scholarly journals Association between Aldehyde Dehydrogenase-2 Gene Polymorphisms and Consumption of Alcohol in the Precursor Lesions of Esophageal Squamous Cell Carcinoma

2009 ◽  
Vol 21 (1) ◽  
pp. 67-76
Author(s):  
Takashi MURAMOTO ◽  
Kazuhiro KANEKO ◽  
Kazuo KONISHI ◽  
Hisako NOZAWA ◽  
Atsushi KATAGIRI ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Aldehyde Dehydrogenase ◽  
Squamous Cell ◽  
Gene Polymorphisms ◽  
Precursor Lesions ◽  
Aldehyde Dehydrogenase 2 ◽  
Aldehyde Dehydrogenase 2 Gene

Esophageal Squamous Cell Carcinoma and Aldehyde Dehydrogenase-2 Genotypes in Japanese Females

2006 ◽  
Vol 30 (3) ◽  
pp. 491-500 ◽  
Author(s):  
Akira Yokoyama ◽  
Hoichi Kato ◽  
Tetsuji Yokoyama ◽  
Hiroyasu Igaki ◽  
Toshimasa Tsujinaka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Aldehyde Dehydrogenase ◽  
Squamous Cell ◽  
Aldehyde Dehydrogenase 2

scholarly journals Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chen Niu ◽  
Yong Liu ◽  
Jialin Wang ◽  
Yuqin Liu ◽  
Shaokai Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Intraepithelial Neoplasia ◽  
Precursor Lesions ◽  
Unconditional Logistic Regression ◽  
High Incidence ◽  
History Of

Abstract Background Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed to describe the risk factors associated with ESCC and its precursor lesions. Methods We performed an endoscopic examination of 44,857 individuals aged 40–69 years from five high incidence regions of China in 2017–2018. Participants were classified as 4 groups of normal control, esophagitis, low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia/esophageal squamous cell carcinoma (HGIN/ESCC) using an unconditional logistic regression determine risk factors. Results We identified 4890 esophagitis, 1874 LGIN and 437 HGIN/ESCC cases. Crude odds ratios (ORs) and adjusted odds ratios were calculated using unconditional logistic regression. Drinking well and surface water, salty diet, and positive family history of cancer were the common risk factors for esophagitis, LGIN and HGIN/ESCC. History of chronic hepatitis/cirrhosis was the greatest risk factor of esophagitis (adjusted OR 2.96, 95%CI 2.52–3.47) and HGIN/ESCC (adjusted OR 1.91, 95%CI 1.03–3.22). Pesticide exposure (adjusted OR 1.20, 95%CI 1.05–1.37) was essential risk factor of LGIN. Conclusions Among individuals aged 40–69 years in high incidence regions of upper gastrointestinal cancer, the results provided important epidemiological evidence for the prevention of different precancerous lesions of ESCC.

scholarly journals Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Shih-Wen Lin ◽  
Christian C Abnet ◽  
Neal D Freedman ◽  
Gwen Murphy ◽  
Rosana Risques ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Early Detection ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Telomere Length ◽  
Squamous Cell ◽  
Precursor Lesions

scholarly journals Dietary Patterns and Severity of Symptom with the Risk of Esophageal Squamous Cell Carcinoma and its Histological Precursor Lesions in China: A Multicenter Cross-Sectional Latent Class Analysis

2021 ◽  
Author(s):  
Zhaoping Zang ◽  
Yong Liu ◽  
Jialin Wang ◽  
Yuqin Liu ◽  
Shaokai Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dietary Patterns ◽  
Latent Class ◽  
Esophageal Disease ◽  
Precursor Lesions ◽  
Cross Sectional ◽  
Increased Risk

Abstract Background: Dietary patterns and symptoms research among Chinese with esophageal squamous cell carcinoma (ESCC) and its precursor lesions is limited, especially as it relates to multiple food consumption and multiple co-occurring symptoms. The aim of our study was to identify the dietary patterns and severity of symptom classes with the risk of esophageal squamous cell carcinoma and its histological precursor lesions, and develop a risk prediction model for different stages of esophageal disease.Methods: We analyzed data from a multicenter cross-sectional study carried out in ESCC high incidence areas between 2017 and 2018, which included 34,707 individuals aged 40-69 years. Dietary patterns and severity of symptom classes were derived by applying a latent class analysis (LCA). A multiple logistic regression model was used to derive the odds ratio (ORs) and corresponding 95% confidence intervals (CIs) for ESCC and the different stages of esophageal disease according to the dietary patterns and severity of symptom classes identified. We built the risk prediction model by using a nomogram.Results: We identified five dietary patterns and three severity of symptom classes. The dietary patterns were classified as follows: “Healthy”, “Western”, “Lower consumers-combination”, “Medium consumers-combination” and “Higher consumers-combination” patterns based on the intake of foods such as red meat, vegetables and fruits. The severity of symptoms was categorized into “Asymptomatic”, “Mild symptoms” and “Overt symptoms” classes based on health-related symptoms reported by the participants. Compared to the “Healthy” pattern, the other four patterns were all associated with an increased risk of esophageal disease. Similarly, the other two symptom classes present different degrees of increased risk of esophageal disease compared to the “Asymptomatic”. The nomograms reflect the good predictive ability of the model.Conclusion: Among individuals aged 40-69 years in high incidence regions of upper gastrointestinal cancer, the results supplied important epidemiological evidence and given further insights into dietary patterns and symptoms research.

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