scholarly journals Diurnal Variation of Heart Rate, Locomotor Activity, and Body Temperature in Interleukin-1.ALPHA./.BETA. Doubly Deficient Mice.

2002 ◽  
Vol 51 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Masashi FURUZAWA ◽  
Masayoshi KUWAHARA ◽  
Keiji ISHII ◽  
Yoichiro IWAKURA ◽  
Hirokazu TSUBONE
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Body Temperature ◽  
Diurnal Variation ◽  
Interleukin 1 ◽  
Alpha Beta ◽  
Deficient Mice

Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice

2011 ◽  
Vol 300 (3) ◽  
pp. R519-R530 ◽  
Author(s):  
Jens Hannibal ◽  
Hansen M. Hsiung ◽  
Jan Fahrenkrug
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Body Temperature ◽  
Circadian Rhythms ◽  
Wheel Running ◽  
Core Body Temperature ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Core Body ◽  
Deficient Mice

Neurons of the brain's biological clock located in the hypothalamic suprachiasmatic nucleus (SCN) generate circadian rhythms of physiology (core body temperature, hormone secretion, locomotor activity, sleep/wake, and heart rate) with distinct temporal phasing when entrained by the light/dark (LD) cycle. The neuropeptide vasoactive intestinal polypetide (VIP) and its receptor (VPAC2) are highly expressed in the SCN. Recent studies indicate that VIPergic signaling plays an essential role in the maintenance of ongoing circadian rhythmicity by synchronizing SCN cells and by maintaining rhythmicity within individual neurons. To further increase the understanding of the role of VPAC2 signaling in circadian regulation, we implanted telemetric devices and simultaneously measured core body temperature, spontaneous activity, and heart rate in a strain of VPAC2-deficient mice and compared these observations with observations made from mice examined by wheel-running activity. The study demonstrates that VPAC2 signaling is necessary for a functional circadian clock driving locomotor activity, core body temperature, and heart rate rhythmicity, since VPAC2-deficient mice lose the rhythms in all three parameters when placed under constant conditions (of either light or darkness). Furthermore, although 24-h rhythms for three parameters are retained in VPAC2-deficient mice during the LD cycle, the temperature rhythm displays markedly altered time course and profile, rising earlier and peaking ∼4–6 h prior to that of wild-type mice. The use of telemetric devices to measure circadian locomotor activity, temperature, and heart rate, together with the classical determination of circadian rhythms of wheel-running activity, raises questions about how representative wheel-running activity may be of other behavioral parameters, especially when animals have altered circadian phenotype.

Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-β or both α1 and β

1999 ◽  
Vol 276 (6) ◽  
pp. H2006-H2012 ◽  
Author(s):  
Catarina Johansson ◽  
Sten Göthe ◽  
Douglas Forrest ◽  
Björn Vennström ◽  
Peter Thorén
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Thyroid Hormone ◽  
Body Temperature ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Serum Levels ◽  
Hormone Treatment ◽  
Different Strains ◽  
Deficient Mice

We have used a telemetry system to record heart rate, body temperature, electrocardiogram (ECG), and locomotor activity in awake, freely moving mice lacking thyroid hormone receptor (TR)-β or TR-α1 and -β (TR-α1/β). The TR-α1/β-deficient mice had a reduced heart rate compared with wild-type controls. The TR-β-deficient mice showed an elevated heart rate, which, however, was unresponsive to thyroid hormone treatment regardless of hormonal serum levels. ECG revealed that the TR-β-deficient mice had a shortened Q-Tend time in contrast to the TR-α1/β-deficient mice, which exhibited prolonged P-Q and Q-Tend times. Mental or pharmacological stimulation of the sympathetic nervous system resulted in a parallel increase in heart rate in all animals. A single injection of a nonselective β-adrenergic-receptor blocker resulted in a parallel decrease in all mice. The TR-α1/β-deficient mice also had a 0.4°C lower body temperature than controls, whereas no difference was observed in locomotor activity between the different strains of mice. Our present and previous results support the hypothesis that TR-α1 has a major role in determining heart rate under baseline conditions and body temperature and that TR-β mediates a hormone-induced increase in heart rate.

scholarly journals A versatile telemetry system for continuous measurement of heart rate, body temperature and locomotor activity in free-ranging ruminants

2010 ◽  
Vol 1 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Claudio Signer ◽  
Thomas Ruf ◽  
Franz Schober ◽  
Gerhard Fluch ◽  
Thomas Paumann ◽  
...  
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Body Temperature ◽  
Continuous Measurement ◽  
Telemetry System ◽  
Free Ranging

scholarly journals Heart rate sensor validation and seasonal and diurnal variation of body temperature and heart rate in domestic sheep

2019 ◽  
Vol 8 ◽  
pp. 100075 ◽  
Author(s):  
Boris Fuchs ◽  
Kristin Marie Sørheim ◽  
Matteo Chincarini ◽  
Emma Brunberg ◽  
Solveig Marie Stubsjøen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Diurnal Variation ◽  
Domestic Sheep ◽  
Sensor Validation ◽  
Seasonal And Diurnal Variation ◽  
Rate Sensor

scholarly journals The Daily Pattern of Heart Rate, Body Temperature, and Locomotor Activity in Guinea Pigs.

2001 ◽  
Vol 50 (5) ◽  
pp. 409-415 ◽  
Author(s):  
Megumi AKITA ◽  
Keiji ISHII ◽  
Masayoshi KUWAHARA ◽  
Hirokazu TSUBONE
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Body Temperature ◽  
Guinea Pigs ◽  
Daily Pattern

scholarly journals Effects of Perches on Behavior, Heart Rate, Body Temperature and Locomotor Activity of Caged Hens

2004 ◽  
Vol 41 (2) ◽  
pp. 120-130 ◽  
Author(s):  
Kanji Matsui ◽  
Ashraf M. Khalil ◽  
Ken-ichi Takeda
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Body Temperature

Abstract P167: Chronic Circadian Disruption Impairs Cardiovascular Rhythms In Mice

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Paramita Pati ◽  
Megan K Rhoads ◽  
Rachel Meek ◽  
Jackson Colson ◽  
David M Pollock ◽  
...  
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Diurnal Variation ◽  
Disease Risk ◽  
Time Of Day ◽  
Circadian Disruption ◽  
Dark Phase ◽  
Light Cycle ◽  
Dark Control ◽  
Increased Risk

Shift workers have an increased risk of developing hypertension and higher incidence of metabolic syndrome. Circadian rhythm disruption increases cardiometabolic disease risk in humans and animals. We hypothesized that chronic circadian disruption (CCD) disrupts blood pressure, heart rate, and locomotor activity rhythms. Male 8-week old C57BL/6J mice were under a standard light/dark cycle (12-h light, 12-h dark, control) or a CCD protocol (10-h light, 10-h dark, T20) with ad libitum food and water for 10 weeks. T20 mice gained significantly more body weight (n=6, p=0.04; time: p<0.001, light cycle: p<0.001). Mean arterial pressure (MAP), heart rate (HR), and locomotor activity were measured by telemetry after 10 weeks of CCD. Average MAP, HR, and activity were calculated during light and dark periods. MAP between the light and dark periods was significantly different in control mice (12:12 LD), while T20 mice (10:10 LD) did not show diurnal variation (Control 119±3 mm Hg vs.101±2 mm Hg, dark vs. light, respectively, p<0.001; T20 114±13 mm Hg vs.113±12 mm Hg, dark vs. light, respectively, p=0.86; n=3-4 in all groups). Control mice showed a diurnal variation in HR, whereas T20 mice did not show a light-dark difference (Control 584±11 bpm Hg vs. 511±4 bpm, dark vs. light, respectively, p=0.001; T20 537±14 bpm vs. 526±5 bpm, dark vs. light, respectively, p=0.48; n=3-4 in all groups). Dark phase HR was significantly decreased in T20 mice (p=0.01, control dark vs. T20 dark). Control mice showed a light-dark difference in activity, while T20 mice lacked diurnal variation in the activity rhythm (Control 9.6±1.3 counts/min Hg vs. 3.1±0.3 counts/min, dark vs. light, respectively, p<0.001; T20 6.9±0.3 counts/min vs. 6.0±0.8 counts/min, dark vs. light, respectively, p=0.92; n=3-4 in all groups). T20 mice also displayed significantly higher activity during the light phase (p=0.04, control light vs. T20 light). Time of day and the interaction between time of day and light cycle, respectively, were significant between control and T20 mice for MAP, HR, and activity (n=3-4, MAP: p=0.001 and p=0.002; HR: p=0.001 and p=0.004; Activity: p=0.001 and p=0.004). These results indicate that CCD impairs cardiovascular and behavioral rhythms, which may lead to cardiovascular disease.

Sign in / Sign up

Export Citation Format

Share Document