Detection of NOTCH1 Mutations in Adult T-Cell Leukemia/Lymphoma and Peripheral T-Cell Lymphoma

2007 ◽  
Vol 85 (3) ◽  
pp. 212-218 ◽  
Author(s):  
Daisuke Shimizu ◽  
Tomohiko Taki ◽  
Atae Utsunomiya ◽  
Hitoshi Nakagawa ◽  
Kenichi Nomura ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Adult T Cell Leukemia ◽  
Notch1 Mutations

scholarly journals Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

Blood ◽  
2010 ◽  
Vol 115 (5) ◽  
pp. 1026-1036 ◽  
Author(s):  
Javeed Iqbal ◽  
Dennis D. Weisenburger ◽  
Timothy C. Greiner ◽  
Julie M. Vose ◽  
Timothy McKeithan ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
High Expression ◽  
Molecular Signature ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Adult T Cell Leukemia

Abstract Peripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK+) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-unclassifiable was molecularly heterogeneous, but we were able to identify a molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL–not otherwise specified cases. Many of the pathologic features and substantial components of the molecular signature of AITL are contributed by the follicular dendritic cells, B-cell, and other stromal components. The expression of Th17-associated molecules in ALK+ ALCL was noted and may represent aberrant activation of Th17-cell differentiation by abnormal cytokine secretion. Adult T-cell leukemia/lymphoma has a homogeneous molecular signature demonstrating high expression of human T-lymphotropic virus type 1–induced genes. These classifiers reflect the biology of the tumor cells as well as their microenvironment. We also constructed a molecular prognosticator for AITL that appears to be largely related to the microenvironmental signature, and the high expression of 2 immunosuppressive signatures are associated with poor outcome. Oncogenic pathways and tumor-host interactions also were identified, and these findings may lead to better therapies and outcome in the future.

THP-COP regimen for the treatment of peripheral T-cell lymphoma and adult T-cell leukemia/lymphoma: a multicenter phase II study

2010 ◽  
Vol 84 (5) ◽  
pp. 391-397 ◽  
Author(s):  
Yasushi Takamatsu ◽  
Junji Suzumiya ◽  
Atae Utsunomiya ◽  
Koichi Maeda ◽  
Hitoshi Matsuoka ◽  
...  
Keyword(s):  
T Cell ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Adult T Cell Leukemia ◽  
Multicenter Phase

Cutaneous T-cell lymphoma with HTLV-I infection: clinical overlap with adult T-cell leukemia/lymphoma

2006 ◽  
Vol 45 (4) ◽  
pp. 447-449 ◽  
Author(s):  
F. H. Sakamoto ◽  
G. W. B Colleoni ◽  
S. P. Teixeira ◽  
M. Yamamoto ◽  
N. S. Michalany ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

Comparative study of cutaneous T-cell lymphoma and adult T-cell leukemia lymphoma

1991 ◽  
Vol 2 (3) ◽  
pp. 229
Author(s):  
Tetsuo Nagatani ◽  
Toshiko Matsuzaki ◽  
Naoko Baba ◽  
Hideaki Miyamoto ◽  
Hiroshi Nakajima
Keyword(s):  
T Cell ◽  
Comparative Study ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Palliative Radiation for Leukemic Arthropathy from Human T-Cell Lymphoma Virus-associated Adult T-Cell Leukemia Lymphoma

Rare Tumors ◽  
2015 ◽  
Vol 7 (3) ◽  
pp. 102-104 ◽  
Author(s):  
Brandon J. Birckhead ◽  
Jennifer L. Peterson ◽  
Ajay B. Patel ◽  
Robert C. Miller
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Palliative Radiation ◽  
Adult T Cell Leukemia ◽  
Human T Cell
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