scholarly journals Effects of β-Blocker (Propranolol) on the Blood Pressure, Heart Weight and Heart Rate of Spontaneously Hypertensive Rat Fed with High-Salt, High-Carbohydrate, and Low-Protein Diet

1975 ◽  
Vol 16 (3) ◽  
pp. 340-341
Author(s):  
Hideo UEDA ◽  
Atsushi SAKAMOTO ◽  
Haruo KOBAYASHI ◽  
Katsumi KANEKO ◽  
Yoshio SUGANUMA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spontaneously Hypertensive Rat ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Heart Weight ◽  
Spontaneously Hypertensive ◽  
High Carbohydrate ◽  
Low Protein ◽  
Β Blocker

Effect of High-Salt, High-Carbohydrate, Low-Protein Diet on Hypertension in the Rat

1973 ◽  
Vol 45 (s1) ◽  
pp. 99s-102s
Author(s):  
Hideo Ueda
Keyword(s):  
Blood Pressure ◽  
High Protein Diet ◽  
Normal Diet ◽  
High Salt ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Heart Weight ◽  
Hypertensive Rats ◽  
High Carbohydrate ◽  
Low Protein

1. High-salt, high-carbohydrate and low-protein diet induces remarkable elevation of blood pressure in spontaneous hypertensive rats (SHR). 2. These animals have low serum potassium, low blood urea nitrogen and high blood sugar. 3. Heart weight is increased in proportion to the elevation of blood pressure. 4. Kidney weight of rats receiving the high-salt, high-carbohydrate and low-protein diet was, by contrast, smaller than SHR receiving a normal diet. 5. The kidneys of SHR receiving a high-salt, high-protein diet were twice as heavy as the kidneys of normal rats. 6. Similar dietary modifications in Goldblatt hypertensive rats to those in SHR produced similar changes in blood pressure and heart weight.

Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL

2002 ◽  
Vol 10 (3) ◽  
pp. 199-210 ◽  
Author(s):  
Adamu Alemayehu ◽  
Laura Breen ◽  
Drahomira Krenova ◽  
Morton P. Printz
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spontaneously Hypertensive Rat ◽  
Cardiovascular Responses ◽  
Chromosome 2 ◽  
Spontaneously Hypertensive ◽  
Congenic Strains ◽  
Multiple Blood ◽  
Wistar Kyoto ◽  
Chromosome Segments

Evidence exists implying multiple blood pressure quantitative trait loci (QTL) on rat chromosome 2. To examine this possibility, four congenic strains and nine substrains were developed with varying size chromosome segments introgressed from the spontaneously hypertensive rat (SHR/lj) and normotensive Wistar-Kyoto rat (WKY/lj) onto the reciprocal genetic background. Cardiovascular phenotyping was conducted with telemetry over extended periods during standard salt (0.7%) and high-salt (8%) diets. Our results are consistent with at least three independent pressor QTL: transfer of SHR/lj alleles to WKY/lj reveals pressor QTL within D2Rat21-D2Rat27 and D2Mgh10-D2Rat62, whereas transfer of WKY/lj D2Rat161-D2Mit8 to SHR/lj reveals a depressor locus. Our results also suggest a depressor QTL in SHR/lj located within D2Rat161-D2Mgh10. Introgressed WKY/lj segments also reveal a heart rate QTL within D2Rat40-D2Rat50 which abolished salt-induced bradycardia, dependent upon adjoining SHR/lj alleles. This study confirms the presence of multiple blood pressure QTL on chromosome 2. Taken together with our other studies, we conclude that rat chromosome 2 is rich in alleles for cardiovascular and behavioral traits and for coordinated coupling between behavior and cardiovascular responses.

scholarly journals Very low protein diet supplemented with ketoanalogs improves blood pressure control in chronic kidney disease

2007 ◽  
Vol 71 (3) ◽  
pp. 245-251 ◽  
Author(s):  
V. Bellizzi ◽  
B.R. Di Iorio ◽  
L. De Nicola ◽  
R. Minutolo ◽  
P. Zamboli ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Very Low Protein Diet

DOMINANT EFFECT OF SUPPLEMENTED-SUCROSE ON THE LOW PROTEIN DIET-INDUCED INCREASE IN BLOOD PRESSURE OF SPRAGUE-DAWLEY RATS

2001 ◽  
Vol 23 (7) ◽  
pp. 569-578
Author(s):  
Michiyo Endoh ◽  
Asako Kunieda ◽  
Takashi Yoneyama ◽  
Kazuhisa Ohishi ◽  
Akira Hishida ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Sprague Dawley ◽  
Dominant Effect ◽  
Low Protein ◽  
Sprague Dawley Rats

Weanling Rats Exposed to Maternal Low-Protein Diets during Discrete Periods of Gestation Exhibit Differing Severity of Hypertension

1996 ◽  
Vol 91 (5) ◽  
pp. 607-615 ◽  
Author(s):  
Simon C. Langley-Evans ◽  
Simon J. M. Welham ◽  
Rachel C. Sherman ◽  
Alan A. Jackson
Keyword(s):  
Blood Pressure ◽  
Control Diet ◽  
Plasma Renin ◽  
Late Gestation ◽  
Protein Diet ◽  
Male Rats ◽  
Low Protein Diet ◽  
Fetal Exposure ◽  
Low Protein ◽  
Protein Diets

1. In the rat, hypertension is induced by fetal exposure to maternal low-protein diets. The effect on blood pressure of undernutrition before conception and during discrete periods in early, mid or late pregnancy was assessed using an 18% casein (control) diet and a 9% casein diet to apply mild protein restriction. 2. The offspring of rats fed 9% casein developed raised blood pressure by weaning age. Feeding a low-protein diet before conception was not a prerequisite for programming of hypertension. 3. Hypertension was observed in rats exposed to low protein during the following gestational periods: days 0–7, days 8–14 and days 15–22. Blood pressure increases elicited by these discrete periods of undernutrition were lower than those induced by feeding a low-protein diet throughout pregnancy. The effect in early gestation was significant only in male animals. Post-natal growth of male rats exposed to low-protein diets was accelerated, but kidneys were small in relation to body weight. 4. Biochemical indices of glucocorticoid action in liver, hippocampus, hypothalamus and lung were elevated in rats exposed to low-protein diets in utero. The apparent hypersensitivity to glucocorticoids was primarily associated with undernutrition in mid to late gestation. 5. Plasma renin activity was elevated in rats exposed to 9% casein over days 15–22 of gestation. Animals undernourished over days 0–7 and 8–14 produced pups with lower plasma angiotensin II concentrations at weaning. 6. Fetal exposure to maternal low-protein diets for any period in gestation may programme hypertension in the rat. Alterations to renal structure, renal hormone action or the hypothalamic—pituitary-adrenal axis may all play a role in the programming phenomenon, either independently or in concert.

scholarly journals BIOCHEMICAL EFFECT OF A HIGH DOSE OF THAUMATIN IN WISTAR RATS

2016 ◽  
Vol 9 (1) ◽  
pp. 304
Author(s):  
Warid Khayata ◽  
Ahmad Kamri ◽  
Rasha Alsaleh
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Total Protein ◽  
Wistar Rats ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Oral Glucose ◽  
High Dose ◽  
High Carbohydrate ◽  
Low Protein

<p><strong>Objective: </strong>The aim of this work was to investigate the capability of a high dose of thaumatin; a sweet tasting protein, of improving induced protein malnutrition in male Wistar rats.</p><p><strong>Methods: </strong>For this study, 12 rats were divided into 2 groups and treated orally along with a high-carbohydrate, low-protein diet as follows: water group as a negative control, and thaumatin group at a dose of 464 mg/kg for 3 consecutive w. Blood samples were collected to analyse glucose, triglycerides, total cholesterol, and total protein, and body weight was measured. An oral glucose tolerance test (OGTT) was carried out at the end of the experiment.</p><p><strong>Results: </strong>Despite the high amount of<strong> </strong>thaumatin used, only a slight increase in blood glucose occurred and was within the normal range, whereas serum triglycerides and cholesterol decreased significantly unlike control. Body weight had declined in both groups due to a low-protein diet, while total protein and glucose tolerance remained unchanged.</p><strong>Conclusion: </strong>It is found that<strong> </strong>thaumatin is safe to consume by Wistar rats even at high doses. Besides that high-carbohydrate, low-protein diet caused falling of body weight, it had drawbacks of increased triglycerides and cholesterol levels which can be useful to create animal models of abnormal lipid metabolism without obesity. However, simultaneous ingestion of thaumatin with this diet had altered the outcomes to the best case. In future, it may be possible to use this combination for achieving healthy eating patterns without drug intervention that is needed for obese patients with various dysglycemia or dyslipidemia manifestations and people following regimes for weight reduction.<p> </p>

scholarly journals Chemical Characterisation and Antihypertensive Effects of Locular Gel and Serum of Lycopersicum esculentum L. var. “Camone” Tomato in Spontaneously Hypertensive Rats

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3758 ◽  
Author(s):  
Paola Marcolongo ◽  
Alessandra Gamberucci ◽  
Gabriella Tamasi ◽  
Alessio Pardini ◽  
Claudia Bonechi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spontaneously Hypertensive Rats ◽  
Pressure Control ◽  
Heart Weight ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Industrial Processing ◽  
Blood Cytokines

Blood pressure control in hypertensive subjects calls for changes in lifestyle, especially diet. Tomato is widely consumed and rich in healthy components (i.e., carotenoids, vitamins and polyphenols). The aim of this study was to evaluate the chemical composition and antihypertensive effects of locular gel reconstituted in serum of green tomatoes of “Camone” variety. Tomato serum and locular gel were chemically characterised. The antihypertensive effects of the locular gel in serum, pure tomatine, and captopril, administered by oral gavage, were investigated for 4 weeks in male spontaneously hypertensive and normotensive rats. Systolic blood pressure and heart rate were monitored using the tail cuff method. Body and heart weight, serum glucose, triglycerides and inflammatory cytokines, aorta thickness and liver metabolising activity were also assessed. Locular gel and serum showed good tomatine and polyphenols content. Significant reductions in blood pressure and heart rate, as well as in inflammatory blood cytokines and aorta thickness, were observed in spontaneously hypertensive rats treated both with locular gel in serum and captopril. No significant effects were observed in normotensive rats. Green tomatoes locular gel and serum, usually discarded during tomato industrial processing, are rich in bioactive compounds (i.e., chlorogenic acid, caffeic acid and rutin, as well as the glycoalkaloids, α-tomatine and dehydrotomatine) that can lower in vivo blood pressure towards healthier values, as observed in spontaneously hypertensive rats.

scholarly journals Changes in amino acid profiles and liver alterations in pregnant rats with a high carbohydrate/low protein diet

2019 ◽  
Vol 18 (2) ◽  
pp. 345-353
Author(s):  
Mónica Navarro-Meza ◽  
Ana B. Cardador-Martínez ◽  
Olivia Vazquez-Martínez ◽  
José A. Cruz-Ramos ◽  
Felipe Santoyo-Telles ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Pregnant Rats ◽  
High Carbohydrate ◽  
Low Protein ◽  
Amino Acid Profiles
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