scholarly journals Age-dependent sex differences in calcium and phosphate homeostasis

2021 ◽  
Author(s):  
W N H Koek ◽  
N Campos-Obando ◽  
B C J van der Eerden ◽  
Y B De Rijke ◽  
Ma Ikram ◽  
...  
Keyword(s):  
Sex Differences ◽  
Serum Calcium ◽  
Age Groups ◽  
Serum Phosphate ◽  
Age Group ◽  
Phosphate Homeostasis ◽  
Younger Age ◽  
Age Dependent ◽  
Underlying Mechanisms ◽  
Group 1

Background: Sex differences in calcium and phosphate have been observed. We aimed to assess a relation with age. Methods: We used laboratory values of serum calcium, phosphate and albumin from three different samples (years 2005, 2010 and 2014) using the hospital information system of Erasmus MC, Rotterdam. The samples were divided into 3 age groups: 1-17, 18-44 and ≥45 years. Sex differences in calcium and phosphate were analyzed using ANCOVA, adjusting for age and serum albumin. Furthermore, sex by age interactions were determined and we analyzed differences between age groups stratified by sex Results: In all 3 samples there was a significant sex*age interaction for serum calcium and phosphate, whose levels were significantly higher in women compared to men above 45 years. No sex differences in the younger age groups were found. In men, serum calcium and phosphate levels were highest in the youngest age group compared to age groups 18-44 and ≥45 years. In women, serum calcium levels were also significantly higher in the age group 1-17 and the age group ≥45 years compared to the 18-44 years age group. In women, serum phosphate was different between the three different age groups with highest level in the group 1-17 years and lowest in the group 18-44 years. Conclusion: There are age dependent sex differences in serum calcium and phosphate. Furthermore, we found differences in serum calcium and phosphate between different age groups. Underlying mechanisms for these age- and sex differences are not yet fully elucidated.

scholarly journals Tower Running—Participation, Performance Trends, and Sex Difference

2020 ◽  
Vol 17 (6) ◽  
pp. 1902 ◽  
Author(s):  
Daniel Stark ◽  
Stefania Di Gangi ◽  
Caio Victor Sousa ◽  
Pantelis Nikolaidis ◽  
Beat Knechtle
Keyword(s):  
Sex Differences ◽  
Statistical Model ◽  
Sex Difference ◽  
Random Effects ◽  
Age Groups ◽  
Repeated Measurements ◽  
Stair Climbing ◽  
Age Group ◽  
Performance Trends ◽  
The Difference

Though there are exhaustive data about participation, performance trends, and sex differences in performance in different running disciplines and races, no study has analyzed these trends in stair climbing and tower running. The aim of the present study was therefore to investigate these trends in tower running. The data, consisting of 28,203 observations from 24,007 climbers between 2014 and 2019, were analyzed. The effects of sex and age, together with the tower characteristics (i.e., stairs and floors), were examined through a multivariable statistical model with random effects on intercept, at climber’s level, accounting for repeated measurements. Men were faster than women in each age group (p < 0.001 for ages ≤69 years, p = 0.003 for ages > 69 years), and the difference in performance stayed around 0.20 km/h, with a minimum of 0.17 at the oldest age. However, women were able to outperform men in specific situations: (i) in smaller buildings (<600 stairs), for ages between 30 and 59 years and >69 years; (ii) in higher buildings (>2200 stairs), for age groups <20 years and 60–69 years; and (iii) in buildings with 1600–2200 stairs, for ages >69 years. In summary, men were faster than women in this specific running discipline; however, women were able to outperform men in very specific situations (i.e., specific age groups and specific numbers of stairs).

scholarly journals Comparison of Prevalence of Periodontitis with Different Indices in Population of District Ghaziabad

2016 ◽  
Vol 04 (01) ◽  
pp. 023-030
Author(s):  
Vimal Kumar ◽  
Pallak Arora ◽  
Manish Khatri ◽  
Shivani Sharma ◽  
Sumit Malhotra ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Total Population ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Sample Population ◽  
Age Group ◽  
Cross Sectional ◽  
Multi Stage ◽  
Younger Age ◽  
Study Population

Abstract Objective: To estimate the prevalence of periodontal disease with different indices. Methods & materials: The study population consisted of multistage stratified random sample of 1300 subjects from total population of district Ghaziabad. A cross-sectional study was conducted with multi stage stratified random sampling techniques to select the sample population. The subjects were divided into different age groups and the periodontal assessment was made on the basis of CPITN index and ESI Index. Results: The CPITN has shown to estimate incorrect periodontal disease prevalence because of its underestimation of the disease severity. A huge difference was noticed in the prevalence rate of periodontitis when subjects were examined with ESI index. Conclusion Periodontal disease was found to be highly prevalent in the study population and severity of disease increased with age. More number of subjects in younger age group were found to be healthy.

scholarly journals Cortisol and Phosphate Homeostasis: Cushing’s Syndrome Is Associated With Reversible Hypophosphatemia

2021 ◽  
Vol 12 ◽  
Author(s):  
Ariadne Bosman ◽  
Annewieke W. van den Beld ◽  
Richard A. Feelders ◽  
M. Carola Zillikens
Keyword(s):  
Linear Regression ◽  
Cushing’S Syndrome ◽  
Urinary Free Cortisol ◽  
Population Based ◽  
Cushing's Syndrome ◽  
Serum Phosphate ◽  
Rotterdam Study ◽  
Phosphate Homeostasis ◽  
Free Cortisol ◽  
Underlying Mechanisms

ObjectivesThe influence of hypercortisolism on phosphate homeostasis is relatively unknown. A few previous studies have reported on patients with Cushing’s syndrome (CS) with hypophosphatemia in whom serum phosphate normalized after initiation of treatment for CS. We aimed to investigate the prevalence of hypophosphatemia in CS, the association between the degree of hypercortisolism and serum phosphate and the change in serum phosphate after remission of CS. We compared the prevalence of hypophosphatemia in CS with the prevalence in the population-based Rotterdam Study (RS).MethodsPatients diagnosed with CS and treated at the Department of Endocrinology of Erasmus MC in the period of 2002-2020 were included and data was collected on age at diagnosis, sex, serum phosphate, calcium and potassium levels, kidney function and BMI. Using multivariate linear regression, we analyzed the association between 24h urinary free cortisol excretion (UFC) and serum phosphate. Changes in serum phosphate and covariates were tested with a repeated measurement ANOVA, using mean levels of laboratory values for the periods before remission, and 0-14 days and 15-180 days after remission.ResultsHypophosphatemia before treatment was present in 16% of the 99 CS patients with data on serum phosphate, 24h UFC and covariates. In comparison, the prevalence of hypophosphatemia in RS was 2.0-4.2%. Linear regression showed a negative association between the level of UFC and serum phosphate at diagnosis, which remained significant after adjusting for covariates [β -0.002 (95%CI -0.004; -0.0004), p=0.021]. A subset of 24 patients had additional phosphate measurements at 0-14 days and 15-180 days after remission. In this subgroup, serum phosphate significantly increased from 1.03 ± 0.17 mmol/L prior to remission to 1.22 ± 0.25 mmol/L 15-180 days after remission (p = 0.008). BMI decreased after remission [-1.1 kg/m2, (95%CI -2.09 to -0.07), p=0.037]. Other covariates did not show an equivalent change over time.ConclusionIn this retrospective study, we found that 16% of patients with CS had hypophosphatemia. Moreover, serum phosphate was related to the level of cortisoluria and increased after remission of CS. Potential underlying mechanisms related to urinary phosphate excretion and possibly involving FGF23, BMI and parathyroid hormone levels should be further explored.

scholarly journals Predictive Value of Technical Throwing Skills on Nomination Status in Youth and Long-Term Career Attainment in Handball

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Till Koopmann ◽  
Franziska Lath ◽  
Dirk Büsch ◽  
Jörg Schorer
Keyword(s):  
Logistic Regression ◽  
National Level ◽  
Age Groups ◽  
Age Group ◽  
Regression Analyses ◽  
Chi Square ◽  
Career Attainment ◽  
Future Performance ◽  
Younger Age

Abstract Background Research on talent in sports aims to identify predictors of future performance. This study retrospectively investigated 1) relationships between young handball field players’ technical throwing skills and (a) their potential nomination to youth national teams and (b) their long-term career attainment 10 years later, and 2) associations between nomination status and career attainment. Results Results from retrospectively predicting nomination status and career attainment using logistic regression analyses show that technical throwing skills were partly able to explain players’ nomination status (Nagelkerke R2: females 9.2%, males 13.1%) and career attainment (Nagelkerke R2: 9.8% for female players). Here, variables throwing velocity and time on exercise showed statistically significant effects. In addition, nomination status and career attainment were shown to be associated using chi-square tests (w of .37 and .23 for female and male players, respectively) and nomination status as a predictor increased the prediction of career attainment remarkably (Nagelkerke R2: females 20.3%, males 12.7%). Conclusions Given these results, basic technical throwing skills may serve rather as a prerequisite in this age group on national level, emphasizing its importance already on lower levels and in younger age groups. Furthermore, advantages from entering the national TID system early especially for females are discussed.

scholarly journals Age and sex variation in visceral adipose tissue

2019 ◽  
Vol 6 (1) ◽  
pp. 101
Author(s):  
Pallavi Panchu ◽  
Biju Bahuleyan ◽  
Rose Babu ◽  
Vineetha Vijayan
Keyword(s):  
Adipose Tissue ◽  
Visceral Fat ◽  
Metabolic Disorders ◽  
Age Groups ◽  
Fat Distribution ◽  
Age Group ◽  
Cross Sectional ◽  
Younger Age ◽  
The Difference ◽  
Gender Pattern

Background: Adipose tissue mainly visceral fat is said to be harmful and acts as a harbinger of metabolic disorders. A changing trend is seen in the recent decades with decreasing incidence of metabolic disorders in men even though visceral fat is said to be higher in them. Sex hormones may influence the deposition pattern of adipose tissue. The aim of this study was to observe effects of age on visceral fat and to know if the difference in gender pattern of fat distribution is maintained throughout life or disappears after menopause.Methods: This cross-sectional observational study was conducted in Thrissur on 385 apparently healthy subjects using Omron body composition analyser. Data was analysed using SPSS 20.0 version. The tests employed were NOVA, independent samples t-test.Results: In each age group, men had significantly higher visceral fat than females. As age increased, visceral fat increased significantly in both genders. In each group, except for younger age groups, VF levels were equal in men and women.Conclusions: Visceral fat is higher in men and this difference is seen in all age groups. As age increases, visceral fat levels also increased in men and women. The distribution of visceral fat is such that a greater number of men have high to very high levels at a younger age group, a feature observed in women only in the peri and post-menopausal age. Adoption of an active lifestyle coupled with healthy diet should protect against onset of metabolic disorders.

scholarly journals Monitoring HIV Epidemic in Pregnant Women: Are the Current Measures Enough?

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Purva Sarkate ◽  
Supriya Paranjpe ◽  
Nayana Ingole ◽  
Preeti Mehta
Keyword(s):  
Pregnant Women ◽  
Age Groups ◽  
Age Group ◽  
Child Transmission ◽  
Hiv Epidemic ◽  
Opt Out ◽  
Younger Age ◽  
Heterogeneous Nature ◽  
Program Data ◽  
Local Levels

Introduction. Burden of HIV in pregnant women follows overall epidemic in India. Hence, it is imperative that prevalence calculations in this group be accurate. The present study was carried out to determine prevalence of HIV in pregnant women attending our hospital, to determine trend of HIV infection and to compare our results with reported prevalence. Methods. All pregnant women are routinely counselled for HIV testing using opt-out strategy. Year-wise positivity and trend were determined in these patients over a period of five years. The positivity in different age groups was determined. Results. 31,609 women were tested of which 279 (0.88%) were positive. Positivity showed a declining trend over study period and significant quadratic trend (biphasic, P<0.05) was observed. The positivity in older age group ≥35 years (1.64%) was significantly more than younger age groups (0.76% in 15–24-year and 0.94% in 25–34-year age group) (P=0.0052). Conclusion. A significant decline in HIV positivity was seen over the study period. Taking into account heterogeneous nature of HIV epidemic even within the same district, analysis at local levels especially using the prevention of parent to child transmission of HIV program data is critical for HIV programming and resource allocation.

scholarly journals Sex differences in non-communicable disease prevalence in China: a cross-sectional analysis of the China Health and Retirement Longitudinal Study in 2011

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e017450 ◽  
Author(s):  
Yan Liu ◽  
Guofeng Liu ◽  
Hongjiang Wu ◽  
Weiyan Jian ◽  
Sarah H Wild ◽  
...  
Keyword(s):  
Sex Differences ◽  
Heart Disease ◽  
Longitudinal Study ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Communicable Disease ◽  
Age Groups ◽  
Sociodemographic Factors ◽  
Age Group ◽  
Cross Sectional

ObjectivesTo describe the sex differences in the prevalence of non-communicable diseases (NCDs) in adults aged 45 years or older in China.DesignCross-sectional study.SettingNationally representative sample of the Chinese population 2011.Participants8401 men and 8928 women over 45 years of age who participated in the first wave of the China Health and Retirement Longitudinal Study (CHARLS).Outcome measuresSelf-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis. Sex differences in NCDs were described using logistic regression to generate odds ratios (OR) with adjustment for sociodemographic factors and health-related behaviours. All analyses were stratified by age group for 45–64-year-old and ≥65-year-old participants.ResultsIn both age groups, men reported better overall health than women. The crude prevalence of heart disease, cancer and arthritis was higher while that of stroke and chronic lung disease was lower in women than in men. After adjustment, ORs (95% CI) for the 45–64 and ≥65 year age groups were 0.70 (0.58 to 0.84) and 0.66 (0.54 to 0.80), respectively, for arthritis for men compared with women. In contrast, ORs were 1.66 (1.09 to 2.52) and 2.12 (1.36 to 3.30) for stroke and 1.51 (1.21 to 1.89) and 1.43 (1.09 to 1.88) for chronic lung disease for men compared with women. ORs for heart disease (0.65 (0.52 to 0.80)) were lower in men than in women only in the 45–64 year age group.ConclusionsOdds of arthritis were lower while those of stroke and chronic lung disease were higher in men than in women in both age groups. However, odds of heart disease were lower in men than in women, but only in the group of individuals aged 45–64 years.

Dietary Fluoride Intake of Infants

PEDIATRICS ◽  
1975 ◽  
Vol 55 (4) ◽  
pp. 517-522
Author(s):  
Emilie Wiatrowski ◽  
Louis Kramer ◽  
Dace Osis ◽  
Herta Spencer
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Age Groups ◽  
Fluoride Content ◽  
Age Group ◽  
Infant Diet ◽  
Food Items ◽  
Fluoride Intake ◽  
Group 1

The fluoride content of various commercially available food items used in the preparation of the infant diet for the age groups from birth to 6 months has been analyzed and the total daily fluoride intake has been calculated on the basis of these data. The dietary fluoride intake totaled 0.32 mg/day for infants in the age group 1 to 4 weeks, increased in the subsequent months due to increasing food intake, and totaled 1.23 mg for infants 4 to 6 months of age. These fluoride intakes expressed per kilogram of body weight ranged from 0.07 mg/kg in the newborn to 0.16 mg/kg in the 6-month-old infant.

Ontogeny of neonatal pulmonary vascular pressure-flow relationships

1992 ◽  
Vol 262 (3) ◽  
pp. H684-H690 ◽  
Author(s):  
M. L. Tod ◽  
K. Yoshimura ◽  
L. J. Rubin
Keyword(s):  
Blood Flow ◽  
Pressor Response ◽  
Age Groups ◽  
Vascular Occlusion ◽  
Pressure Gradients ◽  
Age Group ◽  
Middle Region ◽  
Younger Age ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Arteries And Veins

Previously we reported that pulmonary vascular pressure gradients determined by vascular occlusion varied as a function of neonatal age. The purpose of this study was to evaluate the effect of blood flow on pressure gradients during normoxia (inspired O2 28%) and hypoxia (inspired O2 4.2%) in isolated, indomethacin-treated lungs obtained from lambs at less than 1, 2-4, 12-14, and 30-32 days of age (n = 6 at each age). The total pulmonary pressure gradient was partitioned into pressure gradients across relatively indistensible arteries and veins and relatively compliant vessels in the middle region (delta Pm) by inflow and outflow occlusions at flows of 25, 50, 75, and 100 ml.kg-1.min-1. During normoxia, lungs from lambs less than 1 day of age had significantly greater pressures at each flow than lungs from older lambs, due primarily to a significantly greater delta Pm in this age group. During hypoxia, the greatest vasoconstriction occurred in the youngest group, also due mostly to an increased delta Pm. This enhanced response to hypoxia in the younger age groups was due to inhibition of prostaglandin synthesis; without indomethacin treatment, the older age groups had a greater hypoxic pressor response than the younger groups. The arterial vascular resistance at all ages was relatively constant as a function of blood flow during both normoxia and hypoxia, whereas the total and middle vascular resistances generally decreased as a function of flow. The venous resistance initially decreased and then was constant. These results suggest that the neonatal pulmonary circulation h as a fixed arterial resistance, a slightly distensible venous region at low flows, and a more distensible middle region.

scholarly journals Interaction Between Age and Change in Velocity During a Baseball Training Program

2020 ◽  
Vol 8 (6) ◽  
pp. 232596712092793
Author(s):  
Christopher Antonacci ◽  
Thomas R. Atlee ◽  
Peter N. Chalmers ◽  
Christopher Hadley ◽  
Meghan E. Bishop ◽  
...  
Keyword(s):  
Training Program ◽  
Age Groups ◽  
Maximum Velocity ◽  
Age Group ◽  
Significant Difference ◽  
Group 3 ◽  
Baseball Pitchers ◽  
Group 2 ◽  
The Relationship ◽  
Group 1

Background: Pitching velocity is one of the most important metrics used to evaluate a baseball pitcher’s effectiveness. The relationship between age and pitching velocity after a lighter ball baseball training program has not been determined. Purpose/Hypothesis: The purpose of this study was to examine the relationship between age and pitching velocity after a lighter ball baseball training program. We hypothesized that pitching velocity would significantly increase in all adolescent age groups after a lighter baseball training program, without a significant difference in magnitude of increase based on age. Study Design: Cohort study; Level of evidence, 2. Methods: Baseball pitchers aged 10 to 17 years who completed a 15-week training program focused on pitching mechanics and velocity improvement were included in this study. Pitchers were split into 3 groups based on age (group 1, 10-12 years; group 2, 13-14 years; group 3, 15-17 years), and each group trained independently. Pitch velocity was assessed at 4 time points (sessions 3, 10, 17, and 25). Mean, maximum, and mean change in pitch velocity between sessions were compared by age group. Results: A total of 32 male baseball pitchers were included in the analysis. Mean/maximum velocity increased in all 3 age groups: 3.4/4.8 mph in group 1, 5.3/5.5 mph in group 2, and 5.3/5.2 mph in group 3. While mean percentage change in pitch velocity increased in all 3 age groups (group 1, 6.5%; group 2, 8.3%; group 3, 7.6%), the magnitude of change was not significantly different among age groups. Program session number had a significant effect on mean and maximum velocity, with higher mean and maximum velocity seen at later sessions in the training program ( P = .018). There was no interaction between age and program session within either mean or maximum velocity ( P = .316 and .572, respectively). Conclusion: Age had no significant effect on the magnitude of increase in maximum or mean baseball pitch velocity during a velocity and mechanics training program in adolescent males.

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