 0.02% calcium diet was significantly lower than males (107 ± 2.4%), again suggesting a greater impact of calcium deficiency in females. The calculation of the average percentage growth of selected individual bones in male rats indicated a proportional increase in bone mass between the axial and appendicular skeleton of approximately +4% and +18% in animals maintained on 0.02 and 1.75% diets, respectively. By comparison, female rats consuming the 0.02% calcium diet showed an average 14% loss in axial bone and 7.5% gain in appendicular bone mass. The results indicate increased sensitivity to dietary calcium deficiency in female rats which involves a significant loss in axial bone mass not observed in male rats maintained under similar dietary conditions.Key words: skeleton bone mass, calcium diet, 3H-tetracycline, axial, appendicular, gender, sex.

Effects of ovariectomy and calcium deficiency on learning and memory of eight-arm radial maze in middle-aged female rats

2003 ◽  
Vol 142 (1-2) ◽  
pp. 207-216 ◽  
Author(s):  
Tomoaki Sato ◽  
Toyonori Teramoto ◽  
Koh-ichi Tanaka ◽  
Yoshiko Ohnishi ◽  
Masahiro Irifune ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Radial Maze ◽  
Calcium Deficiency ◽  
Female Rats ◽  
Middle Aged
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