scholarly journals Application of Autologous Blood Cell Salvage in Off-Pump Coronary Artery Bypass Graft Operation

2017 ◽  
Vol 20 (3) ◽  
pp. 107
Author(s):  
Hui Zhao ◽  
Huimin Ma ◽  
Li Meng ◽  
Ziniu Zhao ◽  
Xiaoqiang Quan ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Blood Transfusion ◽  
Blood Cell ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Autologous Blood ◽  
Allogeneic Blood ◽  
Cell Salvage ◽  
Off Pump ◽  
Pump Coronary Artery Bypass

Objective: To analyze whether application of autologous blood cell salvage can reduce the transfusion volume of allogeneic blood and complications of blood transfusion in off-pump coronary artery bypass operations. Methods: We randomly divided 120 patients into autologous blood cell salvage group (experimental group, n = 60) and non-autologous blood cell salvage group (control group, n = 60). Volume of perioperative allogeneic blood transfusion of each patient was recorded. Moreover, complications and ICU retention times (H) of each patient were also recorded. The data were analyzed using t tests. Results: The volume of allogeneic blood transfusion was significantly less in the experimental group than in the control group. Conclusion: Application of autologous blood cell salvage in off-pump coronary artery bypass graft operation can reduce the volume of allogeneic blood transfusion, alleviate blood shortage, and reduce the incidence of postoperative complications, leading to medical, economic, and social benefits.

Advantages of Autologous Blood Transfusion in Off-Pump Coronary Artery Bypass

2009 ◽  
Vol 12 (5) ◽  
pp. E261-E265 ◽  
Author(s):  
Yuksel Ela ◽  
Mustafa Emmiler ◽  
Cevdet Ugur Kocogullari ◽  
Yuksel Terzi ◽  
Remziye Gul Sivaci ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Blood Transfusion ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Autologous Blood ◽  
Autologous Blood Transfusion ◽  
Off Pump ◽  
Pump Coronary Artery Bypass

scholarly journals Association of Perioperative Whole Blood Transfusion with Troponin I Release after Off-Pump Coronary Artery Bypass Surgery

2018 ◽  
Vol 13 (2) ◽  
pp. 55-58
Author(s):  
Mahfuza Begum ◽  
Rampada Sarker ◽  
Md Kamrul Hasan ◽  
Tanveer Zaman ◽  
Hosne Jahan ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Blood Transfusion ◽  
Coronary Artery Bypass ◽  
Whole Blood ◽  
Troponin I ◽  
Artery Bypass ◽  
Red Blood Cell Transfusion ◽  
Off Pump ◽  
Recipient Group ◽  
Pump Coronary Artery Bypass

Background: Increased postoperative levels of Troponin I (TnI) after Off-pump Coronary Artery Bypass Grafting (OPCABG) surgery can often be observed in patients in the absence of significant perioperative hemodynamic instability or any evident intra-operative technical problems or signs of graft failure. A study undertaken by Biancari and his collegues (2012) found that Red Blood Cell transfusion was associated with increased TnI release after elective OPCABG1. Serum TnI level is an established indicator of myocardial injury. This prospective observational study was conducted in the Department of Cardiac Surgery, National Institute of Cardiovascular Diseases and Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from January 2015 to December 2016 to assess whether intraoperative and immediate postoperative Whole Blood Transfusion resulted in increased release of TnI after isolated OPCABG operation.Materials & Methods: A total of 40 patients (34 males and 6 females) undergoing OPCABG were consecutively enrolled in the study, 20 patients in the transfusion recipient group and 20 patients in the non-transfusion recipient group. The groups were compared for pre-operative baseline characteristics and co-morbidities, per-operative techniques and events, and postoperative or end-point variables including Postoperative TnI level measured 12 hours at the end of surgery and a number of other clinical outcomes.Results: Both transfusion recipient and non-transfusion recipient groups had statistically indifferent baseline characteristics, co-morbidity counts, operative techniques and operative events. No significant difference (p = 1.000) was noted in case-counts with increased Postoperative TnI level between the groups (85% in the transfusion recipient group versus 90% in the non-transfusion recipient group). All other clinical outcomes were also found to be similarly distributed with no statistical difference between the groups.Conclusion: In contrast to Red Blood Cell transfusion in several other studies, perioperative Whole Blood transfusion was not associated with increased postoperative Troponin I (TnI) release after isolated offpump coronary artery bypass grafting (OPCABG) operation.University Heart Journal Vol. 13, No. 2, July 2017; 55-58

scholarly journals Intravenous Tranexamic Acid Decreases Blood Transfusion in Off-Pump Coronary Artery Bypass Surgery: A Meta-analysis

2020 ◽  
Vol 23 (1) ◽  
pp. E039-E049
Author(s):  
Liang Sun ◽  
Haiyan An ◽  
Yi Feng
Keyword(s):  
Coronary Artery ◽  
Blood Transfusion ◽  
Tranexamic Acid ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Postoperative Death ◽  
Off Pump ◽  
Thrombotic Complications ◽  
Pump Cabg ◽  
Pump Coronary Artery Bypass

Background: Tranexamic acid (TXA) has been widely used during on-pump coronary artery bypass graft (CABG) surgery owing to its antifibrinolytic effect. However, the efficacy and safety of TXA in off-pump CABG surgery remains unconfirmed, especially intravenous (IV) administration. Objective: The aim of this study was to evaluate the effectiveness and safety of IV administration of TXA in off-pump CABG settings. Methods and Results: A comprehensive literature search was performed to identify randomized controlled trials (RCTs) that compared IV use of TXA with placebo in the reduction of postoperative 24-hour blood transfusion, as well as postoperative death and thrombotic events. The combined estimations were compiled with a fixed-effects model or, if heterogeneity existed, a random-effects model. Funnel plots and Egger’s test were used to assess potential publication bias. Subgroup analyses were used to explore possible sources of heterogeneity. In total, 12 RCTs met the inclusion criteria. IV administration of TXA significantly reduced the risk of packed red blood cell (PRBC) transfusion [risk ratio (RR) = 0.61, 95% confidence interval (CI) 0.503 to 0.756, P < .001, I2 = 0.0%) during the 24 hours after surgery. However, there was no statistical significance in platelet (RR = 0.613, 95% CI 0.112 to 3.348, P = .572, I2 = 0.0%) or total fresh frozen plasma (FFP) (RR = 0.511, 95% CI 0.246 to 1.063, P = .073, I2 = 0.0%) transfusion. Also, no significant difference was found in major adverse events (death or thrombotic complications) (RR = 0.917, 95% CI 0.532 to 1.581, P = .756, I2 = 0.0%) between the 2 groups. Interestingly, further subgroup analysis demonstrated that IV TXA decreased the risk of prothrombin time (PT)- and international normalized ratio (INR)-guided FFP transfusion (RR = 0.462, 95% CI 0.296 to 0.721, P = .001, I2 = 0.0%). Conclusion: IV TXA was effective in reducing allogeneic blood component transfusion (PRBCs and PT- or INR-guided FFP transfusion), without increasing the incidence of postoperative death or thrombotic complications in off-pump CAB surgery.

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