scholarly journals Effects of Beta-Adrenergic Blocking Agents on the Blood Pressure, Plasma Renin Activity and Hemodynamics of Hypertensive Patients

1977 ◽  
Vol 18 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Masato MATSUNAGA ◽  
Akira HARA ◽  
Koichi OGINO ◽  
Seiichiro MOTOHARA ◽  
Muneyasu SAITO ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Beta Adrenergic ◽  
Hypertensive Patients ◽  
Blocking Agents ◽  
Pressure Plasma ◽  
Adrenergic Blocking ◽  
Beta Adrenergic Blocking Agents

Renin-Suppressive Potency of Various Beta-Adrenergic Blocking Agents at Supine Rest and during Upright Exercise

1974 ◽  
Vol 48 (s2) ◽  
pp. 61s-64s ◽  
Author(s):  
F. R. Bühler ◽  
G. Marbet ◽  
U. Patel ◽  
F. Burkart
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Beta Adrenergic ◽  
Blocking Agents ◽  
Beta Blocking ◽  
Different Types ◽  
Adrenergic Blocking ◽  
Beta Adrenergic Blocking Agents ◽  
Adrenergic Blocking Agents

1. Renin responses to different types of beta-adrenergic blocking agents were compared in eight normal volunteers at supine rest and during moderate upright exercise. 2. Comparable beta-adrenergic blockade was achieved with equipotent cardiodeceleratory doses of 100 mg of propranolol, 400 mg of practolol, 100 mg of oxprenolol, 10 mg of timolol, 5 mg of pindolol or 100 mg of ICI 66082. 3. All beta-blocking agents tested significantly and markedly reduced plasma renin activity during upright exercise. Renin suppression was not related to either β1- or β2-type receptor blocking action. 4. Renin levels at rest were generally reduced by the blocking drugs, but these responses did not reach significance for oxprenolol and pindolol. With both these drugs, lesser suppressibility of basal renin may be due to their inherent sympathomimetic activity. 5. The results suggest that different types of beta-blocking agents suppress plasma renin activity and therefore that they all may lower blood pressure through reduction of angiotensin vasoconstriction.

Effect of Pindolol on Blood Pressure, Plasma Renin Activity, and Catecholamines in Hypertensive Patients

1981 ◽  
Vol 21 (2-3) ◽  
pp. 79-83 ◽  
Author(s):  
IRENE GAVRAS ◽  
HARALAMBOS GAVRAS ◽  
CHARLES P. TIFFT ◽  
GLENN R. KERSHAW ◽  
MARGARET BRESNAHAN
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Hypertensive Patients ◽  
Pressure Plasma

Alcohol Withdrawal and Hypertension: Evidence for a Kidney Abnormality

1985 ◽  
Vol 69 (2) ◽  
pp. 239-240 ◽  
Author(s):  
Sergio De Marchi ◽  
Emanuela Cecchin
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Alcohol Withdrawal ◽  
Plasma Renin ◽  
Renin Activity ◽  
Withdrawal Symptoms ◽  
Pressure Plasma ◽  
High Prevalence ◽  
Blood Pressures

We are very interested to read the paper by Bannan et al. [1] about the effect of alcohol withdrawal on blood pressure, plasma renin activity, aldosterone, cortisol and dopamine β-hydroxylase. It has been known for several years that alcoholic patients admitted to hospital for detoxification have a high prevalence of hypertension [2]. Their blood pressures return to normal after alcohol withdrawal symptoms have abated and they remain normal if they continue to abstain. Patients who resume drinking sustain a rise in blood pressure to their former high levels.

Sodium and Renin in the Hypertension of Early Renal Disease

1978 ◽  
Vol 55 (s4) ◽  
pp. 301s-303s ◽  
Author(s):  
S. F. Wong ◽  
M. I. Mitchell ◽  
V. Robson ◽  
R. Wilkinson
Keyword(s):  
Blood Pressure ◽  
Renal Disease ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Exchangeable Sodium ◽  
Hypertensive Patients ◽  
Body Build ◽  
Activity Response ◽  
Normal Controls

1. Plasma renin activity, response to saralasin and exchangeable sodium have been measured in 43 patients with early renal disease. 2. Blood pressure was directly proportional to plasma renin activity. However, mean plasma renin activity was lower in patients with renal disease than in normal controls. 3. Blood pressure fell in response to saralasin infusion in proportion to the pre-infusion plasma renin activity. 4. Exchangeable sodium in hypertensive patients with renal disease did not exceed that in normotensive patients in contrast to earlier reports. Discrepancies may arise from the difficulty in interpreting measured exchangeable sodium in relation to body build.

Plasma Renin in Long-Term Diuretic Treatment of Hypertension: Effect of Discontinuation and Restarting Therapy

1982 ◽  
Vol 63 (2) ◽  
pp. 121-125 ◽  
Author(s):  
S. Swart ◽  
R. F. Bing ◽  
J. D. Swales ◽  
H. Thurston
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Juxtaglomerular Apparatus ◽  
Significant Rise ◽  
Renin Activity ◽  
Hypertensive Patients ◽  
Diuretic Treatment ◽  
Low Renin Hypertension ◽  
Before And After

1. Plasma renin activity, body weight and blood pressure were measured before and after 7 days' treatment with bendrofluazide in ten hypertensive subjects. They were then treated with bendrofluazide alone (5 mg daily) for a minimum of 3 years. The diuretic was then discontinued and the measurements were repeated before and again after 7 days with bendrofluazide. The results were compared with those obtained before chronic treatment with the diuretic. 2. Chronic diuretic treatment was associated with a persistent and progressive rise in plasma renin activity, that fell promptly to pretreatment levels when diuretics were discontinued. This was associated with significant weight gain but no immediate significant rise in blood pressure. 3. When acutely challenged with bendrofluazide the patients showed a greater increase in plasma renin activity on the second occasion than on the first. Three out of five patients with an initially subnormal response had normal responses after chronic diuretic treatment. 4. Chronic diuretic treatment increased the responsiveness of the juxtaglomerular apparatus in some hypertensive patients. 5. Classification of hypertensive patients into renin subgroups may be influenced by previous therapy, even when that therapy has been discontinued for 4 weeks. In particular ‘low renin hypertension’ may be masked by recent use of diuretics, as shown by three of the five patients in this subgroup in the present study.

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