scholarly journals Factors Influencing Ascertainment Bias of Microsatellite Allele Sizes: Impact on Estimates of Mutation Rates

Genetics ◽  
2013 ◽  
Vol 195 (2) ◽  
pp. 563-572 ◽  
Author(s):  
Biao Li ◽  
Marek Kimmel
Keyword(s):  
Ascertainment Bias ◽  
Mutation Rates ◽  
Microsatellite Allele ◽  
Factors Influencing

scholarly journals Evidence for heterozygote instability in microsatellite loci in house wrens

2010 ◽  
Vol 7 (1) ◽  
pp. 127-130 ◽  
Author(s):  
Brian S. Masters ◽  
L. Scott Johnson ◽  
Bonnie G. P. Johnson ◽  
Jessica L. Brubaker ◽  
Scott K. Sakaluk ◽  
...  
Keyword(s):  
Mutation Rate ◽  
Microsatellite Loci ◽  
Allelic Variation ◽  
Empirical Support ◽  
Mutation Rates ◽  
Troglodytes Aedon ◽  
House Wren ◽  
House Wrens ◽  
Factors Influencing ◽  
Two Populations

Microsatellite loci have high mutation rates and high levels of allelic variation, but the factors influencing their mutation rate are not well understood. The proposal that heterozygosity may increase mutation rates has profound implications for understanding the evolution of microsatellite loci, but currently has limited empirical support. We examined 20 microsatellite mutations identified in an analysis of 12 260 meiotic events across three loci in two populations of a songbird, the house wren ( Troglodytes aedon ). We found that for an allele of a given length, mutation was significantly more likely when there was a relatively large difference in size between the allele and its homologue (i.e. a large ‘allele span’). Our results support the proposal of heterozygote instability at microsatellite loci.

Ascertainment bias and power of procedures to estimate differences between male and female mutation rates

1987 ◽  
Vol 75 (3) ◽  
pp. 296-296 ◽  
Author(s):  
Gerard J. te Meerman ◽  
Edgar R. Karel ◽  
Leo P. ten Kate
Keyword(s):  
Ascertainment Bias ◽  
Mutation Rates ◽  
Male And Female

Factors influencing adhesive bonding at the bone/implant interface

1992 ◽  
Vol 50 (2) ◽  
pp. 1114-1115
Author(s):  
Julie A. Martini ◽  
Robert H. Doremus
Keyword(s):  
Electron Microscopy ◽  
Adhesive Bonding ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Bone Implant ◽  
Factors Influencing ◽  
Lr White ◽  
Transmission Electron ◽  
New Zealand White Rabbits ◽  
Scanning Electron

Tracy and Doremus have demonstrated chemical bonding between bone and hydroxylapatite with transmission electron microscopy. Now researchers ponder how to improve upon this bond in turn improving the life expectancy and biocompatibility of implantable orthopedic devices.This report focuses on a study of the- chemical influences on the interfacial integrity and strength. Pure hydroxylapatite (HAP), magnesium doped HAP, strontium doped HAP, bioglass and medical grade titanium cylinders were implanted into the tibial cortices of New Zealand white rabbits. After 12 weeks, the implants were retrieved for a scanning electron microscopy study coupled with energy dispersive spectroscopy.Following sacrifice and careful retrieval, the samples were dehydrated through a graduated series starting with 50% ethanol and continuing through 60, 70, 80, 90, 95, and 100% ethanol over a period of two days. The samples were embedded in LR White. Again a graduated series was used with solutions of 50, 75 and 100% LR White diluted in ethanol.

Factors Influencing Electrophysiologic Responsivity in Normal Adults

1965 ◽  
Vol 8 (4) ◽  
pp. 323-347
Author(s):  
Robert Goldstein ◽  
Benjamin RosenblÜt
Keyword(s):  
Conditioned Stimulus ◽  
White Light ◽  
Pure Tone ◽  
Alpha Rhythm ◽  
White Women ◽  
White Men ◽  
Inverse Relation ◽  
Factors Influencing ◽  
Electrodermal Responses ◽  
Normal Adults

Electrodermal and electroencephalic responsivity to sound and to light was studied in 96 normal-hearing adults in three separate sessions. The subjects were subdivided into equal groups of white men, white women, colored men, and colored women. A 1 000 cps pure tone was the conditioned stimulus in two sessions and white light was used in a third session. Heat was the unconditioned stimulus in all sessions. Previously, an inverse relation had been found in white men between the prominence of alpha rhythm in the EEG and the ease with which electrodermal responses could be elicited. This relation did not hold true for white women. The main purpose of the present study was to answer the following questions: (1) are the previous findings on white subjects applicable to colored subjects? (2) are subjects who are most (or least) responsive electrophysiologically on one day equally responsive (or unresponsive) on another day? and (3) are subjects who are most (or least) responsive to sound equally responsive (or unresponsive) to light? In general, each question was answered affirmatively. Other factors influencing responsivity were also studied.

Factors Influencing Pressure in the Portal Vein as Studied in the Intact Animal

1950 ◽  
Vol 16 (1) ◽  
pp. 194-210 ◽  
Author(s):  
Frederick W. Hoffbauer ◽  
Jesse L. Bollman ◽  
John L. Grindlay
Keyword(s):  
Portal Vein ◽  
Intact Animal ◽  
Factors Influencing
Sign in / Sign up

Export Citation Format

Share Document