scholarly journals Association of placental nutrient sensing pathways with birth weight

Reproduction ◽  
2020 ◽  
Vol 160 (3) ◽  
pp. 455-468
Author(s):  
Maria-Luisa Lazo-de-la-Vega-Monroy ◽  
Karen-Alejandra Mata-Tapia ◽  
Juan-Antonio Garcia-Santillan ◽  
Maria-Angelica Corona-Figueroa ◽  
Martha-Isabel Gonzalez-Dominguez ◽  
...  
Keyword(s):  
Birth Weight ◽  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Physiological Role ◽  
Newborn Health ◽  
Cross Sectional Study ◽  
Nutrient Sensing ◽  
Cross Sectional ◽  
Important Indicator ◽  
Blood Hormones

Birth weight (BW) is an important indicator for newborn health. Both high and low BW is associated with increased risks for adult metabolic diseases. AMPK (AMP-activated protein kinase), mTOR (mechanistic target of rapamycin), and insulin/IGF1 (insulin-like growth factor 1) pathways may function as placental sensors of maternal hormonal and nutritional status. However, the physiological role of these pathways in placenta has not been completely elucidated. To evaluate expression and activation of AMPK, mTOR, and insulin/IGF1 pathways and its association with placental weight (PW), BW, and maternal hormonal and metabolic status, we performed a cross-sectional study in placentas from non-obese mothers with SGA (n = 17), AGA (n = 19) and LGA (n = 10) newborns. We analyzed placental expression of total and phosphorylated key proteins from the AMPK, mTOR and insulin/IGF1 pathways. Maternal and cord blood hormones were determined by ELISA. AMPK and LKB1 activation correlated negatively with PW and BW, cord leptin, and pregestational BMI. Placental SIRT1 inversely correlated with BW, cord leptin, neonatal HOMA-IR, and maternal IGF1. PGC1α correlated negatively with PW and BW. Phosphorylated mTOR positively correlated with maternal glucose, PW and BW. IGF1R was lower in SGA. No changes in p-IGF1R, INSRb, total AKT or p-AKT were found, and pPDK1 was lower in SGA and LGA. These results suggest that placental AMPK, insulin/IGF1, and mTOR pathways may influence fetal growth, perhaps regulating placental physiology, even in metabolically healthy pregnancies. Our study highlights these nutrient sensing pathways as potential molecular mechanisms modulating placental adaptations and, thus, long-term metabolic health.

scholarly journals A cross sectional study on socio-demographic and maternal factors associated with low birth weight babies among institutional deliveries in a tertiary care hospital, Hyderabad, Telangana

2018 ◽  
Vol 5 (11) ◽  
pp. 4901
Author(s):  
M. Sheeba Apoorva ◽  
Vimala Thomas ◽  
B. Kiranmai
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Psychosocial Development ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Important Indicator ◽  
Inter Pregnancy Interval

Background: Birth weight is an important indicator of new born growth, survival and psychosocial development. Globally, more than 20 million are born with low birth weight (LBW) and the prevalence of low birth weight in India is 20%. The study was conducted to find the proportion of low birth weight and the factors influencing the weight of the baby.Methods: A cross sectional study was conducted at Gandhi hospital, Telangana from September to November, 2015 using a semi structured questionnaire among 204 postnatal mothers.Results: Out of 204 live births, 26% were found to be low birth weight. About 44.4% LBW babies are born to teenage mothers and 70% among the mothers with height less than 140 cms. Of the pre-term babies, nearly half of the babies (49.3%) were low birth weight. Around 30.3% of LBW was found with an inter-pregnancy interval of <2 years. About 41.2% of the mothers having complications had low birth weight babies.Conclusions: Nearly one fourth of the newborns were low birth weight. Gender of the child, socioeconomic status, education, gestational age, inter pregnancy interval, medical complications were found to affect the birth weight.

scholarly journals Prevalence of underweight among preschool children attending anganwadi in Kannur district, Kerala, India

2017 ◽  
Vol 4 (7) ◽  
pp. 2361
Author(s):  
Anitha S. S. ◽  
A. K. Jayasree ◽  
Devaki Antherjanam S.
Keyword(s):  
Birth Weight ◽  
Preschool Children ◽  
Nutritional Status ◽  
Sampling Technique ◽  
Educational Status ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Important Indicator ◽  
Growth Standards ◽  
Study Population

Background: Child malnutrition is an important indicator of the nutritional and health status of a country. Preschool children call for focused attention in India because India has the highest percentage of undernourished children in the world. The objective of this study was to estimate the prevalence of underweight among preschool children attending Anganwadi centers (AWC) in Kannur district, Kerala.Methods: Cross-sectional study done during July 2013- June 2014 among pre-school children (3-6 years) attending 44 AWC spread over eleven revenue blocks in the district. AWC were selected using multistage random sampling technique. Body weight of the children were measured and compared with WHO Growth standards. Mothers were interviewed using a pilot-tested semi-structured questionnaire. Data was entered in EpiData version 3.1 and analysis was done using the SPSS version 12.Results: The total number of 3-6 year old children included in the study was 456. The prevalence of underweight in the study population was found to be 17.3%. In this study, nutritional status of the child was found to have significant association (p<0.05) with the child’s birth weight and maternal educational status.Conclusions: Maternal educational status has a major role in prevention of underweight among preschool children. Child’s birth weight also influences their nutritional status. 

scholarly journals Multimorbidity patterns in old adults and their associated multi-layered factors: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiao Lu ◽  
Yuan Wang ◽  
Lihong Hou ◽  
Zhenxing Zuo ◽  
Na Zhang ◽  
...  
Keyword(s):  
Latent Class ◽  
Metabolic Diseases ◽  
Ecological Model ◽  
Explanatory Power ◽  
Cross Sectional Study ◽  
Shanxi Province ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Old Patients ◽  
Old Adults

Abstract Background Influenced by various factors such as socio-demographic characteristics, behavioral lifestyles and socio-cultural environment, the multimorbidity patterns in old adults remain complex. This study aims to identify their characteristics and associated multi-layered factors based on health ecological model. Methods In 2019, we surveyed a total of 7480 participants aged 60+ by using a multi-stage random cluster sampling method in Shanxi province, China. Latent class analysis was used to discriminate the multimorbidity patterns in old adults, and hierarchical regression was performed to determine the multi-layered factors associated with their various multimorbidity patterns. Results The prevalence of multimorbidity was 34.70% among the old patients with chronic disease. Over half (60.59%) of the patients with multimorbidity had two co-existing chronic diseases. “Degenerative/digestive diseases”, “metabolic diseases” and “cardiovascular diseases” were three specific multimorbidity patterns. Behavioral lifestyles-layered factors had the most explanatory power for the three patterns, whose proportions of explanatory power were 54.00, 43.90 and 48.15% individually. But the contributions of other multi-layered factors were different in different patterns; balanced diet, medication adherence, the size of family and friendship network, and different types of basic medical insurance might have the opposite effect on the three multimorbidity patterns (p < 0.05). Conclusions In management of old patients with multimorbidity, we should prioritize both the “lifestyle change”-centered systematic management strategy and group-customized intervention programs.

scholarly journals The Prevalence of Necrotizing Enterocolitis and Associated Factors Among Enteral Fed Preterm and Low Birth Weight Neonates Admitted in Selected Public Hospitals in Addis Ababa, Ethiopia: A Cross-sectional Study

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110196
Author(s):  
Sitotaw Molla Mekonnen ◽  
Daniel Mengistu Bekele ◽  
Fikrtemariam Abebe Fenta ◽  
Addisu Dabi Wake
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Gestational Age ◽  
Associated Factors ◽  
Addis Ababa ◽  
Cross Sectional Study ◽  
Public Hospitals ◽  
Sectional Study ◽  
Cross Sectional

Necrotizing enterocolitis (NEC) remains to be the most critical and frequent gastrointestinal disorder understood in neonatal intensive care units (NICU). The presented study was intended to assess the prevalence of NEC and associated factors among enteral Fed preterm and low birth weight neonates. Institution based retrospective cross-sectional study was conducted on 350 enteral Fed preterm and low birth weight neonates who were admitted at selected public hospitals of Addis Ababa from March 25/2020 to May 10/2020. The data were collected through neonates’ medical record chart review. A total of 350 participants were enrolled in to the study with the response rate of 99.43%. One hundred eighty-four (52.6%) of them were male. The majority 123 (35.1%) of them were (32 + 1 to 34) weeks gestational age. The prevalence of NEC was (25.4%) (n = 89, [95% CI; 21.1, 30.0]). Being ≤28 weeks gestational age (AOR = 3.94, 95% CI [2.67, 9.97]), being (28 + 1 to 32 weeks) gestational age (AOR = 3.65, 95% CI [2.21, 8.31]), birth weight of 1000 to 1499 g (AOR = 2.29, 95% CI [1.22, 4.33]), APGAR score ≤3 (AOR = 2.34, 95% CI [1.32, 4.16]), prolonged labor (AOR = 2.21, 95% CI [1.35, 6.38]), maternal chronic disease particularly hypertension (AOR = 3.2, 95% CI [1.70, 5.90]), chorioamnionitis (AOR = 4.8, 95% CI [3.9, 13]), failure to breath/resuscitated (AOR = 2.1, 95% CI [1.7, 4.4]), CPAP ventilation (AOR = 3.7, 95% CI [1.50, 12.70]), mixed milk (AOR = 3.58, 95% CI [2.16, 9.32]) were factors significantly associated with NEC. Finally, the prevalence of NEC in the study area was high. So that, initiating the programs that could minimize this problem is required to avoid the substantial morbidity and mortality associated with NEC.

scholarly journals Inadequate Gestational Weight Gain and Exposure to Second-Hand Smoke during Pregnancy Increase the Risk of Low Birth Weight: A Cross-Sectional Study among Full-Term Infants

2021 ◽  
Vol 18 (3) ◽  
pp. 1068
Author(s):  
Muliana Edi ◽  
Yit Chin ◽  
Fui Woon ◽  
Geeta Appannah ◽  
Poh Lim ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Pregnant Women ◽  
Medical Records ◽  
Cross Sectional Study ◽  
Second Hand Smoke ◽  
Sectional Study ◽  
Cross Sectional ◽  
Shs Exposure ◽  
At Home

Despite the advancement of the healthcare system, low birth weight (LBW) remains as one of the leading causes of under-five mortality. This cross-sectional study aimed to determine the prevalence of LBW and its associated factors among 483 third trimester pregnant women recruited from six selected public health clinics in the Federal Territory of Kuala Lumpur and the state of Selangor, Malaysia. Pregnant women were interviewed for information on socio-demographic characteristics, smoking behaviour, and second-hand smoke (SHS) exposure at home and in the workplace. Information on the obstetrical history and prenatal care visits history were retrieved from the maternal medical records, while infant’s birth outcomes were retrieved from infant medical records. The prevalence of LBW (<2.5 kg) in infants was 10.4%, with a mean birth weight of 3.0 [standard deviation (SD) 0.4] kg. Results from the multivariable logistic regression model showed that inadequate weight gained during pregnancy [odds ratio (OR) = 2.41, 95% confidence interval (CI) = 1.18–4.90] and exposure to SHS at home (OR = 1.92, 95% CI = 1.03–3.55) were significantly associated with LBW. In conclusion, pregnant women should monitor their rate of weight gain throughout pregnancy and avoid SHS exposure at home to reduce the risk of delivering LBW infants.

scholarly journals Poor maternal anthropometric characteristics and newborns' birth weight and length: a cross-sectional study in Benin

2018 ◽  
Vol 11 (1) ◽  
pp. 71-77
Author(s):  
Sètondji G R Padonou ◽  
Badirou Aguemon ◽  
Gilles M A Bognon ◽  
Nicole E Houessou ◽  
Georgia Damien ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Anthropometric Characteristics

scholarly journals A cross-sectional study of glucose regulation in young adults with very low birth weight: impact of male gender on hyperglycaemia

BMJ Open ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. e000327 ◽  
Author(s):  
Ryosuke Sato ◽  
Hiroshi Watanabe ◽  
Kenji Shirai ◽  
Shigeru Ohki ◽  
Rieko Genma ◽  
...  
Keyword(s):  
Young Adults ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Cross Sectional Study ◽  
Male Gender ◽  
Glucose Regulation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Weight Impact

scholarly journals Risk Factors Associated with Low Birth Weight among Deliveries at Bharatpur Hospital

2017 ◽  
Vol 15 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Kamal Prasad Kandel ◽  
Sindhu Kafle
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Hyperemesis Gravidarum ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Normal Birth ◽  
Born Infant ◽  
Low Body Mass Index ◽  
Health Situation

Background: Babies with a birth weight of less than 2500 grams, irrespective of the period of their gestation are termed as Low Birth Weight (LBW) babies. Despite consistent efforts to improve the quality of maternal and child health, more than twenty million low birth-weight (LBW) babies are born every year throughout the world. Though, the health situation of Nepal has improved substantially over the years, the low birth-weight (LBW) rate is still high. The objective of this study was to assess the proportion of low birth weight and identify the associated factors for low birth weight in a live born infant among the institutionally delivered newborns. Methods: A hospital based cross sectional study was conducted in Obstetrics and Gynaecology ward of Bharatpur hospital, Bharatpur, from 17th September to 4th October , 2012. Altogether 480 respondents were taken and respondents were mothers who had delivered newborns in Bharatpur hospital.Results: A total of 480 births occurred during the study period, of which 480 met the study criteria. Among which 9.4% were low birth weight and 90.6% were normal birth weight .Overall mean birth weight was found to be 2.96 kg. Out of total 9.4% newborns were weighing less than 2.50 kg and mean birth weight 2.96kg. Conclusions: This study suggests that there were several factors interplaying which lead to LBW babies; which are age of mother at delivery,weight gain by mother during pregnancy, short, low body mass index and hyperemesis gravidarum was the strongest predictor in this study.

scholarly journals Association of Maternal Hemoglobin and Birth Weight at Paropakar Maternity and Women’s Hospital, Kathmandu

2017 ◽  
Vol 11 (2) ◽  
pp. 20-23
Author(s):  
Safiur Rahman Ansari ◽  
Gehanath Baral
Keyword(s):  
Birth Weight ◽  
Negative Correlation ◽  
Strong Correlation ◽  
Neonatal Death ◽  
Maternal Age ◽  
Pearson Correlation ◽  
Mode Of Delivery ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Aims: To examine the association between maternal hemoglobin with birth weight.Methods: Cross sectional study of obstetrics database at Paropakar Maternity and Women’s Hospital. Hospital delivery of over 18 years of age women tested for Pearson correlation using SPSS-17.Results: Total of 2085 cases analyzed. There was mean hemoglobin value of 12.05 ± 1.30 (95% CI=11.992-12.103) g/dL and no any significant impact on mode of delivery (p=0.15) and neonatal death (p=0.736). There was a small but a significant correlation (p<0.01) of maternal age with hemoglobin (r = 0.106) and birth weight (r = 0.093); but a very small negative correlation between maternal hemoglobin and birth weight.Conclusions: Optimal maternal hemoglobin during labor rules out any strong correlation with birth weight.

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