ATORVASTATIN LOADING DOSE BEFORE INTRACORONARY INTERVENTION PROVIDES PROTECTIVE EFFECT IN PATIENTS WITH CHRONIC ATHEROSCLEROTIC TOTAL OCCLUSION OF CORONARY ARTERIES

2018 ◽  
Keyword(s):  
Protective Effect ◽  
Coronary Arteries ◽  
Loading Dose ◽  
Total Occlusion

Abstract 16567: Long-Term Vascular Function in CTO Recanalization. A Randomized Clinical Trial of Ticagrelor vs. Clopidogrel

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Juan Jose Rodriguez Arias ◽  
Josep Gomez-Lara ◽  
Juan Caballero-Borrego ◽  
Luis Ortega-Paz ◽  
Luis Teruel ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vascular Function ◽  
Drug Loading ◽  
Controlled Clinical Trial ◽  
Loading Dose ◽  
Clinical Value ◽  
Open Label ◽  
Total Occlusion

Background: Coronary vascular function of a chronic coronary total occlusion (CTO) immediately after recanalization is known to be poor and to be partially improved by pre-treatment with loading dose of ticagrelor vs. clopidogrel. It is unknown if this vascular dysfunction is maintained at long-term follow-up and may be improved by 1-year dual antiplatelet therapy (DAPT) with ticagrelor vs. clopidogrel. Methods: The TIGER is a prospective, open-label, two parallel-group controlled clinical trial, which 1:1 randomized 50 CTO patients to pre-PCI loading dose and subsequent 1-year DAPT with ticagrelor vs. clopidogrel. Coronary blood flow (CBF) under stepwise adenosine infusion was assessed after drug loading dose and at follow-up and compared between the two drug groups, adjusting for time of follow-up. Results: Out of 50 patients with index CBF evaluation, 38 (76%) patients underwent angiographic follow-up (23 and 15 at 1 and 3-year, respectively). A higher CBF area under the curve (AUC), already observed after loading dose in ticagrelor vs. clopidogrel group (p=0.027), was maintained at follow-up (AUC 34815.22±24206.06 vs. AUC 22712.47±13768.95; p=0.071). Specifically, whereas high ticagrelor loading dose-related CBF was sustained at follow-up (p=0.933), clopidogrel loading dose-related CBF increased at follow-up (p=0.039). Conclusion: The TIGER trial showed that DAPT with ticagrelor may maintain a higher CBF in a recanalized CTO as compared to clopidogrel, whose treated patients exhibit a lower CBF immediately after PCI with slight increase at follow-up. The clinical value of such sustained higher coronary flow should be evaluated in a larger group of patients.

Methylergometrine-induced coronary artery spasm causing total occlusion of all three coronary arteries

1990 ◽  
Vol 11 (12) ◽  
pp. 1127-1129 ◽  
Author(s):  
N. DANCHIN ◽  
CH. SELTON-SUTY ◽  
Y. JUILLIERE ◽  
J.-P. LETHOR ◽  
F. CHERRIER
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Coronary Artery Spasm ◽  
Total Occlusion

scholarly journals A Novel Modification of the Retrograde Approach for the Recanalization of Chronic Total Occlusion of the Coronary Arteries

2010 ◽  
Vol 3 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Sudhir Rathore ◽  
Osamu Katoh ◽  
Etsuo Tuschikane ◽  
Akitsugu Oida ◽  
Takahiko Suzuki ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Chronic Total Occlusion ◽  
Retrograde Approach ◽  
Total Occlusion

scholarly journals Usefulness and Safety of a Novel Modification of the Retrograde Approach for the Long Tortuous Chronic Total Occlusion of Coronary Arteries

2017 ◽  
Vol 58 (3) ◽  
pp. 351-356 ◽  
Author(s):  
Zehan Huang ◽  
Bin Zhang ◽  
Weilu Chai ◽  
Dunliang Ma ◽  
Hongtao Liao ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Chronic Total Occlusion ◽  
Retrograde Approach ◽  
Total Occlusion
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