scholarly journals Right Ventricle Involvement in Hypertrophic Cardiomyopathy and Role of Cardiac Magnetic Resonance in Hypertrophic Cardiomyopathy: Review Article

2021 ◽  
Vol 24 (4) ◽  
pp. E746-E750
Author(s):  
Weihao Ding ◽  
Sandeep Bhushan ◽  
Chen Ma ◽  
Yifan Yan ◽  
Zongwei Xiao
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Left Ventricle ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Complex Geometry ◽  
Imaging Modality ◽  
Phenotypic Expression ◽  
The Right ◽  
And Function

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease, and its main characteristic is symmetrical or asymmetrical hypertrophy of the left ventricle and/or right ventricle. Most previous studies mainly include the left ventricle for definition of HCM, thus neglecting the right ventricle. But recently, many studies have reported the right ventricular involvement in HCM. Histopathological results showed that similar pathogenic changes in both the right and left ventricles, which suggests common myopathic processes and sarcomere genetic mutations. Cardiovascular magnetic resonance (CMR) is a gold standard imaging modality to assess heart anatomy and function and provides highly accurate and reproducible measurements. CMR is very useful in characterizing the various phenotypes of right and left ventricles in HCM. CMR also can be useful in detecting early and dominant phenotypic expression of HCM. Due to the complex geometry of the right ventricle and its retrosternal position, echocardiography may not provide accurate measurements. CMR also provides more accurate and repeatable right ventricular measurements. Thus, right ventricle evaluation along with left ventricle should routinely be done for better assessment of HCM patients.

scholarly journals Role of Cardiac Magnetic Resonance in Detecting Biventricular Apical Hypertrophic Cardiomyopathy

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Nathan Zaher ◽  
Hammam Shereef ◽  
Rashid Al Hussain ◽  
John Dawdy ◽  
Diane Levine ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
General Population ◽  
Right Ventricular ◽  
Imaging Modality ◽  
Transthoracic Echocardiogram ◽  
Apical Hypertrophic Cardiomyopathy ◽  
Low Prevalence

Apical Hypertrophic Cardiomyopathy (ApHCM) is a rare variant of hypertrophic cardiomyopathy with a low prevalence in the general population. ApHCM with right ventricular involvement (BiApHCM) is largely unreported and may not be detected with conventional transthoracic echocardiogram (TTE) alone. Cardiac Magnetic Resonance (CMR) has been demonstrated to be a proficient imaging modality to diagnose BiApHCM. We present a case of BiApHCM that was diagnosed with TTE and further characterized by CMR. This imaging modality may be utilized more in the future to help diagnose and detect the prevalence of BiApHCM.

Failure of Cellularization of Ventriculotomy Patch Leading to Right Ventricular Pseudoaneurysm

2019 ◽  
Vol 11 (1) ◽  
pp. 123-126
Author(s):  
Sruti Rao ◽  
Robert D. Stewart ◽  
Gosta Pettersson ◽  
Carmela Tan ◽  
Suzanne Golz ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Ventricular Septal Defect ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Septal Defect ◽  
Tricuspid Atresia ◽  
Outflow Obstruction ◽  
Ventricular Outflow Obstruction ◽  
The Right ◽  
Double Inlet Left Ventricle

Enlargement of the bulboventricular foramen (BVF) in double-inlet left ventricle or the ventricular septal defect (VSD) in tricuspid atresia with transposition of the great arteries is one approach for prevention or treatment of systemic ventricular outflow obstruction. Most often, BVF/VSD restriction is bypassed preemptively or addressed directly at the time of Glenn/Fontan procedures as part of staged univentricular palliation. We describe a patient who underwent enlargement of a restrictive VSD during Fontan completion and subsequently presented with an asymptomatic pseudoaneurysm of the right ventricle at the ventriculotomy site.

scholarly journals Epigenetics, inflammation and metabolism in right heart failure associated with pulmonary hypertension

2017 ◽  
Vol 7 (3) ◽  
pp. 572-587 ◽  
Author(s):  
Nolwenn Samson ◽  
Roxane Paulin
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Pressure Overload ◽  
Right Heart Failure ◽  
Left Ventricular ◽  
Ventricular Failure ◽  
Pulmonary Arterial ◽  
Ventricle Hypertrophy ◽  
The Right

Right ventricular failure (RVF) is the most important prognostic factor for both morbidity and mortality in pulmonary arterial hypertension (PAH), but also occurs in numerous other common diseases and conditions, including left ventricle dysfunction. RVF remains understudied compared with left ventricular failure (LVF). However, right and left ventricles have many differences at the morphological level or the embryologic origin, and respond differently to pressure overload. Therefore, knowledge from the left ventricle cannot be extrapolated to the right ventricle. Few studies have focused on the right ventricle and have permitted to increase our knowledge on the right ventricular-specific mechanisms driving decompensation. Here we review basic principles such as mechanisms accounting for right ventricle hypertrophy, dysfunction, and transition toward failure, with a focus on epigenetics, inflammatory, and metabolic processes.

scholarly journals Dynamic pattern in the structural-functional parameters of the heart in children with myocardial pathology, taking into account morphological functional features of the right ventricle

2018 ◽  
pp. 32-36
Author(s):  
T. А. Holovko
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
Children And Adolescents ◽  
Systolic Dysfunction ◽  
Structure And Function ◽  
Dynamic Pattern ◽  
Functional Features ◽  
The Right ◽  
And Function ◽  
Myocardial Pathology

The purpose of the study was to study the dynamics of changes in morphofunctional heart changes inchildren with non-inflammatory pathology of myocardium on the background of ongoing therapy. There were examined 115 patients (11–18 years old) with various heart diseases.The systolic dysfunction of the myocardium was diagnosedin 50 of them, and treatment was prescribed. In the dynamics, a year later, 40 patients were examined.  It has been established that in children and adolescents, along withpathogenetic and cardiometabolic therapy, in parallel with the improvement of the structure and function of the right ventricle of the heart, morphofunctional indicators ofthe left ventricle are improved.

Adaptation to hypoxia alters energy metabolism in rat heart

1999 ◽  
Vol 276 (1) ◽  
pp. H71-H80 ◽  
Author(s):  
William L. Rumsey ◽  
Brian Abbott ◽  
Darci Bertelsen ◽  
Michael Mallamaci ◽  
Kevin Hagan ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Left Ventricle ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Systolic Pressure ◽  
Adaptation To Hypoxia ◽  
Glutamate Concentration ◽  
Right Ventricular Mass ◽  
The Right ◽  
Concentration Ratios

The present study characterized metabolic changes in the heart associated with long-term exposure to hypoxia, a potent stimulus for pulmonary hypertension and right ventricular hypertrophy. When anesthetized rats adapted to chronic hypoxia spontaneously respired room air, their mean right intraventricular peak systolic pressure (RVSP) was twice that in normal control animals with the same arterial [Formula: see text]. RVSP was linearly related to right ventricular mass ( r = 0.78). Oxidative capacity (O2consumption) of homogenates of right and left ventricles from both groups of rats was measured with one of the following substrates: pyruvate, glutamate, acetate, and palmitoyl-l-carnitine. Oxidation of all substrates was significantly greater in the left than in the right ventricle in normal rats but not in hypoxia-adapted animals, where it was the same, within the experimental error. O2 consumption by the left ventricle was greater in control than in experimental rats, but right ventricular O2 consumption was similar in the two groups. Maximal reaction velocity of cytochrome- c oxidase was about the same in the two ventricles, and there were no significant differences between control and hypoxia-adapted animals. HPLC analyses showed significantly higher aspartate levels and aspartate-to glutamate concentration ratios in both ventricles of hypoxic rats than in corresponding tissues from controls, indicative of a decreased flux through the malate-aspartate shuttle under conditions of O2 limitation. Myocardial glutamine levels were lower in hypoxic rats, and glutamine-to-glutamate concentration ratios decreased, although primarily in the pressure-overloaded right ventricle. These findings indicate that normal energy metabolism in the left ventricle differs from that in the right and that the differences, particularly those of amino acid metabolism, are markedly influenced by chronic exposure to hypoxia.

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