scholarly journals Serum Lp-PLA2 Level Predicting Coronary Artery Lesions in Children with Kawasaki Disease

2021 ◽  
Vol 24 (4) ◽  
pp. E611-E618
Author(s):  
Xiong Zhang ◽  
Ya-Wang Shao ◽  
Ya-Lan Zhang ◽  
Yi Liu
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Color Doppler ◽  
Intima Media Thickness ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Children ◽  
Coronary Artery Lesions ◽  
Cell Counts ◽  
Ifn Γ

Background: Kawasaki disease (KD) is an inflammatory disease associated with coronary vasculitis in children. In this study, we explored the correlation between Lipoprotein associated phospholipase A2 (Lp-PLA2) and coronary artery lesions (CAL) in children with KD. Methods: Ninety-three children with KD were divided into a normal coronary artery (NCA, 54 cases) group and coronary artery lesions (CAL, 39 cases) group, according to the results of echocardiography. Another 42 healthy children were selected as the control group. The serumal levels of Lp-PLA2, Interferon-γ(IFN-γ) and Interleukin-6 (IL-6) were determined by using an enzyme-linked immunosorbent assay. In addition, erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) level were analyzed. The left main coronary artery (LMCA), diameters of left anterior descending coronary artery (LADC), right proximal coronary artery (PRCA), and carotid intima-media thickness (IMT) were obtained by color Doppler ultrasound. The correlation between the above indexes and KD was analyzed. Results: The levels of white blood cell counts (WBC), ESR, CRP, IFN-γ, IL-6 and Lp-PLA2 as well as IMT were significantly increased in KD children (P < 0.05), and the levels of CRP, IFN-γ, IL-6 and Lp-PLA2 as well as IMT in the CAL group increased more significantly (P < 0.05). An increasing trend also has been described in the diameters of LMCA, LADC and PRCA for KD children with CAL compared with with NCA. The results of logistic regression analysis showed that the elevated levels of CRP, IFN-γ, IL-6 and Lp-PLA2 were independent risk factors for KD with CAL. Correlation analysis showed that Lp-PLA2 level was positively correlated with the levels of IFN-γ, IL-6 and CRP in CAL group and NCA group (respectively, all P < 0.01). In addition, a similar correlation was also described between Lp-PLA2 level and the diameters of LMCA, LADC and PRCA in CAL group (respectively, all P < 0.01). Conclusion: Lp-PLA2 may participate in the pathological mechanism of KD. Detection of the serum Lp-PLA2 level can be used in the diagnosis of KD disease and the assessment of coronary artery lesions in KD children.

scholarly journals Identifying Downregulation of Autophagy Markers in Kawasaki Disease

Children ◽  
2020 ◽  
Vol 7 (10) ◽  
pp. 166
Author(s):  
Fu-Chen Huang ◽  
Ying-Hsien Huang ◽  
Ho-Chang Kuo ◽  
Sung-Chou Li
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Early Stage ◽  
Heart Diseases ◽  
White Blood Cells ◽  
Ivig Therapy ◽  
Control Group ◽  
High Dose ◽  
Healthy Children ◽  
Coronary Artery Lesions

Kawasaki disease (KD) is the most common cause of heart disease acquired in childhood. Even if treated with high-dose intravenous immunoglobulin G (IVIG) at the early stage; children are still at risk of developing coronary artery lesions. Accumulating evidence suggests that autophagy is enhanced in various heart diseases. Evaluating the pathogenic role of autophagy in KD and coronary artery lesions (CAL) may aid in identifying a potential therapeutic target for the treatment or prevention of the disease. Blood samples were obtained from 20 children with KD at the onset of disease and 21 days after IVIG therapy. Twenty children with other causes of febrile disease and 20 healthy children were included as controls. Total RNA was extracted from white blood cells; and autophagy-related gene mRNA expression levels were measured using real-time polymerase chain reaction. The patients with KD had downregulated levels of LC3B mRNA (0.50 ± 0.06 vs. 1.67 ± 0.15; p < 0.001), BECN1 mRNA (0.70 ± 0.08 vs. 1.43 ± 0.23; p < 0.05), and ATG16L1 mRNA (0.28 ± 0.04 vs. 0.96 ± 0.16; p < 0.01) compared to the febrile control group. The values of these parameters all increased significantly 21 days after the IVIG therapy as follows: LC3B mRNA (1.77 ± 0.29 vs. 0.50 ± 0.06; p < 0.001), BECN1 mRNA (1.67 ± 0.36 vs. 0.70 ± 0.08; p < 0.05), and ATG16L1 mRNA (2.96 ± 0.43 vs. 0.28 ± 0.04; p < 0.001), while the level of ATG16L1 mRNA persists low in KD patients with CAL. Our results showed the autophagy-related genes expressions in KD and their change after IVIG administration. This suggests that autophagy may have a protective effect on KD.

scholarly journals Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Zhuoying Li ◽  
Dong Han ◽  
Jie Jiang ◽  
Jia Chen ◽  
Lang Tian ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Gene Polymorphisms ◽  
Cell Adhesion Molecule ◽  
Systemic Vasculitis ◽  
Healthy Children ◽  
Coronary Artery Lesions ◽  
Artery Disease ◽  
The Relationship

Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL).

scholarly journals The IL-1B Gene Polymorphisms rs16944 and rs1143627 Contribute to an Increased Risk of Coronary Artery Lesions in Southern Chinese Children with Kawasaki Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Lan Yan Fu ◽  
Xiantao Qiu ◽  
Qiu Lian Deng ◽  
Ping Huang ◽  
Lei Pi ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Healthy Children ◽  
Nucleotide Polymorphisms ◽  
Coronary Artery Lesions ◽  
Multicenter Studies ◽  
Southern Chinese ◽  
Increased Risk

Background. Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication is coronary artery injury. However, the etiology of KD remains unclear. The IL-1B polymorphisms rs16944 GG and rs1143627 AA and their diplotype GA/GA have been associated with significantly increased risk of intravenous immunoglobulin (IVIG) resistance in a Taiwanese population, but the relationship between rs16944 A/G and rs1143627 G/A and coronary artery lesions (CALs) in patients with KD has not been investigated. The present study is aimed at investigating whether the rs16944 A/G and rs1143627 G/A polymorphisms in IL-1B were associated with KD susceptibility and CALs in a southern Chinese population. Methods and Results. We recruited 719 patients with KD and 1401 healthy children. Multiplex PCR was used to assess the genotypes of single nucleotide polymorphisms (SNPs), including two SNPs of IL-1B, rs16944 A/G and rs1143627 G/A. According to the results, no significant association was observed between the IL-1B (rs16944 and rs1143627) polymorphisms and KD risk in the patients compared with the healthy controls in our southern Chinese population. However, in further stratified analysis, we found that children younger than 12 months with the rs16944 GG and rs1143627 AA genotypes of IL-1B had a higher risk of CALs than those with the AA/AG genotypes of rs16944 and GG/AG genotypes of rs1143627 (OR=2.28, 95% CI=1.32-3.95, P=0.0032, adjusted OR=2.33, 95% CI=1.34-4.04, P=0.0027). Conclusions. Our results indicated that there was no association between the rs16944 A/G and rs1143627 G/A gene polymorphisms and KD susceptibility. However, the rs16944 GG and rs1143627 AA genotypes of IL-1B may significantly impact the risk of CAL formation in children younger than 12 months, which may contribute to the pathogenesis of KD. These findings need further validation in multicenter studies with larger sample sizes.

scholarly journals Increased levels of serum Hcy and UA as well as the thickness of carotid intima-media correlates with the severity of coronary artery lesions

2019 ◽  
Author(s):  
Changming Tan ◽  
Jianming Li ◽  
Yangzhao Zhou ◽  
Feng Xu
Keyword(s):  
Coronary Artery ◽  
Elderly Patients ◽  
Pearson Correlation ◽  
Systolic Pressure ◽  
Intima Media Thickness ◽  
Serum Levels ◽  
Smoking History ◽  
Control Group ◽  
Coronary Artery Lesions ◽  
Experimental Group

Abstract Background To investigate the correlation between serum homocysteine (Hcy) and uric acid (UA) levels as well as carotid intima-media thickness (IMT) and the severity of coronary artery lesions in elderly patients with coronary heart disease (CHD).Methods A total of 156 elderly patients with CHD in the experimental group were further divided into low, middle and high score groups. Serum Hcy and UA levels, IMT, Gensini and Sullivan scores were measured and analyzed by Pearson correlation. The risk factors for CHD and the correlation were analyzed by single factor analysis and logistic regression.Results The serum levels of Hcy, UA and the IMT in the experimental group were significantly higher than those in the control group (all P < 0.001). Gensini scores showed that the levels of serum Hcy, UA, and the IMT in middle and high score groups were significantly higher than those in the low score group, while the high score group had the significant highest level (all P < 0.001). Serum Hcy, UA levels and the IMT were positively correlated with Gensini and Sullivan scores (all P < 0.001). And male gender, smoking, history of hypertension, systolic pressure, pulse pressure, Hcy, UA, IMT, and BMI were independently correlated with the severity of CHD (all P < 0.05).Conclusions The serum levels of Hcy and UA and the IMT in patients with CHD were significantly increased, and were positively correlated with the severity of coronary artery lesions, which may serve as diagnostic indicators.

Efficacy and Limitation of Infliximab Treatment for Children with Kawasaki Disease Intractable to Intravenous Immunoglobulin Therapy: Report of an Open-label Case Series

2012 ◽  
Vol 39 (4) ◽  
pp. 864-867 ◽  
Author(s):  
MASAAKI MORI ◽  
TOMOYUKI IMAGAWA ◽  
RYOKI HARA ◽  
MASAKO KIKUCHI ◽  
TAKUMA HARA ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Ivig Therapy ◽  
High Dose ◽  
Infliximab Treatment ◽  
Coronary Artery Lesions ◽  
Open Label ◽  
Intravenous Immunoglobulin Therapy ◽  
Cell Counts

Objective.Kawasaki disease (KD) is an acute febrile disease in infants and young children. Five percent to 8% of cases will be complicated with coronary dilatation or aneurysm, although introduction of high-dose intravenous immunoglobulin (IVIG) therapy has provided remarkable results for reducing the frequency of cardiac involvement. We describe the results of an open-label trial of infliximab, an anti-tumor necrosis factor-α monoclonal antibody, for suppressing the progression of coronary artery lesions in cases of KD refractory to extensive IVIG therapy. Plasma exchange (PE) was available as a rescue therapy for patients refractory to infliximab.Methods.Twenty eligible patients fulfilled the diagnostic criteria for KD, and were primarily treated with IVIG up to 4 g/kg. “Refractory to IVIG” was defined as persisting or reemerging fever > 38°C and positive fractional changes of C-reactive protein, white blood cell counts, or neutrophil counts 48 hours after IVIG infusion. These cases were treated with infliximab, 5 mg/kg, which should begin within 10 days of disease onset. PE for patients refractory to infliximab was performed with 5% albumin.Results.There was rapid improvement of inflammatory symptoms as well as normalization of the inflammatory markers. Sequential examination by echocardiography up to disease Day 30 revealed that the inflamed and mildly dilated coronary artery at the beginning of the study regressed to normal size in the convalescent phase. Two out of 20 patients showed incomplete improvement of inflammatory symptoms after infliximab treatment, and were provided with PE therapy, with no complications.Conclusion.Eighteen of 20 patients were effectively treated with infliximab, and 2 cases were effectively treated with PE to prevent progression to coronary artery lesions. No adverse event such as anaphylactoid reaction, heart failure, severe infectious diseases, or tuberculosis was observed in this trial.

scholarly journals Increased levels of serum Hcy and UA as well as the thickness of carotid intima-media correlates with the severity of coronary artery lesions

2019 ◽  
Author(s):  
Changming Tan ◽  
Jianming Li ◽  
Yangzhao Zhou ◽  
Feng Xu
Keyword(s):  
Coronary Artery ◽  
Elderly Patients ◽  
Pearson Correlation ◽  
Systolic Pressure ◽  
Intima Media Thickness ◽  
Smoking History ◽  
Control Group ◽  
Syntax Score ◽  
Study Group ◽  
Coronary Artery Lesions

Abstract Background: To investigate the correlation between serum homocysteine (Hcy) and uric acid (UA) levels as well as the carotid intima-media thickness (IMT) and the severity of coronary artery lesions in elderly patients with coronary heart disease (CHD). Methods: A total of 156 elderly patients (≥60 years old) with CHD in the study group ; 54 patients with normal coronary artery were selected as the control group. The study group were further divided into low (≤20 points, n=72), middle (21-39 points, n=56) and high (≥40 points, n=28) score groups according to SYNTAX score. Serum Hcy and UA levels, IMT, Gensini and Sullivan scores were measured and analyzed by Pearson correlation. The risk factors for CHD and the correlation were analyzed by single factor analysis and logistic regression. Results: SYNTAX scores showed that the levels of serum Hcy, UA, and the IMT in middle [(20.03 ± 7.88) μmol/L, (326.34 ± 79.34) μmol/L, (1.26 ± 0.07) mm)] and high score [(28.98 ± 8.04) μmol/L, (456.67 ± 98.34) μmol/L, (1.33 ± 0.08) mm] groups were significantly higher compared to the low score group [(11.34 ± 6.83) μmol/L, (206.78 ± 77.45) μmol/L, (1.19 ± 0.05) mm)], while the high score group had the highest levels (all P < 0.001). Serum Hcy, UA levels and the IMT were positively correlated with SYNTAX and Sullivan scores (all P < 0.001). Additionally, male gender, smoking, history of hypertension, systolic pressure, pulse pressure, Hcy, UA, IMT, and BMI independently correlated with the severity of CHD (all P < 0.05). Conclusions: The serum levels of Hcy and UA and the IMT in patients with CHD were significantly elevates, and positively correlated with the severity of coronary artery lesions, which may serve as diagnostic indicators.

scholarly journals Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Yapeng Lu ◽  
Rui Liu ◽  
Luting Zha ◽  
Shan Yuan ◽  
Lang Tian ◽  
...  
Keyword(s):  
Coronary Artery ◽  
High Risk ◽  
Kawasaki Disease ◽  
Protein C ◽  
Systemic Vasculitis ◽  
Vascular Diseases ◽  
Healthy Children ◽  
Coronary Artery Lesions ◽  
Ivig Resistance ◽  
Anticoagulant System

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance.

Magnetocardiographic recognition of abnormal depolarization and repolarization in patients with coronary artery lesions caused by Kawasaki disease

2019 ◽  
Vol 34 (10) ◽  
pp. 1571-1579
Author(s):  
Wataru Tamaki ◽  
Etsuko Tsuda ◽  
Syuji Hashimoto ◽  
Tamami Toyomasa ◽  
Mikiya Fujieda
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Lesions

scholarly journals Advanced glycation end product levels were correlated with inflammation and carotid atherosclerosis in type 2 diabetes patients

2020 ◽  
Vol 15 (1) ◽  
pp. 364-372 ◽  
Author(s):  
Jie Li ◽  
Haiyan Shangguan ◽  
Xiaoqian Chen ◽  
Xiao Ye ◽  
Bin Zhong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Color Doppler ◽  
Enzyme Linked Immunosorbent Assay ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Inflammatory Status ◽  
Tnf Α ◽  
Ifn Γ

AbstractDiabetes mellitus with atherosclerosis (AS) adds to the social burden. This study aimed to investigate whether advanced glycation end product (AGE) levels were correlated with inflammation and carotid AS (CAS) in type 2 diabetes mellitus (T2DM) patients. A total of 50 elderly T2DM patients and 50 age-matched senior healthy subjects were recruited in this study. T2DM patients were classified into two groups based on the intima–media thickness (IMT) of the carotid artery from color Doppler ultrasonography. Patients with IMT > 1 mm were classified into the T2DM + CAS group (n = 28), and patients with IMT < 1 mm were assigned as the T2DM + non-atherosclerosis (NAS) group (n = 22). The plasma levels of AGEs, receptor for AGE (RAGE), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) of all subjects were measured by enzyme-linked immunosorbent assay. The T-lymphocyte subsets were analyzed by a flow detector. T2DM + CAS patients showed significantly higher concentrations of AGEs, RAGE, TNF-α, and IFN-γ in the peripheral blood. The highest levels of CD4+ T cells were observed in the T2DM + CAS group. The AGE level was positively correlated with the concentrations of RAGE, TNF-α, IFN-γ, and CD4+. In summary, the results showed that the levels of AGEs may be correlated with the inflammatory status in T2DM patients with CAS.

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