scholarly journals Changes in adenylyl cyclase activity in human endometrium during the menstrual cycle and in human decidua during pregnancy

Reproduction ◽  
1993 ◽  
Vol 98 (1) ◽  
pp. 33-39 ◽  
Author(s):  
N. Tanaka ◽  
K. Miyazaki ◽  
H. Tashiro ◽  
H. Mizutani ◽  
H. Okamura
Keyword(s):  
Menstrual Cycle ◽  
Adenylyl Cyclase ◽  
Human Endometrium ◽  
Cyclase Activity ◽  
Adenylyl Cyclase Activity ◽  
Human Decidua

scholarly journals Adenylyl cyclase activity in human decidua and myometrium during pregnancy and labour

Reproduction ◽  
1995 ◽  
Vol 105 (1) ◽  
pp. 141-145 ◽  
Author(s):  
K. Miyazaki ◽  
N. Tanaka ◽  
S. Kawakami ◽  
H. Okamura
Keyword(s):  
Adenylyl Cyclase ◽  
Cyclase Activity ◽  
Adenylyl Cyclase Activity ◽  
Human Decidua

Stimulation of the adenylyl cyclase activity in human endometrial membranes by VIP and related peptides

1993 ◽  
Vol 13 (2) ◽  
pp. 69-77 ◽  
Author(s):  
A. M. Bajo ◽  
L. G. Guijarro ◽  
M. G. Juarranz ◽  
P. Valenzuela ◽  
P. Martinez ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Binding Capacity ◽  
Maximal Activity ◽  
Human Endometrium ◽  
Cyclase Activity ◽  
Adenylyl Cyclase Activity ◽  
Maximal Stimulation ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Stimulation Of

Vasoactive intestinal peptide (VIP) has been shown to stimulate adenylyl cyclase activity in human endometrial membranes. The effect was dependent on the time and temperature of incubation as well as on the concentration of endometrial membrane proteins in the medium. In the presence of 1 μM GTP, half-maximal stimulation of adenylyl cyclase activity was observed at 25.0 ± 7.0 nM VIP, whereas the maximal activity (at 1 μM VIP)corresponded to an increase of about 140% with respect to basal values (7.5 ± 0.6 pmol cyclic AMP/min/mg of protein). However, the maximal stimulation of adenylyl cyclase activity was obtained with helodermin (1 μM) that increased the activity by 170% over the basal. The relative potency of VIP-related peptides upon the adenylyl cyclase activity was: helodermin (ED50 = 1.8 ± 1.4 nM) > VIP(ED50 = 25.0 ± 7.0 nM) > PHI (ED50 = 725.0 ± 127.2 nM). Secretin had a faint effect upon the adenylyl cyclase activity and glucagon was completely inefficient at this level. The presence of αs and αi subunits of G proteins in human endometrium was detected by immunoblot. Preliminary results showed the presence of two classes of 125I-VIP receptors in human endometrial membranes with the following stoichoimetric parameters: high affinity receptor (Kd=2.0 nM, binding capacity 0.1 pmol VIP/mg protein) and low affinity receptor (Kd = 0.43 μM, binding capacity 13.1 pmol VIP/mg protein). The present results together with the known presence of VIP in human uterus and the actions of this neuropeptide in the adjacent myometrial tissue support the idea that VIP and related peptides may have a role in human endometrium.

Calcium Entry Attenuates Adenylyl Cyclase Activity

CHEST Journal ◽  
1995 ◽  
Vol 107 (5) ◽  
pp. 1420-1425 ◽  
Author(s):  
William B. Abernethy ◽  
John F. Butterworth ◽  
Richard C. Prielipp ◽  
Jian P. Leith ◽  
Gary P. Zaloga
Keyword(s):  
Adenylyl Cyclase ◽  
Calcium Entry ◽  
Cyclase Activity ◽  
Adenylyl Cyclase Activity

scholarly journals Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

Neuron ◽  
1999 ◽  
Vol 23 (4) ◽  
pp. 787-798 ◽  
Author(s):  
Scott T Wong ◽  
Jaime Athos ◽  
Xavier A Figueroa ◽  
Victor V Pineda ◽  
Michele L Schaefer ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Late Phase ◽  
Cyclase Activity ◽  
Long Term Memory ◽  
Adenylyl Cyclase Activity ◽  
Term Memory

A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin

2008 ◽  
Vol 381 (1) ◽  
pp. 86-93 ◽  
Author(s):  
Corinna M. Spangler ◽  
Christian Spangler ◽  
Martin Göttle ◽  
Yuequan Shen ◽  
Wei-Jen Tang ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Real Time ◽  
Cyclase Activity ◽  
Real Time Monitoring ◽  
Adenylyl Cyclase Activity ◽  
Fluorimetric Assay

scholarly journals κ-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments

FEBS Letters ◽  
1995 ◽  
Vol 361 (1) ◽  
pp. 70-74 ◽  
Author(s):  
Tomer Avidor-Reiss ◽  
Renata Zippel ◽  
Rivka Levy ◽  
Danielle Saya ◽  
Vittoria Ezra ◽  
...  
Keyword(s):  
Adenylyl Cyclase ◽  
Opioid Receptor ◽  
Cell Lines ◽  
Cyclase Activity ◽  
Adenylyl Cyclase Activity
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