scholarly journals Giant Aortic Syphilitic Aneurysm of The Ascending Aorta with Erosion in the Chest Wall: Case Report

2019 ◽  
Vol 22 (5) ◽  
pp. E401-E404
Author(s):  
Ovidiu Stiru ◽  
Roxana Carmen Geana ◽  
Liana Valeanu ◽  
Diana Sorostinean ◽  
Mihai Goicea ◽  
...  
Keyword(s):  
Case Report ◽  
Aortic Aneurysm ◽  
Unusual Case ◽  
Cardiovascular Complications ◽  
Ascending Aorta ◽  
Aortic Aneurysms ◽  
Ascending Aortic Aneurysm ◽  
Tertiary Syphilis ◽  
Surgical Aspects ◽  
Syphilitic Aortitis

Since the discovery of penicillin, the incidence of tertiary syphilis dramatically has decreased. However, cases of cardiovascular complications of syphilis still are present. Ascending aortic aneurysms are some of the most devastating complications. Nonetheless, syphilitic aortitis (SA) can appear and should be suspected in patients with syphilis and aortic aneurysm. We report a case of a 57-year-old patient with a large ascending aortic aneurysm with cartilage and rib erosion. The purpose of this article is to discuss the particular surgical aspects of this unusual case.

ASCENDING AORTIC ANEURYSM – A CASE REPORT

2020 ◽  
Vol 1 (3) ◽  
pp. 54-55
Author(s):  
Prathap Kumar. J.
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Case Report ◽  
Aortic Aneurysm ◽  
Ascending Aorta ◽  
Leg Pain ◽  
Ultrasound Screening ◽  
Ascending Aortic Aneurysm ◽  
Risk Of Mortality ◽  
Abdominal Aortic ◽  
Life Threatening

An aortic aneurysm is an abnormal dilation of the aorta to greater than 1.5 times its normal size. They usually cause no symptoms except when ruptured. Occasionally, there may be symptoms like abdominal, back, or leg pain. They are most commonly located in the abdominal aorta, but can also be located in the thoracic aorta, rarely in arch of aorta. Abdominal aortic aneurysm is more common in men, a disease that is often asymptomatic and has up to a 90% risk of mortality if the aneurysm ruptures. It can be easily diagnosed by an ultrasound screening, and if the aneurysm is > 5.5 cm, it can be surgically repaired to prevent a life-threatening rupture. Aneurysm of the ascending aorta is rare but can be easily diagnosed by echocardiogram.

scholarly journals The Role of Bicuspid Aortic Valve in Aortic Aneurysm Occurrence and Development

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Vitaliy Kravchenko ◽  
Ivan Kravchenko ◽  
Olha Pantas ◽  
Valentyna Zakharova
Keyword(s):  
Surgical Treatment ◽  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Aortic Arch ◽  
Histological Examination ◽  
Bicuspid Aortic Valve ◽  
Ascending Aorta ◽  
Aortic Aneurysms ◽  
Ascending Aortic Aneurysm

The paper presents the data on the diagnosis of bicuspid aortic valve (BAV) disease in the patients operated for ascending aortic (AA) aneurysm. A brief historical review of the study of the BAV problem is presented; the data on the BAV incidence in the development of ascending aortic aneurysm and its dissection, the results of surgical treatment of BAV disease in patients with AA aneurysm are displayed. The objective of the research was to study the role of the bicuspid aortic valve in the occurrence (dissection) of ascending aortic aneurysms. Materials and methods The retrospective analysis of the patients operated at the institute during the period of 1.01.2013 to 1.01.2019 for ascending aortic aneurysm or aneurysms of both ascending aorta and aortic arch confirmed that aneurysm occurrence (dissection) was caused by the presence of bicuspid valve. During this time, 1120 patients were operated on for ascending aortic aneurysm or aneurysms of both ascending aorta and aortic arch. 340 (30.4%) patients with diagnosed and confirmed BAV disease were included in the analysis. BAV diagnosis was based on echocardiography with obligatory intraoperative confirmation and on the basis of histological examination. Histological examination of the fragments of the aortic wall and aortic valve taken during operations was performed in 68 (20.0%) patients. Results and discussion BAV is the most common of all cardiac failures with a prevalence of up to 2% in the population constituting up to 30-50% of cases among the patients with aortal disorders. Two-dimensional echocardiography gives better results and provides an opportunity to detect BAV in 95% of cases, which was confirmed by our studies. According to our research, cases with BAV included 30.4% of all possible aneurysm causes, and BAV as a cause of dissection was noted in 46 (13.5%) of all dissecting aneurysms. Regarding the results of the surgical treatment, 2 patients out of 340 operated at the hospital stage died constituting 0.6%. Conclusions Among all ascending aortic aneurysms or aneurysms of both ascending aorta and aortic arch, BAV was determined as their cause in 30.4% of cases. Dissection (rupture) of the aortic aneurysm occurred in 13.5% of patients with aneurysm and bicuspid valve and thus required an urgent surgery.  Patients with BAV require lifelong care.

scholarly journals Ascending Aortic Aneurysm Presenting as Hoarseness of Voice: Case Report

2016 ◽  
Vol 4 (2) ◽  
pp. 61-63
Author(s):  
Md Nazmul Hasan ◽  
Md Khorshed Ahmed ◽  
Md Mukhlesur Rahman ◽  
Abu Sadique Abdullah ◽  
Md Abu Siddique ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Aortic Aneurysm ◽  
Aortic Aneurysms ◽  
Ascending Aortic Aneurysm ◽  
X Ray ◽  
Thoracic Aortic Aneurysms ◽  
Chest X Ray

Symptomatic thoracic aortic aneurysms (TAA) are rare. A 70 year-old man was admitted with hoarseness of voice for the last six months. Postero-anterior chest X-ray showed left hilar enlargement. Computerised thorax tomography (CTT) images were taken and a saccular TAA 8 cm in diameter was found. In this paper, we aimed to show that TAA should be considered as a differential diagnosis of patients with hoarseness of voice and hilar enlargement. Ibrahim Cardiac Med J 2014; 4(2): 61-63

Epigenetic Profiling Identifies Novel Genes for Ascending Aortic Aneurysm Formation with Bicuspid Aortic Valves

2015 ◽  
Vol 18 (4) ◽  
pp. 134 ◽  
Author(s):  
Asad A Shah
Keyword(s):  
Gene Expression ◽  
Aortic Aneurysm ◽  
Methylation Status ◽  
Aortic Aneurysms ◽  
Aortic Valves ◽  
Ascending Aortic Aneurysm ◽  
Novel Genes ◽  
Aneurysm Formation ◽  
Aortic Replacement ◽  
Bicuspid Aortic Valves

<p><strong>Background:  </strong>Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized.  We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patients.</p><p><strong>Methods:  </strong>Ascending aortic aneurysm tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves.  Genome-wide DNA methylation status was determined on DNA from tissue using the Illumina 450K methylation chip, and gene expression was profiled on the same samples using Illumina Whole-Genome DASL arrays.  Gene methylation and expression were compared between bicuspid and trileaflet individuals using an unadjusted Wilcoxon rank sum test.  </p><p><strong>Results:  </strong>Twenty-seven probes in 9 genes showed significant differential methylation and expression (P&lt;5.5x10<sup>-4</sup>).  The top gene was protein tyrosine phosphatase, non-receptor type 22 (<em>PTPN22</em>), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10<sup>-5</sup>) in bicuspid patients, as compared to tricuspid patients.  Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including <em>ACTA2</em> (4 probes, delta beta range:  -10.0 to -22.9%), which when mutated causes the syndrome of familial thoracic aortic aneurysms and dissections</p><p><strong>Conclusions:  </strong>Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending aortic aneurysms in patients with bicuspid aortic valves, modulated through epigenetic mechanisms.  The top gene was <em>PTPN22</em>, which is involved in T-cell receptor signaling and associated with various immune disorders.  These differences highlight novel potential mechanisms of aneurysm development in the bicuspid population.</p>

scholarly journals Syphilitic heart - a case report

2013 ◽  
Vol 02 (02) ◽  
pp. 089-092
Author(s):  
K C Jyothi ◽  
Shetty Shailaja ◽  
K C Mahadeva ◽  
M Kapil Dev
Keyword(s):  
Ventricular Hypertrophy ◽  
Left Subclavian Artery ◽  
Left Ventricular ◽  
Ascending Aorta ◽  
Mortality And Morbidity ◽  
Tertiary Syphilis ◽  
Appropriate Treatment ◽  
Male Cadaver ◽  
Great Vessels ◽  
Syphilitic Aortitis

AbstractHeart and its great vessels are involved in tertiary syphilis in the form of syphilitic aortitis often 20 years or more after primary infection is contracted. In a 60 year old male cadaver, we found an enlarged heart with aneurysm of ascending aorta and semilunar septa was found protruding in to the lumen of arch of aorta distal to the origin of left subclavian artery. Right pulmonary vessels were dilated. Right and left atrial cavity were dilated, left ventricular hypertrophy with dilatation was noted. Hispathological findings of the specimens were suggestive of syphilitic aortitis. Cardiovascular syphilis though uncommon is still a significant cause of mortality and morbidity, which can be reduced by adequate screening, accurate diagnosis and appropriate treatment.

Results of a three-year follow-up after endovascular therapy with multilayer flow modulator in complex thoracoabdominal aortic aneurysm: A case report

Vascular ◽  
2020 ◽  
pp. 170853812093351
Author(s):  
Nazım Kankılıç ◽  
Mehmet S Aydın
Keyword(s):  
Case Report ◽  
Aortic Aneurysm ◽  
Renal Artery ◽  
Medical Center ◽  
Left Kidney ◽  
Thoracoabdominal Aortic Aneurysm ◽  
Aortic Aneurysms ◽  
Left Renal Artery

Objectives Studies on the short-, medium and long-term effects of flow guiding stents are still limited. In this case report, we present three-year follow-up of the multilayer flow modulator stent in a 55-year-old patient with Crawford Type 2 thoracoabdominal aortic aneurysm. Methods A 55-year-old male patient with Crawford Type 2 thoracoabdominal aortic aneurysm had applied to our medical center. The aneurysm involved coeliac truncus and superior mesenteric artery and extended to the renal artery ostia. Multilayer flow modulator stent was successfully placed, and follow-up CT (Computed tomography) angiographic examination images recorded intermittently (36 months). Results After three years, it was observed that the left renal artery was thrombosed and the left kidney went to atrophy. Other major vascular branches were observed to be open. During this time, the aneurysm was completely closed with thrombus, but the diameter of the aneurysm continued to increase. Conclusions Multilayer flow modulator stents are safe in complex aortic aneurysms. The device increases the thrombus load in the aortic aneurysm and maintains the flow of the main vascular branches. But re-interventions, dilatation of the aneurysm sac and visceral branch obstructions are still challenging for multilayer flow modulator stents.

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