scholarly journals Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus)

Reproduction ◽  
2007 ◽  
Vol 135 (1) ◽  
pp. 41-53 ◽  
Author(s):  
T. Ding ◽  
H. Song ◽  
X. Wang ◽  
A. Khatua ◽  
B. C Paria
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Mesocricetus Auratus ◽  
Inhibitory Factor ◽  
Receptor Signaling ◽  
Uterine Receptivity ◽  
Golden Hamsters

Embryo-endometrial expression of leukemia inhibitory factor in the golden hamster (Mesocricetus auratus): increased expression during proestrous and window of implantation stages

2008 ◽  
Vol 20 (3) ◽  
pp. 440 ◽  
Author(s):  
Rajnish P. Rao ◽  
Bernd Fischer ◽  
Polani B. Seshagiri
Keyword(s):  
Golden Hamster ◽  
Hormonal Regulation ◽  
Leukemia Inhibitory Factor ◽  
Mesocricetus Auratus ◽  
Inhibitory Factor ◽  
Preimplantation Embryos ◽  
Coding Region ◽  
Blastocyst Implantation ◽  
Uterine Glands ◽  
Blastocyst Hatching

Leukemia inhibitory factor (LIF) is a pleiotropic IL-6 family cytokine and its maternal uterine expression is critical for mouse blastocyst implantation. In the golden hamster (Mesocricetus auratus), although the blastocyst hatching phenomenon is quite interesting and LIF is shown to regulate hatching, information is not available on the embryonic and uterine expression of LIF and hormonal regulation of LIF expression during the peri-implantation period. The present investigation is aimed at studying embryonic and uterine expression of LIF during preimplantation hamster development. We observed embryonic expression of LIF mRNA and protein in the 8-cell, morula and blastocyst stages. In cycling females, uterine LIF mRNA expression was maximal during the oestrogen-dominant phase of the oestrous cycle, i.e. proestrous stage. Interestingly, during pregnancy, both LIF mRNA and protein were highly upregulated on Days 3.5 and 4 (‘window of implantation’), implying a role for this cytokine in blastocyst hatching and implantation. Cell type-specific localisation of LIF mRNA and protein was observed predominantly in luminal epithelium and uterine glands with faint staining being detected in the stroma. The hamster uterus encoded a ~4.2 kb LIF transcript whose coding region, when cloned and sequenced, showed a high degree of identity to the murine cDNA counterpart. These data demonstrate that: (1) hamster preimplantation embryos show LIF mRNA and protein expression; (2) uterine expression of LIF mRNA and protein was dependent on elevated levels of circulating oestrogen, and (3) there is a possible functional association of LIF with the peri-implantation development in the golden hamster.

scholarly journals An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle

2012 ◽  
Vol 139 (1) ◽  
pp. 13-34 ◽  
Author(s):  
Liam C. Hunt ◽  
Aradhana Upadhyay ◽  
Jalal A. Jazayeri ◽  
Elizabeth M. Tudor ◽  
Jason D. White
Keyword(s):  
Skeletal Muscle ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Receptor Signaling ◽  
Leukemia Inhibitory Factor Receptor ◽  
Anti Inflammatory

scholarly journals Progesterone and interferon tau regulate leukemia inhibitory factor receptor and IL6ST in the ovine uterus during early pregnancy

Reproduction ◽  
2009 ◽  
Vol 137 (3) ◽  
pp. 553-565 ◽  
Author(s):  
Gwonhwa Song ◽  
M Carey Satterfield ◽  
Jinyoung Kim ◽  
Fuller W Bazer ◽  
Thomas E Spencer
Keyword(s):  
Early Pregnancy ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Signal Transducer ◽  
Uterine Receptivity ◽  
Leukemia Inhibitory Factor Receptor ◽  
Interferon Tau ◽  
Specific Manner ◽  
Ovine Uterus ◽  
Phosphorylated Stat3

The actions of leukemia inhibitory factor (LIF) via LIF receptor (LIFR) and its co-receptor, IL6 signal transducer (IL6ST), are implicated in uterine receptivity to conceptus implantation in a number of species including sheep. The present study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on the expression of LIFR and IL6ST in the ovine uterus. LIFR mRNA and protein were localized to the endometrial luminal (LE) and superficial glandular epithelia (sGE), whereas IL6ST mRNA and protein were localized primarily in the middle to deep GE. Both LIFR and IL6ST mRNAs and protein were more abundant in pregnant than cyclic ewes and increased from days 10 to 20 of pregnancy. Treatment of ovariectomized ewes with P4 and/or infusion of ovine IFNT increased LIFR and IL6ST in endometrial LE/sGE and GE respectively. Co-expression of LIFR and IL6ST as well as phosphorylated STAT3 was observed only in the upper GE of the endometrium as well as in the conceptus trophectoderm on days 18 and 20. In mononuclear trophectoderm and GE cells, LIF elicited an increase in phosphorylated STAT3 and MAPK3/1 MAPK proteins. Collectively, these results suggest that LIFR and IL6ST are both stimulated by IFNT and regulated by P4 in a complex stage- and cell-specific manner, and support the hypothesis that LIF exerts effects on the endometrial GE as well as conceptus trophectoderm during early pregnancy in sheep. Thus, LIF and STAT3 may have biological roles in endometrial function and trophectoderm growth and differentiation.

scholarly journals Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling

Endocrinology ◽  
2004 ◽  
Vol 145 (8) ◽  
pp. 3850-3857 ◽  
Author(s):  
R. R. Gonzalez ◽  
B. R. Rueda ◽  
M. P. Ramos ◽  
R. D. Littell ◽  
S. Glasser ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Interleukin 1 ◽  
Human Endometrium ◽  
Inhibitory Factor ◽  
Receptor Signaling
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