Early development of bovine embryos depends on the cooperative action between oxidative and endoplasmic reticulum stresses

2014 ◽  
Author(s):  
Seung-Bin Yoon ◽  
Hae-Jun Yang ◽  
Seong-Eun Mun ◽  
Pil-Soo Jeong ◽  
Seon-A Choi ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Early Development ◽  
Bovine Embryos ◽  
Cooperative Action

scholarly journals Endoplasmic Reticulum Stress Accelerates p53 Degradation by the Cooperative Actions of Hdm2 and Glycogen Synthase Kinase 3β

2005 ◽  
Vol 25 (21) ◽  
pp. 9392-9405 ◽  
Author(s):  
Olivier Pluquet ◽  
Li-Ke Qu ◽  
Dionissios Baltzis ◽  
Antonis E. Koromilas
Keyword(s):  
Endoplasmic Reticulum ◽  
Tumor Suppressor ◽  
Er Stress ◽  
Nuclear Export ◽  
Glycogen Synthase ◽  
Nucleocytoplasmic Transport ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Cooperative Action ◽  
In Cells

ABSTRACT Inactivation of the tumor suppressor p53 by degradation is a mechanism utilized by cells to adapt to endoplasmic reticulum (ER) stress. However, the mechanisms of p53 destabilization by ER stress are not known. We demonstrate here that the E3 ubiquitin-ligase Hdm2 is essential for the nucleocytoplasmic transport and proteasome-dependent degradation of p53 in ER-stressed cells. We also demonstrate that p53 phosphorylation at S315 and S376 is required for its nuclear export and degradation by Hdm2 without interfering with the ubiquitylation process. Furthermore, we show that p53 destabilization in unstressed cells utilizes the cooperative action of Hdm2 and glycogen synthase kinase 3β, a process that is enhanced in cells exposed to ER stress. In contrast to other stress pathways that stabilize p53, our findings further substantiate a negative role of ER stress in p53 activation with important implications for the function of the tumor suppressor in cells with a dysfunctional ER.

β-Catenin localization and timing of early development of bovine embryos obtained from oocytes matured in the presence of follicle stimulating hormone

2007 ◽  
Vol 100 (3-4) ◽  
pp. 264-279 ◽  
Author(s):  
Silvia Modina ◽  
Francesco Abbate ◽  
Germana P. Germanà ◽  
Antonio Lauria ◽  
Alberto M. Luciano
Keyword(s):  
Early Development ◽  
Follicle Stimulating Hormone ◽  
Bovine Embryos ◽  
Stimulating Hormone

scholarly journals Novel transcripts and alternatively spliced genes are associated with early development in bovine embryos

animal ◽  
2012 ◽  
Vol 6 (8) ◽  
pp. 1199-1205 ◽  
Author(s):  
B. Zhang ◽  
F. Peñagaricano ◽  
H. Chen ◽  
H. Khatib
Keyword(s):  
Early Development ◽  
Bovine Embryos ◽  
Alternatively Spliced ◽  
Novel Transcripts

Effects of Granulosa Cell Mitochondria Transfer on the Early Development of Bovine Embryos In Vitro

2007 ◽  
Vol 9 (2) ◽  
pp. 237-246 ◽  
Author(s):  
Song Hua ◽  
Yong Zhang ◽  
Xiang-Chen Li ◽  
Li-Bing Ma ◽  
Jun-Wei Cao ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Early Development ◽  
Bovine Embryos ◽  
Mitochondria Transfer

scholarly journals MicroRNA-34c Expression in Donor Cells Influences the Early Development of Somatic Cell Nuclear Transfer Bovine Embryos

2014 ◽  
Vol 16 (6) ◽  
pp. 418-427 ◽  
Author(s):  
Bo Wang ◽  
Yongsheng Wang ◽  
Man Zhang ◽  
Yue Du ◽  
Yijun Zhang ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Early Development ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Bovine Embryos ◽  
Donor Cells

Dynamics of the endoplasmic reticulum during early development ofDrosophila melanogaster

2003 ◽  
Vol 54 (3) ◽  
pp. 217-225 ◽  
Author(s):  
Yves Bobinnec ◽  
Christiane Marcaillou ◽  
Xavier Morin ◽  
Alain Debec
Keyword(s):  
Endoplasmic Reticulum ◽  
Early Development
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