Coexistence of medullary carcinoma and papillary carcinoma of the thyroid in a 35 year old patient with RET protooncogene mutation

2019 ◽  
Author(s):  
Flavia Giselle Nuţu ◽  
Roxana Duşceac ◽  
Cătălina Poiană
Keyword(s):  
Papillary Carcinoma ◽  
Medullary Carcinoma ◽  
Ret Protooncogene

scholarly journals Expression of Human Pendrin in Diseased Thyroids

2003 ◽  
Vol 51 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Tetsuo Kondo ◽  
Nobuki Nakamura ◽  
Koichi Suzuki ◽  
Shin-ichi Murata ◽  
Akira Muramatsu ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Papillary Carcinoma ◽  
Apical Membrane ◽  
Medullary Carcinoma ◽  
Rt Pcr ◽  
Follicular Cells ◽  
Hormone Production ◽  
Functional Aspects ◽  
Mrna Analysis ◽  
Marked Proliferation

We examined pendrin expression in various diseased thyroid tissues by immunohistochemistry (IHC) using antiserum raised against human pendrin and by real-time quantitative RT-PCR. In normal thyroids the antiserum reacted with the apical membrane of follicular cells and its immunoreactivity was faint. In Graves’ thyroids, the IHC expression of pendrin appeared in a pattern similar to that of normal thyroids but it was more extensive and stronger, especially in areas showing marked proliferation of follicular cells. The immunoreactivities of pendrin in nodular goiters varied from case to case. In follicular adenomas, pendrin was localized in the follicle-forming parts of the tumor but was negative in trabecular parts. Pendrin was negative in all follicular carcinomas, papillary carcinomas, and in one case of medullary carcinoma. In quantitive mRNA analysis, the relative values of pendrin mRNA were significantly low in papillary carcinoma ( p<0.01), whereas the values in other diseased thyroids were not significantly different from those in normal thyroids. These results suggest that pendrin may play a role in thyroid hormone production as the apical porter of chloride/iodide and investigation of pendrin leads to a better understanding of functional aspects of the iodine transportation system in thyroid diseases.

scholarly journals Frequency & pattern of malignancy in solitary thyroid nodule

1970 ◽  
Vol 15 (1) ◽  
pp. 1-5
Author(s):  
Md Rafiqul Islam ◽  
AFM Ekramuddaula ◽  
MS Alam ◽  
MS Kabir ◽  
Md Delwar Hossain ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Histopathological Examination ◽  
Malignant Lesion ◽  
Medullary Carcinoma ◽  
College Hospital ◽  
Frequency Pattern ◽  
Cross Sectional ◽  
Female Ratio ◽  
Solitary Thyroid Nodule

This cross sectional study done in the department of Banghabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of July 2005 to October 2007 to determine frequency & pattern of malignancy in solitary thyroid nodule. For this study, 118 patients who were diagnosed as a case of malignancy in solitary thyroid nodule by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examination, were collected. In this study majority of the patients were within 21-40 years of age. Frequency of solitary thyroid nodule is more in female with male female ratio 1: 2.11 Majority of the nodules were firm (72.03%), others were hard (16.95%) and cystic (11.02%). Malignant lesion was more common in hard nodule (70%). Most of the nodules were cold (66.10%) among them 25.6% cases were malignant, followed by warm (30.5%) and hot (3.3%). No malignancy was found in hot nodule. FNAC showed colloid nodule (44%), cellular follicular lesion (29.66%), papillary carcinoma (12.7%), colloid degeneration (4.2%) and medullary carcinoma (1.6%) Out of 118 patients, histopathologically non malignant were 96 (81.35%) and malignant were 22(18.65%). Among malignant cases, 16 (72.72%) cases were papillary carcinoma, 4 (18.18%) cases were follicular carcinoma and 2(9.1%) cases were medullary carcinoma. Key words: Solitary thyroid nodule, FNAC, Papillary carcinoma, Follicular carcinomaDOI: 10.3329/bjo.v15i1.4303 Bangladesh J of Otorhinolaryngology 2009; 15(1): 1-5

scholarly journals Mixed Medullary – Papillary Carcinoma Thyroid: An Uncommon Variant of Thyroid Carcinoma

2014 ◽  
Vol 6 (02) ◽  
pp. 133-135 ◽  
Author(s):  
Manjula Jain ◽  
Deepti Verma ◽  
Shaji Thomas ◽  
Richa Chauhan
Keyword(s):  
Papillary Carcinoma ◽  
Medullary Carcinoma ◽  
Needle Aspiration ◽  
Lymph Node Excision ◽  
Thyroid Malignancy ◽  
Serum Calcitonin ◽  
Papillary Carcinoma Thyroid ◽  
Thyroid Swelling ◽  
Prognostic Implications ◽  
Thyroid Malignancies

ABSTRACTMixed medullary-papillary carcinoma of the thyroid, a variant of medullary carcinoma is a rare thyroid malignancy accounting for less than 1% of the thyroid malignancies. We are presenting a case of 57-year-old lady with complaints of gradually increasing thyroid swelling for 1½ months. Fine-needle aspiration was suggestive of medullary carcinoma. Serum calcitonin levels were elevated. The patient underwent total thyoidectomy with regional cervical lymph node excision. Histopathologically, the diagnosis of mixed medullary-papillary carcinoma of the thyroid was made. It is important to know about this entity due to its prognostic implications and to prevent any diagnostic dilemmas.

scholarly journals UTILITY OF FINE NEEDLE ASPIRATION CYTOLOGY (FNAC) AS A SCREENING TOOL IN DIAGNOSIS OF THYROID LESION IN CORRELATION WITH HISTOPATHOLOGY – A 4 YEARS STUDY

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. B.Naga Raja ◽  
Dr. G.Sobha Rani ◽  
Dr. V.Nagesh Kumar
Keyword(s):  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Medullary Carcinoma ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Nodular Goitre ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Common Malignancy

Background: Fine needle aspiration cytology (FNAC) has been proved to be a safe, cost effective, good screening and quick procedure for early diagnosis. Aim of study: To categorise various thyroid lesions To confirm preoperative suspected malignant cases Methods: This is a prospective study done over a period of four years from 2015 -2018. A total of 274 thyroid cases attending the outpatient department in Government General Hospital, Kadapa were sent for FNAC to the Department of Pathology, all these cases were categorised based on cyto- morphological features obtained on FNAC and later correlated with Histopathological findings. Results: 44 (16.08%) cases were categorised as inflammatory lesion. 208 (75.91%) cases were categorised as functional disorders like nodular goitre, nodular goitre with cystic degeneration. 10 (3.64%) cases were categorised as follicular neoplasm. Most common malignancy was papillary carcinoma with 7 (2.55%) cases. Un common malignancy was medullary carcinoma 1(0.36%) case. Keywords:  FNAC, Kadapa, Medullary carcinoma, Papillary carcinoma

scholarly journals Morphological Spectrum of Lesions Seen in Thyroidectomy Specimens At A Tertiary Care Institute

Esculapio ◽  
2020 ◽  
Vol 16 (03, july 2020-Septmber 2020) ◽  
Author(s):  
Iram Nadeem ◽  
Samra Sameen ◽  
Sahar Iqbal ◽  
Tazeen Anis
Keyword(s):  
Papillary Carcinoma ◽  
Tertiary Care ◽  
Follicular Adenoma ◽  
Follicular Carcinoma ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Cell Adenoma ◽  
Care Institute ◽  
Hyalinizing Trabecular Tumor ◽  
Neoplastic Lesions

Objective: To determine the morphological spectrum of thyroid lesions encountered in thyroidectomy specimens at a tertiary care institute. Methods: It was a retrospective study conducted in Pathology Department, Allama Iqbal Medical College, Lahore. A retrospective manual collection of data was done from record registers, for the years 2012 & 2013. Results: A total of 307 cases were retrieved with age range of 16-70 years. Amongst them, 47 were males and 260 were females. Non neoplastic conditions outnumbered the neoplastic lesions as 229(75%) cases were of colloid goiter. Hashimoto thyroiditis was present in 12(3.9%) specimens and associated hyperplastic changes were seen in 15(4.9%) cases. There were 19(6.2%) cases of papillary carcinoma, 3(0.9%) cases of follicular carcinoma, 3(0.9%) cases of medullary carcinoma, 1(0.3 %) case of insular carcinoma and 2(0.6%) anaplastic carcinoma. Papillary microcarcinoma was seen in 4(1.3 %) cases and medullary microcarcinoma in 1(0.3%) case. Follicular adenoma comprised 29(9.4%) cases and Hurthle cell adenoma 3(0.9%) cases. Study data also showed 1(0.3%) rare case of hyalinizing trabecular tumor. Conclusion: Non neoplastic thyroid diseases are more common as compared to neoplastic lesions. Papillary carcinoma is most common thyroid malignancy encountered in our setting. Key Words: Thyroidectomy, Colloid goiter, papillary carcinoma

scholarly journals Malignant Thyroid Lesions: A Histopathological Perspective

2019 ◽  
pp. 1-10
Author(s):  
Innocent Emmanuel ◽  
Mansur Aliyu Ramalan ◽  
Adam Ochigbo ◽  
Philip Akpa ◽  
Daniel Yakubu ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Female Gender ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Diagnostic Methods ◽  
University Teaching ◽  
Female Ratio ◽  
Thyroid Cancers ◽  
Age Range

Introduction: Thyroid cancer incidence is increasing globally. This increase has been attributed to improvement in diagnostic methods. This study has as its aim the analysis of the pattern of thyroid gland malignancies seen at the Jos University Teaching Hospital, Jos, Nigeria, between January 2008 and December 2018. Methodology: A descriptive retrospective study of consecutive cases of thyroid specimens analyzed at our center was done. Data was obtained from the Histopathology Department Records. The diagnosis of each case was confirmed by reviewing archival slides. Results: There were 70 cases of thyroid carcinomas during the period of the study. The histological types of thyroid cancers seen were: follicular carcinoma, papillary carcinoma, medullary carcinoma and anaplastic carcinoma, respectively accounting for 36(51.4%), 23(32.9%), 4(5.7%) and 7(8.6%) cases. There was only 1 case of follicular carcinoma in 2012, and non between 2013 and 2018. The male to female ratio was 1: 3.1. The mean age of thyroid carcinoma was 42.7 years, with an age range of 13-80 years. Conclusion: The histological pattern of thyroid cancers has changed over the last two decades in our environment with the erstwhile predominant follicular carcinoma receding to near disappearance. The papillary carcinoma histotype is currently overwhelmingly the commonest type diagnosed. The former is relatively commonly seen in the older age group, in a sharp contrast with the later. The female gender remains the most afflicted group.

scholarly journals A PROSPECTIVE STUDY ABOUT THE SURGICAL MANAGEMENT OF THYROID CARCINOMA

2019 ◽  
pp. 1-5
Author(s):  
Anil Kumar Dubey ◽  
Yuvraj Churendra
Keyword(s):  
Thyroid Carcinoma ◽  
Prospective Study ◽  
Total Thyroidectomy ◽  
Papillary Carcinoma ◽  
Age Groups ◽  
Medullary Carcinoma ◽  
Good Prognosis ◽  
Follicular Neoplasm ◽  
Female Ratio ◽  
Prospective Study Design

INTRODUCTION : Thyroid cancer is one of the most common endocrine cancer and has the highest mortality among endocrine neoplasms. In India, its incidence is between 0.8–2 per 1,00,000 population. Early diagnosis and treatment remain the cornerstone of management to decrease the mortality rates. lack of prospective randomized trials, the management of these cancers generates tremendous controversy. study was planned to assess & evaluate the management of various thyroid carcinomas. METHODS: A total of 40 patients were selected which were pathologically / histologically proven cases of Thyroid carcinoma in this Prospective study design in 2.5 years. Detailed Clinical Examination was done & Prior to surgery all the patients went through investigations. Subjects included both the genders , all age groups including pediatric and geriatric age group and all classes of socio economic strata. RESULTS: No of female patients were 30 and male patients 10.Male :female ratio in this study was 1:3.FNAC / Biopsy / Cytology detected papillary carcinoma in 26 patients (65%) ,follicular neoplasm in 11 patients (27.5%) ,2 (5%) patients of anaplastic and one (2.5%) of medullary carcinoma. 86.6% of the patients had a firm gland & hard gland and rest presented with a soft gland on palpation.Total Thyroidectomy with cervical block dissection was performed in 32 (80%) cases .Rest of the 20 % were dealt with Sub total Thyroidectomy with cervical block dissection. CONCLUSION: Most of the cancers present as a slow growing goiter for few months to few years duration.Most of the cancers are of papillary carcinoma type , FNAC detects the majority of the cancers and is an important diagnostic test.Thyroid cancers have a good prognosis as most of the patients present as Stage I disease & most of the patients require total thyroidectomy with or without lymph node dissection followed by radio iodine ablation as treatment.Thyroid cancer,irrespective of the extent of disease,has good prognosis

scholarly journals Clinicopathological Study of Thyroid Swellings with Some Emphasis on Geographical and Community Distribution: A Hospital Based Analysis

2016 ◽  
Vol 24 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Kusum Borsaikia ◽  
Mukul Patar
Keyword(s):  
Papillary Carcinoma ◽  
Low Cost ◽  
Medullary Carcinoma ◽  
Follicular Neoplasm ◽  
Medical College ◽  
North East ◽  
Adenomatous Goiter ◽  
Tribal Communities ◽  
Brahmaputra Valley ◽  
High Prevalence

Introduction: Thyroid swellings/goiter are still prevalent in north east part of India. Apart from its sub-Himalayan location the areas along the river Brahmaputra suffer from flooding every year and there is also frequent changing of river course, thought to be another reason for iodine depletion in soil of this region(3).       Aim: To determine the incidence of thyroid swellings and distribution among different sections of society and geographical areas, and to evaluate the role of FNAC in the diagnosis and management and find out its accuracy by comparing with histopathology.     Materials and methods: In the present study, total 212 patients with thyroid swellings attending department of ENT of a state medical college during the period from January 2013 to December 2015 and undergone FNAC at department of Pathology were taken into consideration.     Results: Out of 212 cases major fraction (52.83%) were hailed from areas along the Brahmaputra river followed by patients (33.96%) from tea gardens and adjacent areas. Patients belonging to tribal communities constituted 45.28%, whereas patients from tea workers section of society formed the second majority (34.9%). Female male ratio of cases was 5:1. Majority of patients were from 21-40 years age group with mean age of 37.2 years.  Cytology results of 212 cases showed colloid goiter 73.58%, adenomatous goiter 8.49%, thyroiditis 9.9%, hurthle cell neoplasm 1.41%, follicular neoplasm 4.24%, papillary carcinoma 1.41%, papillary carcinoma of follicular variant 0.47% and medullary carcinoma in 0.47% cases. Histopathology was possible in 65 cases and compared with FNAC results with accuracy rate of 89.23%.     Conclusion: Frequent flooding and changes of river course may be one of the reasons for high prevalence of thyroid swellings and goiter along the Brahmaputra valley apart from its sub-Himalayan location. Consumption polluted drinking water and goitergenous food stuffs may be another reason of high incidence. FNAC is an easy, rapid, reliable, less invasive, low cost technique for diagnosis of thyroid swellings. 

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