The effect of decidual stromal cells on immune cells in the first trimester of pregnancy

2016 ◽  
Author(s):  
Laura James-Allan ◽  
Judith Cartwright ◽  
Guy Whitley
Keyword(s):  
Immune Cells ◽  
Stromal Cells ◽  
First Trimester ◽  
First Trimester Of Pregnancy

scholarly journals Expression and Functional Characterization of NOD2 in Decidual Stromal Cells Isolated during the First Trimester of Pregnancy

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99612 ◽  
Author(s):  
Yuan-yuan Zhang ◽  
Hui Chen ◽  
Chan Sun ◽  
Hua-zhao Wang ◽  
Mei-lan Liu ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Functional Characterization ◽  
First Trimester ◽  
First Trimester Of Pregnancy

scholarly journals Expression of stathmin in human uterus and decidualizing endometrial stromal cells

Reproduction ◽  
2006 ◽  
Vol 132 (4) ◽  
pp. 625-636 ◽  
Author(s):  
Kazuhiro Tamura ◽  
Mikihiro Yoshie ◽  
Hirotaka Nishi ◽  
Yumi Osakabe ◽  
Keiichi Isaka ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Embryo Implantation ◽  
First Trimester ◽  
Human Uterus ◽  
Endometrial Stromal Cells ◽  
Igf Binding ◽  
First Trimester Of Pregnancy ◽  
Igf Binding Protein ◽  
Interfering Rna ◽  
Extravillous Trophoblasts

The cytosolic phosphoprotein stathmin is upregulated at the site of embryo implantation in the rodents. However, stathmin expression in the human uterus has not yet been investigated. The distribution of uterine and placental stathmin was analyzed by immunohistochemistry, while stathmin mRNA expression was detected in endometrial tissues by the reverse transcriptase-PCR. Cultured endometrial stromal cells were used to investigate whether stathmin plays a role in decidualization. Stathmin is expressed specifically in the glandular epithelium and the stromal cells of human endometrial tissue. It is also expressed by cytotrophoblasts and extravillous trophoblasts, but not by syncytiotrophoblasts or decidual tissues during the first trimester of pregnancy. When stromal cells isolated from normal endometrial tissues were cultured and stimulated to decidualize by progesterone (P4) plus estrogen or dibutyryl cyclic 3′,5′-AMP, their total and phosphorylated stathmin levels decreased. Knocking down stathmin expression in the cultured stromal cells using small interfering RNA, before the cells were exposed to the decidualizing agents, significantly suppressed decidualization, as indicated by the decreased expression of IGF-binding protein-1 and prolactin. Stathmin is differently expressed in human endometrial and placental cells and may participate in the decidualization of endometrial stromal cells.

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

Impact of TSH during the first trimester of pregnancy in obstetric and fetal complications: Usefulness of 2.5 mIU/l cut-off value

2018 ◽  
Author(s):  
Berta Soldevila ◽  
Marta Hernandez ◽  
Carolina Lopez ◽  
Laura Cacenarro ◽  
Maria Martinez-Barahona ◽  
...  
Keyword(s):  
First Trimester ◽  
Fetal Complications ◽  
First Trimester Of Pregnancy

Relationship between TSH values in the first trimester of pregnancy and obstetric and neonatal complications

2018 ◽  
Author(s):  
Beatriz Torres Moreno ◽  
Gabriela Castillo Carvajal ◽  
Lucrecia Vegara Fernandez ◽  
del Val Teresa Lopez ◽  
Victoria Alcazar Lazaro ◽  
...  
Keyword(s):  
First Trimester ◽  
Neonatal Complications ◽  
First Trimester Of Pregnancy
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