Androgen receptor signalling in testicular Leydig cells is essential for Leydig cell maturation and survival

2014 ◽  
Author(s):  
Laura O'Hara ◽  
Kerry McInnes ◽  
Ioannis Simitsidellis ◽  
Steph Morgan ◽  
Laura Milne ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Leydig Cell ◽  
Leydig Cells ◽  
Cell Maturation ◽  
Receptor Signalling

scholarly journals Importance of the Androgen Receptor Signalling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis

2019 ◽  
Author(s):  
Nadia Y. Edelsztein ◽  
Rodolfo A. Rey
Keyword(s):  
Androgen Receptor ◽  
Sertoli Cell ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Pubertal Development ◽  
Cell Maturation ◽  
Receptor Signalling ◽  
Tight Junction Formation ◽  
Germ Cell Differentiation ◽  
Junction Formation

Androgens are key for pubertal development of the mammalian testis, a phenomenon tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signalling affects Sertoli cell function and morphology by concomitantly inhibiting some processes and promoting others that contribute jointly to the completion of spermatogenesis. We focus on the molecular mechanisms that underlie AMH inhibition by androgens at puberty, as well as on the role androgens have on Sertoli cell tight junction formation and maintenance and, consequently, on its effect on proper germ cell differentiation and meiotic onset during spermatogenesis.

scholarly journals The Leydig Cell MEK/ERK Pathway Is Critical for Maintaining a Functional Population of Adult Leydig Cells and for Fertility

2011 ◽  
Vol 25 (7) ◽  
pp. 1211-1222 ◽  
Author(s):  
Soichi Yamashita ◽  
Ping Tai ◽  
Jean Charron ◽  
CheMyong Ko ◽  
Mario Ascoli
Keyword(s):  
Leydig Cell ◽  
Leydig Cells ◽  
Erk Pathway ◽  
Adult Leydig Cells

A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man

1995 ◽  
Vol 14 (7) ◽  
pp. 562-572 ◽  
Author(s):  
DE Prentice ◽  
AW Meikle
Keyword(s):  
Leydig Cell ◽  
Leydig Cells ◽  
Safety Assessment ◽  
Hormonal Status ◽  
Control Mechanisms ◽  
Hormone Production ◽  
Drug Induced ◽  
Cell Hyperplasia ◽  
Etiological Factors ◽  
Func Tion

This paper describes control of normal Leydig cell func tion and testosterone production. The macroscopic and histopathological appearances of spontaneous Leydig cell hyperplasias and tumors (LCT) in the rat are reviewed together with their incidence and hormonal status. Drugs which induce LCTs in chronic studies are discussed and include busereline, carbamazepine, cimetidine, finas teride, flutamide, gemfibrozil, histrelin, hydralazine, indomethacin, isradipine, lactitol, leuprolide, metronida zole, mesulergine, nafarelin, norprolac and vidarabine. The known mechanisms of LCT induction in the rat are reviewed together with other possible etiological factors. The incidence, clinical picture and etiological factors of LCTs in man are also surveyed. Hormone production in Leydig cells and LCTs in rats and man are compared. Differences between the two species are considered, par ticularly with regard to Leydig cell control mechanisms. The paper concludes that drug-induced LCTs in rats are most probably not predictive for man and their occurrence has little relevance in human safety assessment.

scholarly journals Conazole fungicides inhibit Leydig cell testosterone secretion and androgen receptor activation in vitro

2014 ◽  
Vol 1 ◽  
pp. 271-283 ◽  
Author(s):  
Maarke J.E. Roelofs ◽  
A. Roberto Temming ◽  
Aldert H. Piersma ◽  
Martin van den Berg ◽  
Majorie B.M. van Duursen
Keyword(s):  
Androgen Receptor ◽  
Leydig Cell ◽  
Receptor Activation ◽  
Testosterone Secretion ◽  
Androgen Receptor Activation

scholarly journals Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Mohammad Asim ◽  
Firas Tarish ◽  
Heather I. Zecchini ◽  
Kumar Sanjiv ◽  
Eleni Gelali ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Synthetic Lethality ◽  
Receptor Signalling

Androgen Receptor Signalling Promotes a Luminal Phenotype in Mammary Epithelial Cells

2018 ◽  
Vol 24 (1) ◽  
pp. 99-108 ◽  
Author(s):  
Gerard A. Tarulli ◽  
Geraldine Laven-Law ◽  
Mona Shehata ◽  
Kirsty A. Walters ◽  
Iza M. Denis ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Receptor Signalling
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