scholarly journals Comparison of Vascular Lesions among Various Tissues of Spontaneously Hypertensive Rats

1994 ◽  
Vol 35 (4) ◽  
pp. 574-574
Author(s):  
Noboru Saito ◽  
Teruhiko Okada ◽  
Masatoshi Shirota ◽  
Shoji Nishiyama
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Vascular Lesions ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Studies on Hypertension in Spontaneously Hypertensive Rats

1973 ◽  
Vol 45 (s1) ◽  
pp. 11s-14s
Author(s):  
Kozo Okamoto ◽  
Yukio Yamori ◽  
Shoichiro Nosaka ◽  
Akira Ooshima ◽  
Fumitada Hazama
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Genetic Factors ◽  
Vascular Lesions ◽  
Hypertensive Rats ◽  
Cerebrovascular Lesions ◽  
Spontaneously Hypertensive

1. The pathogenesis and complications occurring in spontaneously hypertensive rats (SHR) have been studied. 2. Genetic factors are important both in the development of hypertension and in determining susceptibility to vascular lesions. 3. Selective substrains of SHR may be particularly prone to develop cerebrovascular lesions.

scholarly journals Effect of salt on the vascular lesions of spontaneously hypertensive rats.

Hypertension ◽  
1980 ◽  
Vol 2 (4) ◽  
pp. 477-489 ◽  
Author(s):  
C Limas ◽  
B Westrum ◽  
C J Limas ◽  
J N Cohn
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Vascular Lesions ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Vascular Lesions Produced by Renal Cortical Extracts of Spontaneously Hypertensive Rats (SHR)

1978 ◽  
Vol 19 (4) ◽  
pp. 659-659
Author(s):  
Issei NISHIMORI ◽  
Naotaka MIYAGAWA ◽  
Junichi MIYAZAKI ◽  
Toshihiro TAKAGI
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Vascular Lesions ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals VASCULAR LESIONS IN THE VARIOUS SUBSTRAINS OF SPONTANEOUSLY HYPERTENSIVE RATS AND THE EFFECTS OF CHRONIC SALT INGESTION

1975 ◽  
Vol 39 (1) ◽  
pp. 7-22 ◽  
Author(s):  
FUMITADA HAZAMA ◽  
AKIRA OOSHIMA ◽  
TOSHINARI TANAKA ◽  
KAZUHIKO TOMIMOTO ◽  
KOZO OKAMOTO
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Vascular Lesions ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Candesartan prevents L-NAME-induced cardio-renal injury in spontaneously hypertensive rats beyond hypotensive effects

2001 ◽  
Vol 2 (1_suppl) ◽  
pp. S84-S90 ◽  
Author(s):  
Daniel Casellas ◽  
Abderraouf Herizi ◽  
Annie Artuso ◽  
Albert Mimran ◽  
Bernard Jover
Keyword(s):  
Angiotensin Ii ◽  
Cardiac Hypertrophy ◽  
Renal Injury ◽  
Spontaneously Hypertensive Rats ◽  
Candesartan Cilexetil ◽  
Vascular Lesions ◽  
Heart Weight ◽  
Hypertensive Rats ◽  
Renal Protection ◽  
Spontaneously Hypertensive

Our goal was to assess the cardiovascular and renal protection afforded by angiotensin II type 1-receptor blockade against NG-nitro-L-arginine methyl ester (L-NAME)-exacerbated hypertension in young spontaneously hypertensive rats (SHR), in comparison with the antihypertensive drug, hydralazine. Male SHR were assigned to four groups (n=8 per group): no treatment (controls); L-NAME-treated group (20 mg/kg/day, 10 days, orally); co-treatment with L-NAME and hydralazine (15 mg/kg/day, by gavage); co-treatment with L-NAME and candesartan cilexetil (10 mg/kg/day, by gavage), i.e. at a dose that inhibited acute pressor responses to 5—20 ng angiotensin II. One animal died in the L-NAME group, and tail-cuff systolic blood pressure (SBP) increased significantly compared with controls to 201±5 mmHg. Albumin excretion increased 235-fold in L-NAME-treated rats. Heart weight index averaged 3.5±0.1 and 3.8±0.1 mg/g body weight (p<0.05) in control and L-NAME rats, respectively, indicating moderate cardiac hypertrophy induced by L-NAME. Preglomerular vascular lesions affected 63±6% of interlobular arteries and 10±2% of afferent arterioles (vs. 8±3 and 0.8±0.4% in controls, respectively). Hydralazine and candesartan cilexetil treatment similarly reduced SBP to 153±7, and 165±6 mmHg, respectively. However, candesartan provided more protection, in terms of no significant change in albuminuria (vs. 25-fold increase with hydralazine), regression of cardiac hypertrophy, frequency of vascular lesions and histological indices of renal injury maintained within control values. In conclusion, candesartan cilexetil prevented L-NAME-exacerbated hypertension and associated cardio-renal injury in young SHR, the beneficial effects exceeding those of hydralazine.

The Thymus of Spontaneously Hypertensive Rats: Light- and Electron-Microscopic Studies

1973 ◽  
Vol 45 (s1) ◽  
pp. 141s-144s
Author(s):  
J. M. Rojo-Ortega ◽  
E. Yeghiayan ◽  
J. Genest
Keyword(s):  
Epithelial Cells ◽  
Vascular Disease ◽  
Spontaneously Hypertensive Rats ◽  
Plasma Cells ◽  
Vascular Lesions ◽  
Hypertensive Rats ◽  
Electron Microscopic ◽  
Spontaneously Hypertensive ◽  
Microscopic Studies ◽  
Microscopic Techniques

1. The present investigation was undertaken to study the possibility that hypertensive vascular disease could be associated with changes in the morphology of the thymus. 2. Using light- and electron-microscopic techniques, the thymus of spontaneously hypertensive rats (SHR) with (1 year of age) and without (10 weeks of age) severe vascular lesions were compared with appropriate controls. 3. The thymus of SHR with severe hypertensive vascular disease showed: (a) marked hyperplasia and hypertrophy of the epithelial cells, with ultrastructural features of hypersecretory activity, and (b) in contrast to the paucity of plasma cells in the thymus of the control animals, the SHR had numerous plasma cells. 4. These observations may suggest the involvement of an autoimmunological mechanism in the development of the vascular lesions in SHR.

Sign in / Sign up

Export Citation Format

Share Document