Selective Attachment of Luminophore-Bearing Emulsion to Diamonds-Mechanism Analysis and Mode Selection

2020 ◽  
Keyword(s):  
Mode Selection ◽  
Mechanism Analysis

Selective Attachment of Luminophore-Bearing Emulsion at Diamonds—Mechanism Analysis and Mode Selection

2020 ◽  
Vol 56 (1) ◽  
pp. 96-103 ◽  
Author(s):  
V. A. Chanturia ◽  
G. P. Dvoichenkova ◽  
V. V. Morozov ◽  
O. E. Koval’chuk ◽  
Yu. A. Podkamennyi ◽  
...  
Keyword(s):  
Mode Selection ◽  
Mechanism Analysis

Mechanism analysis and application of cement-soil mixing pile in soft roadbed treatment

2018 ◽  
Vol 28 (2) ◽  
pp. 161-172
Author(s):  
JUNHUI LUO ◽  
XIANLIN LIU ◽  
HAIFENG HUANG ◽  
DECAI MI ◽  
DEQIANG CHE
Keyword(s):  
Mechanism Analysis ◽  
Soil Mixing ◽  
Cement Soil

Research and Implementation of Fast Algorithm for Intra Prediction Mode Selection Oriented to Hardware

2019 ◽  
Vol 31 (1) ◽  
pp. 158
Author(s):  
Xiuzhi Yang ◽  
Min Zhao ◽  
Longzhao Shi ◽  
Zhifeng Chen ◽  
Mingkui Zheng
Keyword(s):  
Fast Algorithm ◽  
Mode Selection ◽  
Intra Prediction ◽  
Prediction Mode

scholarly journals CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-β1 axis

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Hong-Xing Liao ◽  
Zhi-Hui Zhang ◽  
Hui-Lin Chen ◽  
Ying-Mei Huang ◽  
Zhan-Liang Liu ◽  
...  
Keyword(s):  
Transforming Growth Factor ◽  
Pathological Examination ◽  
Circular Rnas ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mechanism Analysis ◽  
Gain Of Function ◽  
Qrt Pcr ◽  
Intact Cartilage ◽  
Ha Synthase ◽  
Tgf Β1

Abstract Background Hyaluronan (HA) metabolism by chondrocytes is important for cartilage development and homeostasis. However, information about the function of circular RNAs (circRNAs) in HA metabolism is limited. We therefore profiled the role of the novel HA-related circRNA circHYBID in the progression of osteoarthritis (OA). Methods CircHYBID function in HA metabolism in chondrocytes was investigated using gain-of-function experiments, and circHYBID mechanism was confirmed via bioinformatics analysis and luciferase assays. The expression of circHYBID–hsa-miR-29b-3p–transforming growth factor (TGF)-β1 axis was examined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting. CircHYBID, TGF-β1, and HA levels in cartilage samples were evaluated using qRT-PCR and pathological examination. Enzyme-linked immunosorbent assay was used to assess HA accumulation in chondrocyte supernatant. Results CircHYBID expression was significantly downregulated in damaged cartilage samples compared with that in the corresponding intact cartilage samples. CircHYBID expression was positively correlated with alcian blue score. Interleukin-1β stimulation in chondrocytes downregulated circHYBID expression and decreased HA accumulation. Gain-of-function experiments revealed that circHYBID overexpression in chondrocytes increased HA accumulation by regulating HA synthase 2 and HYBID expression. Further mechanism analysis showed that circHYBID upregulated TGF-β1 expression by sponging hsa-miR-29b-3p. Conclusions Our results describe a novel HA-related circRNA that could promote HA synthesis and accumulation. The circHYBID–hsa-miR-29b-3p–TGF-β1 axis may play a powerful regulatory role in HA metabolism and OA progression. Thus, these findings will provide new perspectives for studies on OA pathogenesis, and circHYBID may serve as a potential target for OA therapy.

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