scholarly journals Application of Divide and Conquer Extended Genetic Algorithm to tertiary protein structure of chymotrypsin inhibitor-2

2006 ◽  
Vol 3 (4) ◽  
pp. 263-271
Author(s):  
A. Alfaro ◽  
M. Doan ◽  
J. Finke ◽  
M. Galdes ◽  
M. Zohdy
Keyword(s):  
Genetic Algorithm ◽  
Protein Structure ◽  
Divide And Conquer ◽  
Chymotrypsin Inhibitor ◽  
Chymotrypsin Inhibitor 2 ◽  
Tertiary Protein Structure

scholarly journals Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2

2006 ◽  
Vol 3 (4) ◽  
pp. 263-271 ◽  
Author(s):  
A. Alfaro ◽  
M. Doan ◽  
J. Finke ◽  
M. Galdes ◽  
M. Zohdy
Keyword(s):  
Genetic Algorithm ◽  
Tertiary Structure ◽  
Energy Landscape ◽  
Divide And Conquer ◽  
Three Dimension ◽  
Chymotrypsin Inhibitor ◽  
Chymotrypsin Inhibitor 2 ◽  
Tertiary Protein Structure ◽  
Structure Of Proteins ◽  
Lateral Sclerosis

Determining the method by which a protein thermodynamically folds and unfolds in three-dimension is one of the most complex and least understood problems in modern biochemistry. Misfolded proteins have been recently linked to diseases including Amyotrophic Lateral Sclerosis and Alzheimer's disease. Because of the large number of parameters involved in defining the tertiary structure of proteins, based on free energy global minimisation, we have developed a new Divide and Conquer (DAC) Extended Genetic Algorithm. The approach was applied to explore and verify the energy landscape of protein chymotrypsin inhibitor-2.

Novel use of a genetic algorithm for protein structure prediction: Searching template and sequence alignment space

2003 ◽  
Vol 53 (S6) ◽  
pp. 424-429 ◽  
Author(s):  
Bruno Contreras-Moreira ◽  
Paul W. Fitzjohn ◽  
Marc Offman ◽  
Graham R. Smith ◽  
Paul A. Bates
Keyword(s):  
Genetic Algorithm ◽  
Protein Structure ◽  
Protein Structure Prediction ◽  
Sequence Alignment ◽  
Structure Prediction

scholarly journals Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin

2015 ◽  
Vol 127 (24) ◽  
pp. 7220-7225 ◽  
Author(s):  
Blake Farrow ◽  
Michelle Wong ◽  
Jacquie Malette ◽  
Bert Lai ◽  
Kaycie M. Deyle ◽  
...  
Keyword(s):  
Protein Structure ◽  
Botulinum Neurotoxin ◽  
Tertiary Protein Structure
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