Long-term effects of GH replacement therapy on thyroid function in children with GH deficiency

2019 ◽  
Author(s):  
Ida D'Acunzo ◽  
Federica Anselmi ◽  
Valeria Gaeta ◽  
Flavia Barbieri ◽  
Gian Paolo Ciccarelli ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Thyroid Function ◽  
Gh Deficiency ◽  
Long Term Effects ◽  
Gh Replacement

scholarly journals Long-term effects of growth hormone (GH) replacement therapy on hematopoiesis in a large cohort of children with GH deficiency

Endocrine ◽  
2015 ◽  
Vol 53 (1) ◽  
pp. 192-198 ◽  
Author(s):  
Andrea Esposito ◽  
Donatella Capalbo ◽  
Lucia De Martino ◽  
Martina Rezzuto ◽  
Raffaella Di Mase ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Replacement Therapy ◽  
Gh Deficiency ◽  
Large Cohort ◽  
Long Term Effects ◽  
Gh Replacement

LONG-TERM EFFECTS OF ADRENALECTOMY AND GONADECTOMY ON THYROID FUNCTION IN THE RAT

1965 ◽  
Vol 48 (4) ◽  
pp. 556-560 ◽  
Author(s):  
Jerome A. Grunt ◽  
Russell D. Cunningham
Keyword(s):  
Replacement Therapy ◽  
Thyroid Function ◽  
Hormonal Replacement Therapy ◽  
Female Rats ◽  
Follicular Epithelium ◽  
Long Term Effects ◽  
Male And Female ◽  
Hormonal Replacement ◽  
Male And Female Rats

ABSTRACT Thyroid function has been evaluated in male and female rats which had been either sham operated, gonadectomized, adrenalectomized, or adrenalectomized and gonadectomized on day 25, and killed at 180 days of age. No hormonal replacement therapy was utilized. Animals without adrenals showed increased thyroid weights, increased cell heights of follicular epithelium and decreased resin binding of 131I labeled triiodothyronine without significant changes in BEI. Possible mechanisms for these changes in thyroid function are discussed.

The benefit of long-term growth hormone (GH) replacement therapy in hypopituitary adults with GH deficiency: Results of the German KIMS database

2011 ◽  
Vol 21 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Christin Spielhagen ◽  
Christian Schwahn ◽  
Kristin Möller ◽  
Nele Friedrich ◽  
Thomas Kohlmann ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Replacement Therapy ◽  
Gh Deficiency ◽  
Gh Replacement

scholarly journals Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency

2012 ◽  
Vol 97 (9) ◽  
pp. 3185-3195 ◽  
Author(s):  
Helena Filipsson Nyström ◽  
Edna J. L. Barbosa ◽  
Anna G. Nilsson ◽  
Lise-Lott Norrman ◽  
Oskar Ragnarsson ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Crossover Trial ◽  
Gh Deficiency ◽  
Gh Replacement ◽  
Adult Gh Deficiency

scholarly journals Effect of long-term GH replacement therapy on cardiovascular outcomes in isolated GH deficiency compared with multiple pituitary hormone deficiencies: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults

2014 ◽  
Vol 171 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Christa C van Bunderen ◽  
Carline J van den Dries ◽  
Martijn W Heymans ◽  
Anton A M Franken ◽  
Hans P F Koppeschaar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Replacement Therapy ◽  
Clinical Presentation ◽  
Gh Deficiency ◽  
National Registry ◽  
Pituitary Hormone ◽  
Gh Treatment ◽  
Gh Replacement

ObjectiveIsolated GH deficiency (IGHD) could provide a model to investigate the influence of GH deficiency per se and the effect of GH replacement therapy without the influence from other pituitary hormone deficiencies or their treatment. The aim of this study is to address the questions about differences between IGHD and multiple pituitary hormone deficiencies (MPHDs) in clinical presentation and in responsiveness to GH treatment.DesignA nationwide surveillance study was carried out to describe the difference in the clinical presentation and responsiveness to GH treatment of patients with IGHD and MPHDs.MethodsThe Dutch National Registry of GH Treatment in Adults was founded in 1998 to gain more insight into long-term efficacy and safety of GH therapy. Out of 2891 enrolled patients, 266 patients with IGHD at the start of GH treatment were identified and compared with 310 patients with MPHDs. Cardiovascular indices will be investigated at baseline and during long-term follow-up, including body composition, lipid profile, glucose metabolism, blood pressure, and morbidity.ResultsPatients with IGHD and MPHDs were demonstrated to be different entities at clinical presentation. Metabolically, patients with MPHDs had a larger waist circumference, lower HDL cholesterol level, and higher triglyceride level. The effect of GH treatment was comparable between patient groups. GH seems to protect against rising lipid levels and blood pressure, even after excluding patients using corresponding concomitant medication. The risk for cardiovascular disease or diabetes mellitus during follow-up was not different between patients with IGHD and MPHDs.ConclusionsPatients with IGHD had a less impaired metabolic profile than patients with MPHDs at baseline. Influence of other pituitary hormone replacement therapies on the effect of GH treatment is not demonstrated.

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