scholarly journals Effects of Vesnarinone (OPC-8212) on Ca2+-Activated K Channels and Cytosolic Ca2+ in Cultured Smooth Muscle Cells from Porcine Coronary Artery.

1994 ◽  
Vol 35 (1) ◽  
pp. 61-71 ◽  
Author(s):  
Ken SAITO ◽  
Yutaka NAKAYA ◽  
Yukiko MIYOSHI ◽  
Tetsuzo WAKATSUKI ◽  
Masahiro NOMURA ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
K Channels ◽  
Porcine Coronary Artery ◽  
Cultured Smooth Muscle Cells

scholarly journals Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery.

1992 ◽  
Vol 70 (3) ◽  
pp. 612-616 ◽  
Author(s):  
Y Miyoshi ◽  
Y Nakaya ◽  
T Wakatsuki ◽  
S Nakaya ◽  
K Fujino ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
K Channels ◽  
Porcine Coronary Artery

scholarly journals Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery

1992 ◽  
Vol 58 ◽  
pp. 338
Author(s):  
Y. Miyoshi ◽  
T. Wakatsuki ◽  
M. Nomura ◽  
K. Saito ◽  
Y. Nakaya ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
K Channels ◽  
Porcine Coronary Artery

Vasopressin modulates K(+)-channel activities of cultured smooth muscle cells from porcine coronary artery

1992 ◽  
Vol 263 (2) ◽  
pp. H491-H496 ◽  
Author(s):  
T. Wakatsuki ◽  
Y. Nakaya ◽  
I. Inoue
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cells ◽  
Katp Channel ◽  
Muscle Cells ◽  
K Channel ◽  
Resting Membrane Potential ◽  
Dependent Manner ◽  
Porcine Coronary Artery ◽  
Cultured Smooth Muscle Cells

The ATP-sensitive K+ channel (KATP channel) and the Ca(2+)-activated K+ channel (KCa channel) were active in cell-attached and excised inside-out patch configurations in cultured smooth muscle cells of the porcine coronary artery. Vasopressin activated the KCa channel (240 pS) when it was applied in the bath in the cell-attached patch mode presumably because of an increase in intracellular Ca2+, but it had no direct effect on the KCa channel. However, vasopressin directly blocked the KATP channel from outside the cell membranes in a concentration-dependent manner in both outside-out and cell-attached patch configurations; the K(+)-channel opener, nicorandil, reversed this effect. The KATP channel (30 pS) was highly active in the intact cell-attached patch configuration when the pipette contained a physiological concentration of Ca2+, suggesting that this channel may control the resting membrane potential. (The block might produce depolarization of the cells and might result in the contraction of smooth muscle cells.) These observations suggest that the KATP channel may play a role, at least in part, in controlling the contraction of smooth muscle cells of the coronary artery and that the control of vascular tone by vasopressin may be related to its ability to block the KATP channel.

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