scholarly journals Effects of Chronic Administration of Sibutramine on Body Weight, Food Intake and Motor Activity in Neonatally Monosodium Glutamate-Treated Obese Female Rats: Relationship of Antiobesity Effect with Monoamines

2000 ◽  
Vol 49 (4) ◽  
pp. 239-249 ◽  
Author(s):  
Terutake NAKAGAWA ◽  
Kiyoharu UKAI ◽  
Tadashi OHYAMA ◽  
Yutaka GOMITA ◽  
Hitoshi OKAMURA
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Motor Activity ◽  
Monosodium Glutamate ◽  
Chronic Administration ◽  
Female Rats ◽  
Obese Female ◽  
Relationship Of

Early-onset repeated dieting reduces food intake and body weight but not adiposity in dietary-obese female rats

1992 ◽  
Vol 51 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Leslie J. Stein ◽  
Eliot Stellar ◽  
David B. West ◽  
M.R.C. Greenwood ◽  
Gary D. Foster ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Early Onset ◽  
Female Rats ◽  
Obese Female

Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats

1998 ◽  
Vol 275 (1) ◽  
pp. R186-R193 ◽  
Author(s):  
Lisa A. Eckel ◽  
Wolfgang Langhans ◽  
Andrea Kahler ◽  
L. Arthur Campfield ◽  
Françoise J. Smith ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Wheel Running ◽  
Chronic Administration ◽  
Meal Size ◽  
Female Rats ◽  
Maximum Decrease ◽  
Wheel Activity ◽  
Ob Protein ◽  
Ovarian Cycles

The mechanisms by which OB protein controls food intake and energy balance are unknown. Therefore, we investigated the effects of a novel modified human recombinant OB protein (Mod-OB) on spontaneous feeding patterns, body weight, running wheel activity, and ovarian cycling in female rats. Mod-OB or vehicle was injected (4 mg ⋅ kg−1 ⋅ day−1sc) for 2 ovarian cycles (8 days) using a within-subjects design. Observations were continued for five ovarian cycles after injections; treatments were then reversed. Mod-OB reduced food intake ∼20% from injection day 1 to postinjection day 2. Body weight was reduced from injection day 3 to postinjection day 15 (maximum decrease, 25 ± 4 g, postinjection days 3 and 4). Food intake was reduced due to decreases in nocturnal meal size, which appeared to be superimposed on the normal pattern of spontaneous feeding (i.e., reductions in meal size at estrus). Mod-OB did not significantly affect diurnal food intake or meal patterns, failed to alter wheel running, and did not disrupt the rats’ ovarian cycles. We conclude that chronically administered Mod-OB reduces food intake in female rats by selectively affecting the mechanisms controlling meal size.

Relationship between water and food ingestion in the rat

1965 ◽  
Vol 208 (4) ◽  
pp. 615-620 ◽  
Author(s):  
L. J. Cizek ◽  
M. R. Nocenti
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Water Intake ◽  
The Body ◽  
Female Rats ◽  
Food Ingestion ◽  
Constant Composition ◽  
Male And Female Rats ◽  
Daily Water Intake ◽  
Relationship Of

Daily observations for 3 months on the ad libitum water-to-food-intake relationship were made on young Sherman male and female rats subsisting on a diet of constant composition, with particular attention being given to the influence on this relationship of handling, weight, and sex. The 1st-week values for water intake in rats not handled prior to experimentation were always higher than subsequent trends and higher than those for previously handled rats. Though water intake increased as body weight increased, this dependence was slight (+.03–.05 ml/g increase in body wt) as contrasted to its dependence upon food intake (+.75 ml/g increase in food ingested). Since the body weight increased faster than the increase in food, the portion of water related to body weight comprised the greater fraction of the total daily water intake. While both absolute intakes continued to increase with time, water intake increased at a greater rate than food ingestion. Thus, the water-to-food ratio gradually increased. These findings obtained for both sexes.

Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

2021 ◽  
Vol 4 (1) ◽  
pp. 99-114
Author(s):  
Janaína B Garcia ◽  
Fernanda G Do Amaral ◽  
Daniela C Buonfiglio ◽  
Rafaela FA Vendrame ◽  
Patrícia L Alves ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Pineal Gland ◽  
Serum Insulin ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Pineal Melatonin ◽  
Melatonin Synthesis ◽  
Male And Female Rats ◽  
Melatonin Production

The pineal gland synthesizes melatonin exclusively at night, which gives melatonin the characteristic of a temporal synchronizer of the physiological systems. Melatonin is a regulator of insulin activities centrally and also peripherally and its synthesis is reduced in diabetes.  Since monosodium glutamate (MSG) is often used to induce the type 2 diabetic and metabolic syndrome in animal models, the purpose of this work is to evaluate the potential effects of MSG given to neonates on the pineal melatonin synthesis in different aged male and female rats. Wistar rats were subcutaneously injected with MSG (4mg/g/day) or saline solution (0.9%) from the second to eighth post-natal day. The circadian profiles both melatonin levels and AANAT activity were monitored at different ages. Body weight, naso-anal length, adipose tissues weight, GTT, ITT and serum insulin levels were also evaluated. Typical obesity with the neonatal MSG treatment was observed, indicated by a great increase in adipose depots without a concurrent increase in body weight. MSG treatment did not cause hyperglycemia or glucose intolerance, but induced insulin resistance. An increase of melatonin synthesis at ZT 15 with phase advance was observed in in some animals. The AANAT activity was positively parallel to the melatonin circadian profile. It seems that MSG causes hypothalamic obesity which may increase AANAT activity and melatonin production in pineal gland. These effects were not temporally correlated with insulin resistance and hyperinsulinemia indicating the hypothalamic lesions, particularly in arcuate nucleus induced by MSG in early age, as the principal cause of the increase in melatonin production.

Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat

1981 ◽  
Vol 240 (1) ◽  
pp. E72-E78 ◽  
Author(s):  
M. R. Greenwood ◽  
M. P. Cleary ◽  
R. Gruen ◽  
D. Blase ◽  
J. S. Stern ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Cell Size ◽  
Treatment Period ◽  
Body Fat ◽  
Substantial Reduction ◽  
Female Rats ◽  
Fat Cell ◽  
Fat Cell Size ◽  
Obese Rats

Young Zucker lean (Fa/-) and obese (fa/fa) female rats were fed the fatty acid synthesis inhibitor (-)-hydroxy-citrate as a dietary admixture for 39 days. In the lean rats, (-)-hydroxycitrate treatment decreased body weight, food intake, percent of body fat, and fat cell size. In the obese rat, food intake and body weight were reduced but the percent of body fat remained unchanged. Throughout the treatment period, obese rats maintained a fat cell size equivalent to their obese controls. Although a reduction in fat cell number in the obese rats occurred during the treatment period, marked hyperplasia was observed during the posttreatment period. The results of this study indicate that the obese rat, despite a substantial reduction in body weight produced by (-)-hydroxycitrate, still defends its obese body composition.

Exacerbated febrile responses to LPS, but not turpentine, in TNF double receptor-knockout mice

1997 ◽  
Vol 272 (2) ◽  
pp. R563-R569 ◽  
Author(s):  
L. R. Leon ◽  
W. Kozak ◽  
J. Peschon ◽  
M. J. Kluger
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Motor Activity ◽  
Knockout Mice ◽  
Low Dose ◽  
Late Phase ◽  
High Dose ◽  
Wild Type ◽  
Inflammatory Stimuli ◽  
Necrosis Factor

We examined the effects of injections of systemic [lipopolysaccharide (LPS), 2.5 mg/kg or 50 pg/kg ip] or local (turpentine, 100 microl sc) inflammatory stimuli on fever, motor activity, body weight, and food intake in tumor necrosis factor (TNF) double receptor (TNFR)-knockout mice. A high dose of LPS resulted in exacerbated fevers in TNFR-knockout mice compared with wild-type mice for the early phase of fever (3-15 h); the late phase of fever (16-24 h) and fevers to a low dose of LPS were similar in both groups. Motor activity, body weight, and food intake were similarly reduced in both groups of mice after LPS administration. In response to turpentine, TNFR-knockout and wild-type mice developed virtually identical responses to all variables monitored. These results suggest that 1) TNF modulates fevers to LPS dose dependently, 2) TNF does not modulate fevers to a subcutaneous injection of turpentine, and 3) knockout mice may develop cytokine redundancy in the regulation of the acute phase response to intraperitoneally injected LPS or subcutaneously injected turpentine.

BODY WEIGHT AND FOOD CONSUMPTION OF LACTATING RATS NURSING VARIOUS SIZES OF LITTERS

1967 ◽  
Vol 38 (3) ◽  
pp. 263-268 ◽  
Author(s):  
K. ÔTA ◽  
A. YOKOYAMA
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Food Consumption ◽  
Ovarian Function ◽  
Experimental Period ◽  
Close Correlation ◽  
Female Rats ◽  
Linear Relationships ◽  
Rate Of Increase ◽  
Daily Gain

SUMMARY Changes in body weight and food consumption during lactation in rats nursing various sizes of litters were studied. The rate of increase in body weight of the mother rats during the experimental period (day 3–14 of lactation) was very similar in mothers with different numbers (2, 4, 8 and 12) of suckling pups/litter. It is suggested that the weight increase of adult female rats during lactation is related more closely to the alteration of ovarian function caused by the suckling stimulus than to the enhanced food intake during this period. Both the food intake of mother rats and the daily gain in weight of litters increased as the number of suckling pups/litter increased and as lactation advanced. Linear relationships were observed between the logarithm of the litter size and both the food intake of the mother rats and the weight gain of the litters. The presence of a close correlation between the food intake of mother rats and the quantity of milk produced by them is suggested.

Long-term effects of exogenous leptin on body weight and fat in post-obese female rats

2001 ◽  
Vol 74 (3) ◽  
pp. 321-328 ◽  
Author(s):  
Anne Buison ◽  
Frank Ordiz ◽  
K.-L.Catherine Jen
Keyword(s):  
Body Weight ◽  
Female Rats ◽  
Long Term Effects ◽  
Obese Female

Impeded Eruption Rate of the Rat Maxillary Incisor During Exposure to Different Simulated Altitudes

1987 ◽  
Vol 66 (9) ◽  
pp. 1490-1492 ◽  
Author(s):  
M.J. Giglio ◽  
A.M. Sanz ◽  
A. Constanzo ◽  
C.E. Bozzini
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Sea Level ◽  
Body Length ◽  
Conclusive Evidence ◽  
Female Rats ◽  
Maxillary Incisor ◽  
Eruption Rate ◽  
Insight Into

Female rats weighing about 200 g each were separated into normoxic and hypoxic groups. The former were maintained at sea-level conditions. The hypoxic groups were placed in an altitude chamber and maintained at the equivalent of 1850 m, 4100 m, or 7100 m over a period of two weeks. Hematocrit, body weight, body length, and impeded eruption rate were recorded once a week. Food intake was recorded every day. Exposure to 1850 m did not significantly alter hematocrit, body weight and body length gains, food intake, and impeded eruption rate. Nevertheless, exposure to 4100 m and 7100 m decreased body weight and body length gains, food intake, and impeded eruption rate, and increased hematocrit value. These parameters varied as a function of altitude. In spite of the lack of conclusive evidence, this work affords further insight into the particular significance of polycythemia on the eruption rate.

scholarly journals Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats

Life Sciences ◽  
2007 ◽  
Vol 81 (12) ◽  
pp. 1024-1030 ◽  
Author(s):  
SuJean Choi ◽  
Briana DiSilvio ◽  
JayLynn Unangst ◽  
John D. Fernstrom
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Chronic Infusion
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