scholarly journals Flow-dependent Regulation of Gene Expression in Vascular Endothelial Cells.

1996 ◽  
Vol 37 (1) ◽  
pp. 19-32 ◽  
Author(s):  
Joji ANDO ◽  
Akira KAMIYA
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Regulation Of Gene Expression ◽  
Vascular Endothelial

Epigenetics of the vascular endothelium

2010 ◽  
Vol 109 (3) ◽  
pp. 916-926 ◽  
Author(s):  
Matthew Shu-Ching Yan ◽  
Charles C. Matouk ◽  
Philip A. Marsden
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Posttranslational Modifications ◽  
Cell Biology ◽  
Transcriptional Control ◽  
Vascular Endothelial Cells ◽  
Regulation Of Gene Expression ◽  
Cell Types ◽  
Vascular Endothelial ◽  
Classical Models

Classical models of transcription in vascular endothelial cells, specifically the cis/trans paradigm, have limitations. For instance, how does the environment have chronic effects on gene expression in endothelial cells after weeks or years? When an endothelial cell divides, how is this information transmitted to daughter cells? Epigenetics refers to chromatin-based pathways important in the regulation of gene expression and includes three distinct, but highly interrelated, mechanisms: DNA methylation, histone density and posttranslational modifications, and RNA-based mechanisms. Together they offer a newer perspective on transcriptional control paradigms in vascular endothelial cells and provide a molecular basis for understanding how the environment impacts the genome to modify disease susceptibility. This alternative viewpoint for transcriptional regulation allows a reassessment of the cis/trans model and even helps explain some of its limitations. This review provides an introduction to epigenetic concepts for vascular biologists and uses topical examples in cell biology to provide insight into how cell types or even whole organisms, such as monozygotic human twins with the same DNA sequence, can exhibit heterogeneous patterns of gene expression, phenotype, or diseases prevalence. Using endothelial nitric oxide synthase (NOS3) as an example, we examine the growing body of evidence implicating epigenetic pathways in the control of vascular endothelial gene expression in health and disease.

scholarly journals A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ken’ichiro Hayashi ◽  
Toshiyuki Murai ◽  
Hiroki Oikawa ◽  
Tomoyuki Masuda ◽  
Kazuhiro Kimura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Inhibitory Mechanism

scholarly journals Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells

2020 ◽  
Vol 7 (2) ◽  
pp. 77-83
Author(s):  
Dong-pan Wu ◽  
Tsuyoshi Nakano ◽  
Yayoi Tsuneoka ◽  
Tsutomu Takahashi ◽  
Yo Shinoda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial
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