scholarly journals Obesity, energy balance and spermatogenesis

Reproduction ◽  
2017 ◽  
Vol 153 (6) ◽  
pp. R173-R185 ◽  
Author(s):  
Pedro F Oliveira ◽  
Mário Sousa ◽  
Branca M Silva ◽  
Mariana P Monteiro ◽  
Marco G Alves
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Energy Balance ◽  
Molecular Mechanisms ◽  
Sperm Quality ◽  
Reproductive Potential ◽  
Massive Weight Loss ◽  
Overweight And Obesity ◽  
Lifestyle Modifications ◽  
The Impact

Obesity has grown to pandemic proportions. It affects an increasing number of children, adolescents and young adults exposed to the silent comorbidities of this disorder for a longer period. Infertility has arisen as one important comorbidity associated with the energy dysfunction promoted by obesity. Spermatogenesis is a highly regulated process that is determined by specific energetic requirements. The reproductive potential of males relies on hormonal-dependent and -independent stimuli that control sperm quality. There are conflicting data concerning the impact of male overweight and obesity on sperm quality, as well as on the possible paternal-induced epigenetic trait inheritance of obesity. In addition, it remains a matter of debate whether massive weight loss induced by lifestyle interventions, drugs or bariatric surgery may or may not benefit obese men seeking fatherhood. Herein, we propose to discuss how energy balance may modulate hormonal signalling and sperm quality in overweight and obese men. We also discuss some molecular mechanisms that mediate obesity-related dysfunction in male reproductive system and how paternal obesity may lead to trait inheritance. Finally, we will discuss how lifestyle modifications and sustained weight loss, particularly the loss achieved by bariatric surgery, may revert some of the deleterious effects of obesity in men and their offspring.

scholarly journals Potential Adverse Effects of Female and Male Obesity on Fertility: A Narrative Review

2020 ◽  
Vol 18 (3) ◽  
Author(s):  
Mina Amiri ◽  
Fahimeh Ramezani Tehrani
Keyword(s):  
Weight Loss ◽  
Adverse Effects ◽  
Sperm Quality ◽  
Educational Interventions ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Reproductive Age ◽  
Miscarriage Rate ◽  
First Line Therapy ◽  
The Impact

Context: Despite several studies documenting that obesity affects female and male fertility and leads to multiple adverse reproductive outcomes, the mechanisms involved are not elucidated. We aimed to summarize the potential adverse effects of female and male obesity, as well as the impact of weight loss on their fertility status. Evidence Acquisition: This review summarizes papers investigating the potential adverse effects of female and male obesity and the impact of weight-loss interventions on fertility among reproductive age populations. PubMed, Scopus, Web of Science, and Google Scholar databases were searched for retrieving studies published up to November 2019 on obesity/overweight among reproductive age populations. Results: The review of 68 studies revealed that female and male obesity/overweight increases the risk of sub-fecundity and infertility. The destructive effects of female obesity on reproduction are attributed to a variety of ovarian and extra-ovarian factors. In women with overweight or obesity, the time taken to conceive is longer, and they have a decreased fertility rate, increased requirement for gonadotropins, and higher miscarriage rate when compared to those with normal weight. Male obesity may lead to subfertility, mainly because of the disruption of the hypothalamus-pituitary-gonadal (HPG) axis, increased testicular temperature, impairment of the physical and molecular structure of sperm, decreased sperm quality, and erectile dysfunction due to peripheral vascular disease. Most studies recommend lifestyle interventions as first-line therapy in the general population of women and men with obesity and infertility. Conclusions: This study shows the negative effects of female and male overweight and obesity on fertility. Therefore, educational interventions on the adverse effects of obesity and the benefits of weight reduction, such as increasing pregnancy rate, should be considered for couples seeking fertility.

Overweight, obesity, and abdominal adiposity

2015 ◽  
Author(s):  
Gabriele Riccardi ◽  
Maria Masulli
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Population Level ◽  
Overweight And Obesity ◽  
Lifestyle Changes ◽  
Moderate Intensity ◽  
Lifestyle Modifications ◽  
Cvd Risk ◽  
Obese People ◽  
Term Survival

Obesity is a serious chronic disease of epidemic and global proportions. The incidence of cardiovascular diseases (CVD) is increased in obese people. Since overweight and obesity are associated with decreased lifespan, weight loss might be expected to improve long-term survival and to have beneficial effects on CVD risk. The therapeutic approaches for obesity are lifestyle changes, drugs, and bariatric surgery. Lifestyle modifications include modest weight loss and moderate-intensity physical activity. A low-fat (low saturated fat), low-sugar diet rich in fruit and vegetables, as well as legumes and whole grains, should be advised for its beneficial impact on weight and cardiovascular risk. Bariatric surgery represents an effective treatment in cases of severe obesity. Prevention of overweight and obesity at the population level will probably play a major role in combating the present obesity epidemic. Combining different intervention strategies is probably the best choice for maximizing the effects and minimizing the costs.

Fad Diets: Dietary Dilemmas, Predicaments, and Recommendations for its Use

2020 ◽  
Vol 16 (9) ◽  
pp. 1362-1380
Author(s):  
Jyoti Singh ◽  
Prasad Rasane ◽  
Vidisha Tomer ◽  
Sawinder Kaur ◽  
Yogesh Gat ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Health Care Expenditures ◽  
Overweight And Obesity ◽  
Lifestyle Changes ◽  
Health Issues ◽  
Lifestyle Modifications ◽  
Treatment Measures ◽  
Long Time ◽  
Extra Weight

The health issues, mainly overweight and obesity are the growing concerns nowadays due to the associated factors and lifestyle changes which significantly have increased the individual’s health care expenditures. Fad diets are promoted as the easiest and simplest way of shedding the extra weight despite the availability of several treatments available. The prevention and treatment measures, including modification in lifestyle, dietary pattern, and physical activity, are the foundation of weight loss. However, the standard treatment measures are not effective for certain populations as they require long time adherence, which leads to the search for other approaches like fad diet. We steered a comprehensive literature review to present the facts related to fad diets to their efficacy and sustainability. Although fad diets have yielded tremendous positive results in weight loss and cardiovascular risk prevention, the studies reported death in long-term interventions and the results and some of them show side effects too. Randomized controlled trials have significantly reported weight loss in comparison with the popular fad diets; however, persisting on the same diet has also reported kidney problems, ketosis, and other metabolic related problems. The conclusion of this critical review reported that gradual weight loss could be attained by the combination of lifestyle modifications, physical activity, and recommended dietary approaches.

scholarly journals Decrease of dipeptidyl peptidase 4 activity is associated with weight loss after bariatric surgery

2021 ◽  
Author(s):  
Carsten T. Herz ◽  
Johanna M. Brix ◽  
Bernhard Ludvik ◽  
Guntram Schernthaner ◽  
Gerit-Holger Schernthaner
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Hepatic Injury ◽  
Dipeptidyl Peptidase ◽  
Diabetic Patients ◽  
Metabolic Dysfunction ◽  
Dipeptidyl Peptidase 4 ◽  
Cholesterol Levels ◽  
Glucagon Like Peptide 1 ◽  
The Impact

Abstract Purpose Dipeptidyl peptidase 4 (DPP4) is expressed and secreted by adipocytes. DPP4 induces insulin resistance independently of its effect on glucagon-like peptide 1, thus it is conceivable that DPP4 directly contributes to metabolic dysfunction in patients with morbid obesity. The aim of this study was to investigate the impact of weight loss induced by bariatric surgery on DPP4 activity, and whether these changes are associated with improvements in markers of metabolic dysfunction and fatty liver disease. Materials and Methods We included 68 non-diabetic patients who underwent bariatric surgery. Serum DPP4 activity was measured using a fluorogenic substrate before and after surgery. Results Results: After a median follow-up period of 12 (IQR 11-17) months, median serum DPP4 activity decreased from 230 (IQR: 194-273) to 193 (164-252) pmol/min (p=0.012). The decrease in DPP4 activity was significantly correlated with decreases in BMI, improved cholesterol levels, reduced hepatic injury markers as well as improved post-prandial insulin sensitivity. After multivariable adjustment, ΔDPP4 activity remained significantly associated with Δcholesterol (beta=0.341, p=0.025), ΔLDL cholesterol (beta=0.350, p=0.019), Δgamma-glutamyltransferase (beta=0.323, p=0.040) and ΔMatsuda index (beta=-0.386, p=0.045). Conclusion We demonstrated that weight loss induced by bariatric surgery results in decreased circulating DPP4 activity beyond the initial phase of weight loss. The associations between decreased DPP4 activity and improved cholesterol levels as well as hepatic injury markers point towards pleiotropic effects of DPP4 beyond glucose metabolism which warrant further investigation.

scholarly journals Erratum to: Differential Changes in Exercise Performance After Massive Weight Loss Induced by Bariatric Surgery

2012 ◽  
Vol 23 (2) ◽  
pp. 277-277 ◽  
Author(s):  
Britta Wilms ◽  
Barbara Ernst ◽  
Martin Thurnheer ◽  
Burkhard Weisser ◽  
Bernd Schultes
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Exercise Performance ◽  
Massive Weight Loss

Accuracy of total energy expenditure predictive equations after a massive weight loss induced by bariatric surgery

2018 ◽  
Vol 26 ◽  
pp. 57-65 ◽  
Author(s):  
Michele Novaes Ravelli ◽  
Dale A. Schoeller ◽  
Alex Harley Crisp ◽  
Natalie M. Racine ◽  
Karina Pfrimer ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Energy Expenditure ◽  
Total Energy ◽  
Massive Weight Loss ◽  
Total Energy Expenditure ◽  
Predictive Equations

scholarly journals Quality of Life before and after Sleeve Gastrectomy in Lebanese Population

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Marwan Alkassis ◽  
Fady Gh Haddad ◽  
Joseph Gharios ◽  
Roger Noun ◽  
Ghassan Chakhtoura
Keyword(s):  
Quality Of Life ◽  
Bariatric Surgery ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Sexual Pleasure ◽  
Life Questionnaire ◽  
Before And After ◽  
The Mean ◽  
The Impact

Introduction. Obesity is increasing worldwide and in Lebanon with a negative impact on the quality of life. The primary objective of this study is to measure the quality of life in obese subjects before and after bariatric surgery, depending on age, sex, and degree of weight loss. A secondary objective is to determine the impact of bariatric surgery on comorbidities associated with obesity. Materials and methods. Patients undergoing laparoscopic sleeve gastrectomy for BMI ≥ 30 kg/m2 between August 2016 and April 2017 were included. Participants completed the Moorehead-Ardelt Quality of Life Questionnaire II (MA II) prior to operation and one year after. Statistical analysis was carried out using SPSS statistics version 20.0. Results. 75 patients participated in the study. The majority were women (75%), and the mean age was 36.3 years. The mean weight loss was 36.57 kg (16–76). Initially, the total MA II score was −0.33 ± 0.93. Postoperatively, it increased to 1.68 ± 0.62 (p≤0.001). All MA II parameters improved after surgery (p≤0.001), but this improvement was independent of age and sex. Improvement in self-esteem, physical activity, work performance, and sexual pleasure was influenced by the degree of weight loss (p≤0.001). All comorbidities associated with obesity regressed significantly after sleeve gastrectomy (p<0.05) with the exception of gastroesophageal reflux and varicose veins of the lower limbs. Conclusion. Sleeve gastrectomy improves quality of life and allows reduction of comorbidities.

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