scholarly journals Clinical Manifestations of Symptomatic COVID-19 Patients in Kabul Province, the Capital of Afghanistan

2020 ◽  
Vol 7 ◽  
Author(s):  
Hashmatullah Yousufi ◽  
Ahmad Zia Noori ◽  
Shoaib Naeemi ◽  
Hamidullah Rasekh ◽  
Muzhda Haem Rahimi ◽  
...  
Keyword(s):  
Sore Throat ◽  
Clinical Presentation ◽  
Standard Form ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Young Generation ◽  
Cross Sectional ◽  
Oropharyngeal Swab ◽  
The Mean

Background: SARS-CoV-2 is a novel member of human coronavirus that is newly identified in Wuhan, Hubei, China. The COVID-19 pandemic has spread to over 213 countries and affected more than 33 million individuals and caused 999000 deaths worldwide.Methods: This cross-sectional study conducted on 124 symptomatic COVID-19 patients in Kabul, Afghanistan. Demographic and clinical data collected using a standard form.  Nasopharyngeal/oropharyngeal swab sample collected for viral detection. Data were analyzed using IBM SPSS statistics (version 21) software.Results: Out of 124 patients, 88 (71%) were male and 36 (29%) were female. The mean age of patients was 41.2±17.07 years and the majority of patients 32 (25.8%) were in the age group of 20 – 29 and minority 3 (2.4) was over 79 years. On clinical presentation, most patients had ageusia (71.3%), fever (69.4%), headache (69.4%), sore throat (66.1%), myalgia (66.1%), cough (64.5%), weakness (63.7%), dyspnea (38.7%), and the fewer symptom was diarrhea (31.5%). 19 (15.3%) patients had Hypertension, 16 (12.9%) had cardiovascular disease, 8 (6.5%) had diabetes, 5 (4.0%) had cancer, 4 (3.2%) had chronic pulmonary disease, and 3 (2.4%) had liver disease. The mean duration for the presence of symptoms was 13.3±6.3 days. The fatality rate was 4%.Conclusion: Our study reveals that males are more affected by COVID-19 than females and the young generation is more affected than elders.  The most common symptoms are ageusia, fever, headache, sore throat, and myalgia, and the less common symptom is diarrhea.

scholarly journals Time Intervals From Onset of Clinical Manifestations to Treatment in Patients With Cancer at Hospital General San Felipe, Tegucigalpa, Honduras

2019 ◽  
pp. 1-7
Author(s):  
José A. Sánchez ◽  
Mayra G. Handal ◽  
Juan F. Vílchez Rodriguez ◽  
Sinthia I. Mejía ◽  
Annye P. Pagoaga
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Clinical Staging ◽  
Time Interval ◽  
Pathology Report ◽  
Time Intervals ◽  
Cross Sectional ◽  
Patients With Cancer ◽  
The Mean ◽  
Mean Time

PURPOSE In cancer, clinical staging is related to outcomes, and this is linked to the evolution of the disease over time. In Honduras, cancer mortality is high, and time intervals from onset of symptoms to treatment of cancer are not known. We conducted a cross-sectional study to determine these intervals. PATIENTS AND METHODS This investigation was carried out from April 25 to August 30, 2018, and included 202 patients at the main cancer referral center in Honduras. For the purposes of the study, information was obtained from patients, their caregiver, medical records, or treatment cards. Patients older than age 18 years were included after informed consent was signed. RESULTS The mean time interval from onset of symptoms to cancer treatment was 232 days. Different intervals of time were identified, and the mean of these intervals was calculated in days as follows: 68 days from onset of symptoms to first medical evaluation; 146 days from first evaluation to oncologist consultation; 26 days from cancer specialist to the pathology report; and 86 days from the histopathologic diagnosis to the beginning of treatment. Once diagnosis was established, the average elapsed times to chemotherapy, radiotherapy, surgery, and chemoradiotherapy were 88, 102, 76, and 154 days, respectively ( P < .05, when surgery is compared against chemotherapy and radiotherapy). CONCLUSION The mean time interval from symptom presentation to treatment in patients with cancer is more than 7 months. This could explain the advanced stages of disease seen at the time of treatment in Honduras, which decrease chance of cure and increase the mortality rate of cancer). Appropriate intervention to decrease these intervals must be taken to reduce mortality.

scholarly journals VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS

2021 ◽  
Vol 71 (5) ◽  
pp. 1839-43
Author(s):  
Areeba Wasim ◽  
Javeria Raza Alvi ◽  
Natasha Ghani ◽  
Athar Khalily ◽  
Zia Ur Rehman ◽  
...  
Keyword(s):  
Early Onset ◽  
Clinical Presentation ◽  
Subacute Sclerosing Panencephalitis ◽  
Intractable Epilepsy ◽  
Cross Sectional Study ◽  
P Value ◽  
Atypical Presentation ◽  
Cross Sectional ◽  
Younger Age ◽  
The Mean

Objective: To determine the variations in clinical presentation, neuroimaging and electroencephalography patterns of subacute sclerosing panencephalitis. Study Design: Cross-sectional study. Place and Duration of Study: Children’s Hospital & Institute of Child Health, Lahore, Pakistan, from Jul to Dec 2020. Methodology: We recruited children presented with clinical features suggestive of subacute sclerosing panencephalitis, along with positive anti-measles antibodies on cerebrospinal fluid. Association between variables was determined to formulate an early diagnosis of subacute sclerosing panencephalitis. Results: Out of 47 children, 29 were males with a mean age of 6.54 ± 2.9 years. Only 23% were fully immunized against measles, 36.2% were unvaccinated and 40.4% received partial immunization. The mean age of measles infection was 1.49 ± 1.2 years; the mean interval between measles and onset of SSPE was 4.13 ± 3 years. Atypical clinical presentation was seen in 38.3% with intractable epilepsy (8.5%), focal deficit (8.5%) and extrapyramidal symptoms (8.5%) being commonest followed by coma (6.4%), visual loss (4.3%) and psychosis (2.1%). Neuroimaging was suggestive of cortical hyperintensities in 46.8% and was normal in 46.8%. Electroencephalography showed burst suppression in 55.3% and atypical findings in 19.1%. Younger age (1-1.5 years) of measles and unimmunized status were associated with early onset of SSPE with a p-value of 0.001 and 0.05 respectively. Non-immunized status was associated with atypical presentation of SSPE (p-value <0.05). Conclusion: The younger age of measles infection and failure to receive complete immunization led to early onset of Subacute sclerosing panencephalitis with an atypical presentation.

scholarly journals Clinical Presentation of Primary Hyperparathyroidism in Lahore, Pakistan – A Single Center Study

2021 ◽  
Vol 5 (5) ◽  
pp. 01-03
Author(s):  
Rizwan Khalid ◽  
Muhammad Hassaan ◽  
Ali Raza
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Presentation ◽  
Renal Involvement ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Screening Tests ◽  
Cross Sectional ◽  
Wide Range ◽  
Common Clinical Presentation ◽  
Time Of Presentation

Aim: To assess different clinical presentations and outcomes of primary hyperparathyroidism in Pakistan. Study Design: Retrospective cross-sectional study. Study Setting: East Surgical Ward, Mayo Hospital, Lahore. Duration: 2011 to 2016 Introduction: PHPT is a common endocrine condition with a wide range of clinical manifestations differing according to geographic. Discussion: The most common clinical presentation in our study was bone pains which were in contrast to the asymptomatic cases being most common manifestation in US and Western countries. 90% (n 36) of the patients had bony involvement while 47.5% (n 19) had renal involvement at the time of presentation. Conclusion: Due to lack of routine biochemical screening tests in developing countries, primary hyperparathyroidism is detected late.

scholarly journals Clinical Characteristics and main presentation of the COVID19 among Iraqi people

2020 ◽  
Vol 04 (2) ◽  
pp. 50-58
Author(s):  
Mohammed Ibraheem ◽  
Sarab Abedalrahman ◽  
Ashoor Sarhat ◽  
Jawad Al-Diwan
Keyword(s):  
Clinical Presentation ◽  
Age Distribution ◽  
Cross Sectional Study ◽  
Comorbid Disease ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Coronary Vascular Disease ◽  
Full Physical Examination ◽  
The Mean

The COVId19 pandemic is a newly emerging infectious disease that needs to be understood thoroughly in order to be controlled. This study aimed to study the clinical and laboratory characteristics of the COVID19 patient. Patient and methods: A cross-sectional study was done in Iraq, at Salahadeen general hospital from the period 1st March to the end of May 2020 on patients diagnosed with COVID 19. A total of 75 COVID19 patients enrolled in the study. a full history was taken, a full physical examination was done, computerized tomography, and laboratory tests. Results: The age distribution of the COVID19 patient were commonly aged (30-50 years) 37(49.3%), and those aged <30 years represented about 6(8%) of the sample. The dominant gender was male 43(57.3%). About 58 (77.3%) of the patient had comorbid disease, coronary vascular disease was 49(65.3%), hypertension was found among 47(62.7%), DM was found among 40(53.3%). Smoking found among 35(46.7%) of the patients. The commonest symptoms were dyspnea 63(84%), fever 51(68%), Myalgia 46(61.3%), loss of smell 8(10.7%), vomiting 8(10.7%), sputum 8(10.7%), loss of taste 6(8%), diarrhea 6(8%), dry mouth found among 6(8%), cough 6(8%), fatigue 5(6.7%)followed by arthralgia 4(5.3%), and chest pain 3(4%). The mean Spo2% was (88±6.6), heart rate was (103±23.3), the mean respiratory rate was (17.7±4.1), the mean temperature value was (38.1±1.1), and the mean C - reactive protein rate was (49.8±41.2). The CBC shows that Lymphopenia was reported among 34(45.3%) of the patient, leukocytosis reported among 19 (25.3%) of the patient. Chest CT revealed that mean lung involvement was (16.6±14.7%). Conclusion: The commonest presentation of the patient was dyspnea, followed by fever. Digestive symptoms and myalgia were common. COVID19 maybe became a stigma in our community and educational programs were needed to overcome this problem. Keywords: COVID19 infection, clinical presentation, CT, Iraq.

scholarly journals ASSESSMENT OF THE FREQUENCY OF DIFFERENT PATTERNS OF CLINICAL PRESENTATION OF CHILDREN PRESENTING WITH CONGENITAL ADRENAL HYPERPLASIA

2021 ◽  
Vol 31 (04) ◽  
pp. 178-181
Author(s):  
Habib Ullah ◽  
Fayiza Manzoor Ahmad ◽  
Sumaira Hmaid ◽  
Noor ul Ain Mehak ◽  
Assiya Afzal ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Clinical Presentation ◽  
Local Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Cross Sectional ◽  
Cousin Marriage ◽  
Salt Depletion ◽  
The Mean

Objective: To assess the frequency of different patterns of presentation of children presenting with congenital adrenal hyperplasia. Methodology:It was a cross sectional study conducted at the department of Pediatric, Fatima Memorial Hospital, Lahore, from19-12-2017 to 19-06-2018.92 infants who met the selectin criteria were recruited for the study. Then blood sample was obtained and if serum sodium <135mEq/L, then salt depletion was labeled. Then, infants underwent genital examination for assessment of genital virilization. All data is entered is specially designed Performa and analyzed in SPSS. Results: The mean age of patients was 6.52±3.56months. There were 49 (53.26%) male while 43 (46.74%) female infants. The mean weight of patients was 5.59±1.44kg. There were 21 (22.83%) cases of consanguineous marriage while 71 (77.17%) were other than cousin marriage. There were 63 (68.48%) had salt depletion while in 29 (31.52%) did not had salt depletion. There were 39 (42.39%) had genital virilization while in 53 (57.61%) did not had genital virilization. Conclusion: Thus the frequency of patterns (salt depletion and genital virilization) of Congenital adrenal hyperplasia are high in local population.

Epidemiological Study of Henoch-Schonlein Purpura and its Characteristics in Infected Children During 2009-2016

2021 ◽  
Vol 15 (6) ◽  
pp. 1629-1633
Author(s):  
Sadegh Dehghanmehr ◽  
Reza Naghdi ◽  
Farahnaz Irandegani ◽  
Hamed Taheri ◽  
Omar Pourbalouch ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Additional Treatment ◽  
Henoch Schonlein Purpura ◽  
Cross Sectional ◽  
Cutaneous Manifestations ◽  
The Mean ◽  
Autumn And Winter ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Introduction: Due to the different complications caused by Henoch-Schonlein purpura and in order to prevent additional treatment costs for patients, we decided to investigate the clinical features of cases of Henoch-Schonlein purpura. Materials and Methods: In this descriptive cross-sectional study, 52 children in whom the diagnosis of Henoch-Schonlein purpura was confirmed were enrolled in the study from 2009 to 2016. The instruments of this research include a researcher-made questionnaire with two parts. The first part is related to demographic characteristics including age, sex and season of referral and the second part was related to morbidity such as various symptoms. Data were collected from patients’ records and interviews with families and were analyzed using SPSS V.22. Results: Out of 52 patients, 30 (57.7%) were boys and 22 (43.3%) were girls. The mean age of patients was 3.02 to 6.58 years. Autumn and winter had the most clients of Henoch-Schonlein purpura. One of the most common manifestations seen in most patients was cutaneous manifestations. There was no significant relationship between gender and clinical manifestations and seasons of the year with these manifestations (p> 0.05). The results showed that age was significantly associated with renal manifestations (P <0.05). Conclusion: The results of this study showed that the prevalence of Henoch-Schonlein purpura disease is higher in boys. Cutaneous manifestations were seen in most patients and in patients with renal manifestations, the mean age was higher and significant. Keywords: Henoch-Schonlein purpura, clinical manifestations, complications, gender, age

scholarly journals Clinical Epidemiology and Paraclinical Findings in Tuberculosis Patients in North of Iran

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Farhang Babamahmoodi ◽  
Ahmad Alikhani ◽  
Jamshid Yazdani Charati ◽  
Amir Ghovvati ◽  
Fatemeh Ahangarkani ◽  
...  
Keyword(s):  
Clinical Epidemiology ◽  
Wide Spectrum ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Cross Sectional ◽  
Significant Difference ◽  
North Of Iran ◽  
History Of ◽  
The Mean ◽  
Mean Time

Background. Mycobacterium tuberculosis (M.TB) causes a wide spectrum of clinical diseases. The prevalence of TB is different in various parts of Iran and throughout the world. The present study aimed to determine the clinical epidemiology and paraclinical findings of TB. Methods. A cross-sectional study was conducted from 2008 to 2013. Patient demographic, clinical, and radiologic characteristics, picked up from the TB patient’s files, were collected using a standard questionnaire format. Data was entered and analyzed using the SPSS version 16 statistical software and P value < 0.05 was considered statistically significant. Results. Out of 212 patients enrolled in this study 62% were male and the mean age was about 50 years old. 98.6% were Iranian, and 46.2% were rural. Prevalence of smear-positive TB was 66.4%. Prevalence of positive PPD was 50.7% with no significant difference between HIV-positive and -negative patients (P = 0.8). Prevalence of diabetes mellitus was 17%. 36% of the patients had history of smoking and about 29.3% were addicted to narcotics. Cough was the most common symptom (94.5%) and 84% had sputum. 15 cases (7%) had extrapulmonary TB. The mean time between the onset of symptoms and admission was 46.5 days. The delay for admission between urban and rural populations was not significantly different (P = 0.68); but for those who were in prison, the delay was significant (P = 0.02). About 46% of the patients had cavitary lesions in CXRs. Conclusion. Timely diagnosis of TB especially in prisoners by understanding its most important epidemiologic characteristics and clinical features can help to make an early treatment and prevent spread of mycobacteria and their complications.

scholarly journals Frequency of cranio-autonomic symptoms in the patients of migraine presenting in an outpatient department of Dow University Hospital: A cross-sectional study

2021 ◽  
Vol 20 (1) ◽  
pp. 81-87
Author(s):  
Meraj Fatima ◽  
◽  
Muhammad Sohaib Asghar ◽  
Aijaz Ali ◽  
Dileep Kumar ◽  
...  
Keyword(s):  
Nasal Congestion ◽  
Daily Practice ◽  
Cross Sectional Study ◽  
Primary Objective ◽  
University Hospital ◽  
Common Symptom ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Autonomic Symptoms ◽  
The Mean

Objectives. Migraine is a prevalent debilitating neurological disorder manifested by frequent episodes of pounding headache. Cranial autonomic symptoms are frequently reported in patients of trigeminal autonomic cephalgias, but various studies also documented these cranio-autonomic symptoms in migraine patients as well. The primary objective of our study is to evaluate the prevalence of cranio-autonomic symptoms (CAS) amongst the patients suffering from migraines. Material and methods. This study was conducted as a descriptive, cross-sectional survey involving patients attending the neurology clinic at Dow University Hospital. 132 patients met the inclusion criteria (according to ICHDIII) and were assessed for the frequency of cranio-autonomic symptoms. Outcomes. The mean age recorded was 26.37 ± 6.31 years, while the mean duration of diagnosis was 23.54 ± 16.52 months. The frequency of cranio-autonomic symptoms was observed among 55% of the patients suffering from migraines in our study. The prominent symptom observed was lacrimation (56%), followed by nasal congestion (31%) and rhinorrhea (28%). The least prevalent symptom was ptosis (4%). Lacrimation was found more likely to be associated with the male gender (p = 0.096), while forehead/ facial sweating was found more prevalent in females (p = 0.162). The ciliary injection was frequent in conjunction with unilateral rather than a bilateral headache in the migraine patients (p= 0.055), while lacrimation was the most common symptom in the 21-30 years of age group followed by ciliary injection which was exclusively conspicuous in the same age category (p = 0.020). Conclusions. Cranio-autonomic symptoms were detected prevailing in our study population, and may present as a confounding factor in physician’s daily practice to diagnose migraine.

scholarly journals Clinical presentation of patients with significant left main stenosis.

2020 ◽  
Vol 27 (04) ◽  
pp. 772-778
Author(s):  
Rehan Riaz ◽  
M. Hamid Saeed ◽  
Kamran Sohail ◽  
Shahid Abbas ◽  
Ali Ehsan
Keyword(s):  
Clinical Presentation ◽  
Severe Disease ◽  
Interventional Cardiology ◽  
Cross Sectional Study ◽  
Common Finding ◽  
Common Symptom ◽  
Left Main ◽  
Cross Sectional ◽  
St Depression ◽  
St Segment

Objectives: Our objective was to evaluate the frequency of clinical presentation in patients with angiographically documented significant LMCA stenosis. Study Design: Cross sectional study. Setting: Department of Cardiac Catheterization and Interventional Cardiology, Punjab Institute of Cardiology Lahore. Period: Six Months from July to December 2018. Results: The mean age of presentation of disease was 59.78±5.76 year, 100 being males (58.82%) and 70 females (41.18%). Regarding frequency of distribution of symptoms, the most common symptom was chest pain. ST segment depression was most common finding (52.94%) on ECG. 50% of patients presented with stable angina,29.41% with unstable angina,8.82% with NSTEMI and 11.76% with STEMI.40% had pulmonary edema at initial presentation. Conclusion: LMCA stenosis is more common in males associated with severe disease in other coronary arteries. Isolated left main disease is rare and is more common in females as compared to males. Atherosclerosis was the major cause LMCA stenosis in the studied population. Severe forms of angina along with diffuse ST depression in multiple ECG leads are common findings in patients with LMCA stenosis.

scholarly journals Hemolytic disease of the new-born due to ABO incompatibility

2018 ◽  
Vol 5 (2) ◽  
pp. 605 ◽  
Author(s):  
Vijaya S. Kattimani ◽  
Ushakiran C. B.
Keyword(s):  
Blood Group ◽  
Total Duration ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Treatment Modalities ◽  
Cross Sectional ◽  
Indirect Bilirubin ◽  
Abo Incompatibility ◽  
Significant Difference ◽  
The Mean

Background: Better understanding of the clinical characteristics of HDN due to ABO incompatibility helps to optimise care. The objective of this study was to investigate the clinical manifestations and outcome of treatment modalities.Methods:This study was a hospital based cross sectional study conducted in the neonatal unit of Cheluvamba hospital attached to Mysore Medical College and Research Institute. A total of 50 neonates with blood group A or B born to mothers with blood group O; with jaundice and or anemia were enrolled during the period from January 2015 to December 2015. The various maternal and neonatal parameter and their association with development of jaundice and or anemia was studied. The outcome of treatment modalities was studied.Results: Out of 50 ABO Incompatible neonates 24 (48%) were male and 26 (52%) were female. The percentage of O–A and O–B incompatible neonates were 38% (19) and 72% (31), respectively. Jaundice was detected within the first 24 hours in 6% and 18% neonates had anemia. The mean age of presentation was 2.9±0.89 days. The various maternal and neonatal factors had no significant association with development of jaundice and or anemia due to ABO Incompatibility. The mean initial Indirect Bilirubin was 21.26±3.97, initial hemoglobin was 14.3±2.31 and the mean Reticulocyte count was 16.6±5.3. Total 22 (44%) neonates had laboratory evidence of hemolysis (microspherocytosis). DCT was positive in 4 (8%) neonates. The main clinical manifestation was jaundice and was treated with phototherapy in 49 (98%) of the cases. The mean duration of phototherapy was 53.84±9.82 hours. Only one infant required exchange transfusion and on follow up had no neurological sequelae. The mean total duration of stay was 3.6±1.2 days. There was no significant difference in the HDN due to either O–A or O–B incompatibility.Conclusions:Early identification of high risk neonates with ABO Incompatibility, diagnosis and early intervention can reduce morbidity and mortality. 

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