scholarly journals Vitamin D mitigates the adverse effects of obesity on breast cancer in mice

2016 ◽  
Vol 23 (4) ◽  
pp. 251-264 ◽  
Author(s):  
Srilatha Swami ◽  
Aruna V Krishnan ◽  
Jasmaine Williams ◽  
Abhishek Aggarwal ◽  
Megan A Albertelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Adverse Effects ◽  
Postmenopausal Breast Cancer ◽  
Dietary Vitamin ◽  
Obese Mice ◽  
Established Risk Factor ◽  
Estrogen Synthesis ◽  
Dietary Vitamin D

AbstractObesity is an established risk factor for postmenopausal breast cancer (BCa), insulin resistance, and vitamin D deficiency, and all contribute to increased synthesis of mammary estrogens, the drivers of estrogen receptor-positive (ER+) BCa growth. As both dietary vitamin D and calcitriol treatments inhibit breast estrogen synthesis and signaling, we hypothesized that vitamin D would be especially beneficial in mitigating the adverse effects of obesity on ER+BCa. To assess whether obesity exerted adverse effects on BCa growth and whether vitamin D compounds could reduce these unfavorable effects, we employed a diet-induced obesity (DIO) model in ovariectomized C57BL/6 mice. Breast tumor cells originally from syngeneicMmtv-Wnt1transgenic mice were then implanted into the mammary fat pads of lean and obese mice. DIO accelerated the initiation and progression of the mammary tumors. Treatments with either calcitriol or dietary vitamin D reduced the adverse effects of obesity causing a delay in tumor appearance and inhibiting continued tumor growth. Beneficial actions of treatments with vitamin D or calcitriol on BCa and surrounding adipose tissue included repressedEsr1, aromatase, andCox2expression; decreased tumor-derived estrogen and PGE2; reduced expression of leptin receptors; and increased adiponectin receptors. We demonstrate that vitamin D treatments decreased insulin resistance, reduced leptin, and increased adiponectin signaling and also regulated the LKB1/AMPK pathway contributing to an overall decrease in local estrogen synthesis in the obese mice. We conclude that calcitriol and dietary vitamin D, acting by multiple interrelated pathways, mitigate obesity-enhanced BCa growth in a postmenopausal setting.

scholarly journals Effects of Vitamin D Supplementation on 1, 25-dihydroxyvitamin D Metabolism and Its Impact on Adipose Tissue Inflammation in Obese Mice (P24-004-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Chan Yoon Park ◽  
Shuang Zhu ◽  
Young Sun Jung ◽  
Sung Nim Han
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Vitamin D Supplementation ◽  
Dietary Vitamin ◽  
Epididymal Adipose Tissue ◽  
Mrna Levels ◽  
Obese Mice ◽  
Dihydroxyvitamin D ◽  
Vitamin D Levels ◽  
Dietary Vitamin D

Abstract Objectives Adipose tissue expresses CYP27B1 and VDR, suggesting local metabolism and function of 1,25-dihydroxyvitamin D (1,25(OH)2D) in adipose tissue. Obesity has been associated with dysregulation of 1,25(OH)2D levels. We investigated effects of vitamin D supplementation on 1,25(OH)2D metabolism and its impact in adipose tissue of obese mice. Methods Six-wk-old C57BL/6 mice were divided into 4 groups and fed experimental diets containing 10% or 45% kcal fat (CON or HFD) and differing in vitamin D content (1000 or 25,000 IU/kg of diet, DC or DS) for 13 wks. Serum 1,25(OH)2D and PTH levels were determined with radio- or enzyme-immunoassay. The mRNA levels of Cyp27b1, Cyp24a1, and Lrp2 in the kidney, and Cyp27b1, Vdr, and pro-inflammatory cytokines (Mcp-1, Rantes, Mip-1γ, Tnf-α, Il-6, Il-1β, and Ifn-γ) in the epididymal adipose tissue were determined by real-time PCR. Results Overall, serum 1,25(OH)2D levels were higher in DS groups compared with DC groups. When 1,25(OH)2D levels were compared between CON and HFD groups, differential pattern was observed depending on vitamin D levels in the diet. HFD-DC group showed higher serum 1,25(OH)2D and PTH levels compared with CON-DC group. However, in the DS groups, serum 1,25(OH)2D and PTH levels were not significantly affected by dietary fat amount. Renal Cyp24a1 mRNA levels, which could be up-regulated by dietary vitamin D, was higher in CON-DS group compared with CON-DC group. However, in the HFD groups, renal Cyp24a1 mRNA levels were similar in DC and DS groups. Mcp-1 and Rantes mRNA levels were higher in the HFD groups compared with CON groups, and their overall expression levels were down-regulated by vitamin D supplementation. Overall, mRNA levels of Il-6 and Il-1β were lower in the DS groups compared with DC groups. Conclusions Dietary vitamin D supplementation alleviated inflammatory responses in adipose tissue. Both 1,25(OH)2D in circulation and locally produced 1,25(OH)2D in adipose tissue might have contributed to the effect. Funding Sources Supported by the grant from the National Research Foundation (NRF) of Korea (NRF-2018R1D1A1B070491).

Joint Effects of Dietary Vitamin D and Sun Exposure on Breast Cancer Risk: Results from the French E3N Cohort

2010 ◽  
Vol 20 (1) ◽  
pp. 187-198 ◽  
Author(s):  
Pierre Engel ◽  
Guy Fagherazzi ◽  
Sylvie Mesrine ◽  
Marie-Christine Boutron-Ruault ◽  
Francoise Clavel-Chapelon
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sun Exposure ◽  
Dietary Vitamin ◽  
Joint Effects ◽  
Dietary Vitamin D

scholarly journals Vitamin D-effective solar UV radiation, dietary vitamin D and breast cancer risk

2011 ◽  
Vol 128 (6) ◽  
pp. 1425-1433 ◽  
Author(s):  
Kåre Edvardsen ◽  
Marit B. Veierød ◽  
Magritt Brustad ◽  
Tonje Braaten ◽  
Ola Engelsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Uv Radiation ◽  
Dietary Vitamin ◽  
Solar Uv Radiation ◽  
Solar Uv ◽  
Dietary Vitamin D

scholarly journals Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis

2021 ◽  
Vol 22 (22) ◽  
pp. 12361
Author(s):  
Armita Abolghasemi ◽  
Claudia Manca ◽  
Fabio A. Iannotti ◽  
Melissa Shen ◽  
Nadine Leblanc ◽  
...  
Keyword(s):  
Mental Health ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Side Effects ◽  
Gut Microbiota ◽  
Dietary Vitamin ◽  
Vitamin D Status ◽  
Atypical Antipsychotic Drug ◽  
Vitamin D Levels ◽  
Dietary Vitamin D

Vitamin D deficiency is associated with poor mental health and dysmetabolism. Several metabolic abnormalities are associated with psychotic diseases, which can be compounded by atypical antipsychotics that induce weight gain and insulin resistance. These side-effects may be affected by vitamin D levels. The gut microbiota and endocannabinoidome (eCBome) are significant regulators of both metabolism and mental health, but their role in the development of atypical antipsychotic drug metabolic side-effects and their interaction with vitamin D status is unknown. We studied the effects of different combinations of vitamin D levels and atypical antipsychotic drug (olanzapine) exposure on whole-body metabolism and the eCBome-gut microbiota axis in female C57BL/6J mice under a high fat/high sucrose (HFHS) diet in an attempt to identify a link between the latter and the different metabolic outputs induced by the treatments. Olanzapine exerted a protective effect against diet-induced obesity and insulin resistance, largely independent of dietary vitamin D status. These changes were concomitant with olanzapine-mediated decreases in Trpv1 expression and increases in the levels of its agonists, including various N-acylethanolamines and 2-monoacylglycerols, which are consistent with the observed improvement in adiposity and metabolic status. Furthermore, while global gut bacteria community architecture was not altered by olanzapine, we identified changes in the relative abundances of various commensal bacterial families. Taken together, changes of eCBome and gut microbiota families under our experimental conditions might contribute to olanzapine and vitamin D-mediated inhibition of weight gain in mice on a HFHS diet.

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