scholarly journals Effect of sodium intake on the brain and the aortic angiotensin-converting enzyme activity in spontaneously hypertensive rat.

1981 ◽  
Vol 22 (5) ◽  
pp. 839-845 ◽  
Author(s):  
Kenji MIZUNO ◽  
Shyuichi SHIGETOMI ◽  
Junichiro MATSUI ◽  
Soitsu FUKUCHI
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rat ◽  
Sodium Intake ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Activity ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
The Brain

Effect of Sodium Intake on Angiotensin-Converting Enzyme Activity of Aorta in Rats

1981 ◽  
Vol 61 (2) ◽  
pp. 249-251 ◽  
Author(s):  
Kenji Mizuno ◽  
Shunichi Hata ◽  
Soitsu Fukuchi
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Sodium Intake ◽  
Subcellular Fractions ◽  
Supernatant Fraction ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Angiotensin Converting Enzyme Activity ◽  
Spontaneously Hypertensive

1. The effect of sodium intake on angiotensin-converting enzyme activity in subcellular fractions of aorta (homogenate, mitochondria, microsomes and supernatant) was studied in normotensive and spontaneously hypertensive rats. 2. Angiotensin-converting enzyme activity was extremely high in the supernatant fraction in normotensive and spontaneously hypertensive rats. 3. Total converting enzyme activity in spontaneously hypertensive rats was 34% higher than that in normotensive rats. 4. Increased sodium intake resulted in a marked reduction, almost to zero, of converting enzyme activity in each fraction of aorta in normotensive and spontaneously hypertensive rats. 5. Converting enzyme, widely distributed in subcellular fractions of the aorta, may play a possible rôle in the local control of vascular tone. It is likely that sodium intake inhibits production of the enzyme in vascular tissue.

Renoprotective Differences between Perindopril and Enalapril in the Diabetic Hypertensive Rat Do Not Reflect Glomerular Angiotensin-Converting Enzyme Activity

1998 ◽  
Vol 94 (5) ◽  
pp. 511-516 ◽  
Author(s):  
K. A. Duggan ◽  
G. Hodge ◽  
M. M. Makarious ◽  
J. A. Charlesworth
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Protein Content ◽  
Protein Accumulation ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Activity ◽  
Spontaneous Hypertensive Rat ◽  
Hypertensive Rat ◽  
Plasma Angiotensin ◽  
Plasma Angiotensin Converting Enzyme

1. The various angiotensin-converting enzyme inhibitors have structural differences which affect their affinities for the catalytic sites on converting enzyme. We postulated that such differences might result in differences in renoprotective efficacy. We investigated this in the diabetic spontaneous hypertensive rat. We also investigated whether these differences might reflect variations in glomerular or plasma angiotensin-converting enzyme activity. 2. One week after induction of diabetes, rats were started on antihypertensive therapy: enalapril, 10 mg · day−1 · kg−1, or perindopril, 4 mg · day−1 · kg−1, in the drinking water. After 3 months, the rats were killed, blood samples were taken and tissues were harvested. Angiotensin-converting enzyme activity in isolated glomeruli and plasma was measured by fluorimetric assay. Glomerular protein content was also determined. 3. Urinary protein excretion was significantly lower in perindopril-treated rats than in either controls (P < 0.0005) or enalapril-treated rats P < 0.05). Glomerular protein content was also lower in perindopril-treated rats (P < 0.05 versus enalapril; P < 0.005 versus control). There was no difference in glomerular angiotensin-converting enzyme activity between the two inhibitors although both were lower than control values (enalapril P < 0.025; perindopril P < 0.025). Plasma angiotensin-converting enzyme activity was significantly lower in the perindopril group than in either control (P < 0.005) or the enalapril group (P < 0.01). 4. We conclude that in the spontaneous hypertensive rat with streptozotocin-induced diabetes, perindopril is more effective than enalapril in reducing proteinuria and glomerular protein accumulation. This difference does not result from differences in glomerular-converting enzyme activity.

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