scholarly journals The Feasibility and Safety of Early Discharge for Low Risk Patients with Acute Myocardial Infarction after Successful Direct Percutaneous Coronary Intervention.

2003 ◽  
Vol 44 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Hon-Kan Yip ◽  
Chiung-Jen Wu ◽  
Hsueh-Wen Chang ◽  
Chi-Ling Hang ◽  
Chao-Ping Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Coronary Intervention ◽  
Early Discharge ◽  
Low Risk ◽  
Percutaneous Coronary ◽  
Risk Patients

Evaluation of Eptifibatide Treatment in Patients Undergoing Percutaneous Coronary Intervention

2002 ◽  
Vol 18 (6) ◽  
pp. 316-318
Author(s):  
Marwan T Sheikh-Taha ◽  
Warren L Strickland
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Coronary Angioplasty ◽  
Coronary Intervention ◽  
Low Risk ◽  
Minor Bleeding ◽  
Duration Of Treatment ◽  
Percutaneous Coronary ◽  
Risk Patients ◽  
Electrocardiographic Leads

Background: Abrupt closure and restenosis remain serious and costly consequences of coronary angioplasty procedures. Eptifibatide (Integrilin) has been shown to decrease the rate of combined endpoint of death, new myocardial infarction, or the need for urgent intervention in this setting. Platelet aggregation is inhibited by eptifibatide in a dose-dependent manner, with more than 80% receptor occupancy required to prevent thrombus formation. Objective: To evaluate the safety and efficacy of a shorter duration of treatment with eptifibatide in low-risk patients undergoing percutaneous coronary intervention. Methods: We compared low-risk patients undergoing percutaneous coronary intervention who received either conventional eptifibatide dosing or a bolus dose that was sufficient to produce more than 80% platelet inhibition. All patients were followed for major adverse cardiovascular events (MACE) for 90 days after the procedure. MACE complications included death, myocardial infarction (defined as elevation of the creatine kinase-MB fraction at least 3 times the upper limit of normal or new Q-waves in 2 electrocardiographic leads), or any treatment for recurrent angina (percutaneous transluminal coronary angioplasty, stent placement, or coronary artery bypass grafting). Safety was assessed by the incidence of bleeding and thrombocytopenia. Results and Conclusions: None of the patients in either study group had a MACE or thrombocytopenia during the follow-up period. Patients who received a conventional eptifibatide dose had a higher incidence of minor bleeding. It appears that, in low-risk patients, a shorter duration of treatment with eptifibatide may prevent the ischemic complications of percutaneous coronary intervention.

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