scholarly journals Effects of Subconjunctival Injection of Anti-Vascular Endothelial Growth Factor Antibody on Oxygen-Induced Ischemic Retinopathy in a Neonatal Rat Model

2012 ◽  
Vol 24 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Junkichi KABAYAMA ◽  
Yuta SAITO ◽  
Takako NAKANISHI-UEDA ◽  
Toshihiko UEDA ◽  
Michiko MATSUBARA ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Rat Model ◽  
Neonatal Rat ◽  
Subconjunctival Injection ◽  
Vascular Endothelial ◽  
Ischemic Retinopathy ◽  
Endothelial Growth Factor ◽  
Neonatal Rat Model

scholarly journals Telomerase Mediates Vascular Endothelial Growth Factor-dependent Responsiveness in a Rat Model of Hind Limb Ischemia

2005 ◽  
Vol 280 (15) ◽  
pp. 14790-14798 ◽  
Author(s):  
Germana Zaccagnini ◽  
Carlo Gaetano ◽  
Linda Della Pietra ◽  
Simona Nanni ◽  
Annalisa Grasselli ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Rat Model ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Vascular Endothelial ◽  
Hind Limb Ischemia ◽  
Endothelial Growth Factor

THE EFFECT OF VASCULAR ENDOTHELIAL GROWTH FACTOR ON A RAT MODEL OF TRAUMATIC ARTERIOGENIC ERECTILE DYSFUNCTION

2002 ◽  
Vol 167 (2 Part 1) ◽  
pp. 761-767 ◽  
Author(s):  
MING-CHAN LEE ◽  
AHMED I. EL-SAKKA ◽  
TULIO M. GRAZIOTTIN ◽  
HAO-CHUNG HO ◽  
CHING-SHWUN LIN ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Erectile Dysfunction ◽  
Growth Factor ◽  
Rat Model ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

THE EFFECT OF VASCULAR ENDOTHELIAL GROWTH FACTOR ON A RAT MODEL OF TRAUMATIC ARTERIOGENIC ERECTILE DYSFUNCTION

2002 ◽  
pp. 761-769 ◽  
Author(s):  
MING-CHAN LEE ◽  
AHMED I. EL-SAKKA ◽  
TULIO M. GRAZIOTTIN ◽  
HAO-CHUNG HO ◽  
CHING-SHWUN LIN ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Erectile Dysfunction ◽  
Growth Factor ◽  
Rat Model ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Fracture Healing and Biomarker Expression in a Diabetic Zucker Rat Model

2014 ◽  
Vol 104 (5) ◽  
pp. 428-433 ◽  
Author(s):  
Javier La Fontaine ◽  
Nathan A. Hunt ◽  
Stacey Curry ◽  
Tyler Kearney ◽  
Daniel Jupiter ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Fracture Healing ◽  
Bone Healing ◽  
Rat Model ◽  
Healing Process ◽  
Diabetic Rats ◽  
Vascular Endothelial ◽  
Delayed Healing ◽  
Endothelial Growth Factor

Background Persons with diabetes have a higher incidence of fractures compared with persons without diabetes. However, there is little published information concerning the deleterious effect of late-stage diabetes on fracture healing. There are no studies using animal models that evaluate the effect of advanced diabetes on fracture healing. The purpose of our study was to evaluate cytokine expression, specifically macrophage inflammatory protein 1 (MIP-1) and vascular endothelial growth factor, in fracture healing in a type 2 diabetes rat model. Methods We evaluated biomarker expression after femur fracture using a rat model. The two groups consisted of 24 Zucker diabetic rats (study group) and 12 Zucker lean rats (control group). An independent reviewer was used to assess delayed union. We evaluated serum samples 2, 4, 7, and 14 days after surgery for MIP-1, vascular endothelial growth factor, leptin, and other cytokine levels. Results At 3 weeks, Kaplan-Meier estimates showed that 45.8% of femur fractures in Zucker diabetic rats had healed, whereas 81.8% of those in Zucker lean rats had healed (P = .02). A logistic regression model to predict fast healing that included the three cytokines and diabetes status showed that the only factor achieving significance was MIP-1α. Vascular endothelial growth factor was the only biomarker to show significance compared with delayed healing. Conclusions These results confirm significant differences in biomarker expression between diabetic and nondiabetic rats during bone healing. The key factors for bone healing may appear early in the healing process, whereas differences in diabetes versus nondiabetes are seen later in the healing process. Increased levels of MIP-1α were associated with the likelihood of delayed healing.

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