scholarly journals Preparation and Characterization of Electrospun Poly(D,L-lactide-co-glycolide) Scaffolds for Vascular Tissue Engineering and the Advancement of an In Vitro Blood Vessel Mimic

2009 ◽  
Author(s):  
Tiffany Richelle Pena
Keyword(s):  
Tissue Engineering ◽  
Blood Vessel ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering

Surface Modification by Nanobiomaterials for Vascular Tissue Engineering Applications

2020 ◽  
Vol 27 (10) ◽  
pp. 1634-1646 ◽  
Author(s):  
Huey-Shan Hung ◽  
Shan-hui Hsu
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Thrombus Formation ◽  
Vascular Grafts ◽  
Vascular Tissue Engineering ◽  
Great Success ◽  
Natural Polymers ◽  
Vascular Biomaterials

Treatment of cardiovascular disease has achieved great success using artificial implants, particularly synthetic-polymer made grafts. However, thrombus formation and restenosis are the current clinical problems need to be conquered. New biomaterials, modifying the surface of synthetic vascular grafts, have been created to improve long-term patency for the better hemocompatibility. The vascular biomaterials can be fabricated from synthetic or natural polymers for vascular tissue engineering. Stem cells can be seeded by different techniques into tissue-engineered vascular grafts in vitro and implanted in vivo to repair the vascular tissues. To overcome the thrombogenesis and promote the endothelialization effect, vascular biomaterials employing nanotopography are more bio-mimic to the native tissue made and have been engineered by various approaches such as prepared as a simple surface coating on the vascular biomaterials. It has now become an important and interesting field to find novel approaches to better endothelization of vascular biomaterials. In this article, we focus to review the techniques with better potential improving endothelization and summarize for vascular biomaterial application. This review article will enable the development of biomaterials with a high degree of originality, innovative research on novel techniques for surface fabrication for vascular biomaterials application.

Hemocompatibility evaluation of poly(glycerol-sebacate) in vitro for vascular tissue engineering

Biomaterials ◽  
2006 ◽  
Vol 27 (24) ◽  
pp. 4315-4324 ◽  
Author(s):  
Delara Motlagh ◽  
Jian Yang ◽  
Karen Y. Lui ◽  
Antonio R. Webb ◽  
Guillermo A. Ameer
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering

scholarly journals Vascular Tissue Engineering: Recent Advances in Small Diameter Blood Vessel Regeneration

2014 ◽  
Vol 2014 ◽  
pp. 1-27 ◽  
Author(s):  
Valentina Catto ◽  
Silvia Farè ◽  
Giuliano Freddi ◽  
Maria Cristina Tanzi
Keyword(s):  
Tissue Engineering ◽  
Cardiovascular Diseases ◽  
Blood Vessel ◽  
Polyethylene Terephthalate ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Synthetic Polymers ◽  
Vascular Tissue Engineering ◽  
Vessel Regeneration

Cardiovascular diseases are the leading cause of mortality around the globe. The development of a functional and appropriate substitute for small diameter blood vessel replacement is still a challenge to overcome the main drawbacks of autografts and the inadequate performances of synthetic prostheses made of polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE, Goretex). Therefore, vascular tissue engineering has become a promising approach for small diameter blood vessel regeneration as demonstrated by the increasing interest dedicated to this field. This review is focused on the most relevant and recent studies concerning vascular tissue engineering for small diameter blood vessel applications. Specifically, the present work reviews research on the development of tissue-engineered vascular grafts made of decellularized matrices and natural and/or biodegradable synthetic polymers and their realization without scaffold.

Hemocompatibility evaluation of poly(diol citrate)in vitro for vascular tissue engineering

2007 ◽  
Vol 82A (4) ◽  
pp. 907-916 ◽  
Author(s):  
Delara Motlagh ◽  
Josephine Allen ◽  
Ryan Hoshi ◽  
Jian Yang ◽  
Karen Lui ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering

The Effect of Dynamical Strain on the Maturation of Collagen-Based Cell-Containing Scaffolds for Vascular Tissue Engineering

2011 ◽  
Vol 409 ◽  
pp. 152-157 ◽  
Author(s):  
Lucie Levesque ◽  
D. Mantovani
Keyword(s):  
Tissue Engineering ◽  
Smooth Muscle ◽  
Blood Vessel ◽  
Smooth Muscle Cells ◽  
Vascular Tissue ◽  
Muscle Cells ◽  
Collagen Fibrils ◽  
Vascular Tissue Engineering ◽  
Silicone Membrane ◽  
Custom Made

Diseases occurring to blood vessel are preferentially solved by replacing the vessel by an autologous graft. When it is not available, a synthetic graft is used which has low patency rates for small diameter (<6 mm) vessels. Tissue engineering of blood vessel aims to improve the performance of vascular substitutes. Bioreactors are used in vascular tissue engineering to mimic the mechanical and biochemical environment of blood vessel. A 2D bioreactor was custom made in order to impose a dynamical strain to silicone membrane receiving the collagen cell-based construct. Collagen gels with vascular smooth muscle cells cultured inside were subdued to maturation under dynamical uniaxial stretch regimes at 1Hz for 48 hours. The percentage of deformation encountered by the silicone membrane was measured by ImageJ. Collagen fibrils and porcine smooth muscle cells (PSMC) orientations were assessed by scanning electron microscopy (SEM). Results show that the study of mechanical conditioning on cell activity is an important issue for enhancing the alignment of collagen fibrils.

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