scholarly journals Reduced burden of diabetes and improved quality of life: Experiences from unrestricted day-and-night hybrid closed-loop use in very young children with type 1 diabetes

Author(s):  
Musolino G ◽  
Dovc K ◽  
Boughton CK ◽  
Tauschmann M ◽  
Allen JM ◽  
...  
Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 121-LB
Author(s):  
AHMED H. ELDIB ◽  
ELENA TOSCHI ◽  
NOOR MAHMOUD ◽  
MHD WAEL TASABEHJI ◽  
SAHAR ASHRAFZADEH ◽  
...  

2017 ◽  
Vol 43 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Esti Iturralde ◽  
Molly L. Tanenbaum ◽  
Sarah J. Hanes ◽  
Sakinah C. Suttiratana ◽  
Jodie M. Ambrosino ◽  
...  

Purpose The first hybrid closed loop (HCL) system, which automates insulin delivery but requires user inputs, was approved for treatment of type 1 diabetes (T1D) by the US Food and Drug Administration in September 2016. The purpose of this study was to explore the benefits, expectations, and attitudes of individuals with T1D following a clinical trial of an HCL system. Methods Thirty-two individuals with T1D (17 adults, 15 adolescents) participated in focus groups after 4 to 5 days of system use. Content analysis generated themes regarding perceived benefits, hassles, and limitations. Results Some participants felt misled by terms such as “closed loop” and “artificial pancreas,” which seemed to imply a more “hands-off” experience. Perceived benefits were improved glycemic control, anticipated reduction of long-term complications, better quality of life, and reduced mental burden of diabetes. Hassles and limitations included unexpected tasks for the user, difficulties wearing the system, concerns about controlling highs, and being reminded of diabetes. Conclusion Users are willing to accept some hassles and limitations if they also perceive health and quality-of-life benefits beyond current self-management. It is important for clinicians to provide a balanced view of positives and negatives to help manage expectations.


2014 ◽  
Vol 24 (9-10) ◽  
pp. 1199-1209 ◽  
Author(s):  
Linda J. Herbert ◽  
Lauren Clary ◽  
Victoria Owen ◽  
Maureen Monaghan ◽  
Vanessa Alvarez ◽  
...  

2020 ◽  
Vol 22 (8) ◽  
pp. 639-642 ◽  
Author(s):  
Manuela Sinisterra ◽  
Samantha Hamburger ◽  
Carrie Tully ◽  
Emily Hamburger ◽  
Sarah Jaser ◽  
...  

2021 ◽  
pp. 193229682110354
Author(s):  
Aideen Daly ◽  
Sara Hartnell ◽  
Charlotte K. Boughton ◽  
Mark Evans

Background: Gastroparesis is associated with unpredictable gastric emptying and can lead to erratic glucose profiles and negative impacts on quality-of-life. Many people with gastroparesis are unable to meet glycemic targets and there is a need for new approaches for this population. Hybrid closed-loop systems improve glucose control and quality-of-life but evidence for their use in people with diabetic gastroparesis is limited. Methods: We present a narrative review of the challenges associated with type 1 diabetes management for people with gastroparesis and present a case series of 7 people with type 1 diabetes and gastroparesis. We compare glycemic control before and during the first 12 months of hybrid closed-loop therapy. Data were analyzed using electronic patient records and glucose management platforms. We also discuss future advancements for closed-loop systems that may benefit this population. Results: Five of 7 patients had data available for time in range before and during hybrid closed-loop therapy, and all had an improvement in percentage time in target glucose range, with the overall mean time in range increasing from 26.0% ± 15.7% to 58.4% ± 8.6% during HCL use, ( P = .004). There were significant reductions in HbA1c (83 ± 9 mmol/mol to 71 ± 14 mmol/mol) and mean glucose from 13.0 ± 1.7 mmol/L (234 ± 31 mg/dL) to 10.0 ± 0.7 mmol/L (180 ± 13 mg/dL) with use of a hybrid closed-loop system. Importantly, this was achieved without an increase in time in hypoglycemia ( P = .50). Conclusion: Hybrid closed-loop systems may represent a valuable approach to improve glycemic control for people with type 1 diabetes and gastroparesis. Prospective studies are required to confirm these findings.


2018 ◽  
Author(s):  
A Emile J Hendriks ◽  
Ross L Ewen ◽  
Yoke Sin Hoh ◽  
Nazia Bhatti ◽  
Rachel M Williams ◽  
...  

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