scholarly journals The NF-KB pathway and endocrine therapy resistance in breast cancer

2019 ◽  
Vol 26 (6) ◽  
pp. R369-R380 ◽  
Author(s):  
Phungern Khongthong ◽  
Antonia K Roseweir ◽  
Joanne Edwards
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Oestrogen Receptor ◽  
Nuclear Factor Kappa B ◽  
Treatment Resistance ◽  
Therapy Resistance ◽  
Nuclear Factor ◽  
Mechanisms Of Resistance ◽  
Endocrine Therapy Resistance

Breast cancer is a heterogeneous disease, which over time acquires various adaptive changes leading to more aggressive biological characteristics and development of treatment resistance. Several mechanisms of resistance have been established; however, due to the complexity of oestrogen receptor (ER) signalling and its crosstalk with other signalling networks, various areas still need to be investigated. This article focusses on the role of nuclear factor kappa B (NF-KB) as a key link between inflammation and cancer and addresses its emerging role as a key player in endocrine therapy resistance. Understanding the precise mechanism of NF-KB-driven endocrine therapy resistance provides a possible opportunity for therapeutic intervention.

Abstract P6-04-14: The role of PELP1-TFAP2C crosstalk in mediating endocrine-therapy-resistance in breast cancer

2020 ◽  
Author(s):  
Junhao Liu ◽  
Suryavathi Viswanadhapalli ◽  
Mengxing Li ◽  
Uday P Pratap ◽  
Yiliao Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Therapy Resistance ◽  
Endocrine Therapy Resistance

scholarly journals Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1424 ◽  
Author(s):  
Toshihiko Takeiwa ◽  
Kazuhiro Ikeda ◽  
Yuichi Mitobe ◽  
Kuniko Horie-Inoue ◽  
Satoshi Inoue
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Noncoding Rnas ◽  
Therapeutic Targets ◽  
Therapy Resistance ◽  
Long Noncoding Rnas ◽  
Endocrine Therapy Resistance ◽  
New Biomarkers

Long noncoding RNAs (lncRNAs) are defined as RNAs longer than 200 nucleotides that do not encode proteins. Recent studies have demonstrated that numerous lncRNAs are expressed in humans and play key roles in the development of various types of cancers. Intriguingly, some lncRNAs have been demonstrated to be involved in endocrine therapy resistance for breast cancer through their own mechanisms, suggesting that lncRNAs could be promising new biomarkers and therapeutic targets of breast cancer. Here, we summarize the functions and mechanisms of lncRNAs related to the endocrine therapy resistance of breast cancer.

scholarly journals ERα-targeted endocrine therapy, resistance and the role of GPER

Steroids ◽  
2019 ◽  
Vol 152 ◽  
pp. 108493 ◽  
Author(s):  
Richard A. Pepermans ◽  
Eric R. Prossnitz
Keyword(s):  
Endocrine Therapy ◽  
Therapy Resistance ◽  
Endocrine Therapy Resistance

scholarly journals Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer

2017 ◽  
Vol 7 (10) ◽  
pp. 1168-1183 ◽  
Author(s):  
Svasti Haricharan ◽  
Nindo Punturi ◽  
Purba Singh ◽  
Kimberly R. Holloway ◽  
Meenakshi Anurag ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Endocrine Therapy ◽  
Primary Breast Cancer ◽  
Cell Cycle Control ◽  
Therapy Resistance ◽  
Endocrine Therapy Resistance ◽  
Dependent Cell

scholarly journals Comprehensive Profiling of DNA Repair Defects in Breast Cancer Identifies a Novel Class of Endocrine Therapy Resistance Drivers

2018 ◽  
Vol 24 (19) ◽  
pp. 4887-4899 ◽  
Author(s):  
Meenakshi Anurag ◽  
Nindo Punturi ◽  
Jeremy Hoog ◽  
Matthew N. Bainbridge ◽  
Matthew J. Ellis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Endocrine Therapy ◽  
Therapy Resistance ◽  
Endocrine Therapy Resistance
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